Genetic ALK/EML4 - Tumors DNA Test


Genetic ALK/EML4 - Tumors DNA Test

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A recurrent gene fusion between EML4 and ALK of non-small cell lung cancers and NKX2-1 high-level amplifications of adenocarcinomas of the lung were independently reported recently.

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To assess for rearrangements of both the EML4 and ALK loci, two unique break-apart FISH assays were designed. For each gene, two bacterial artificial chromosome FISH probes were created to hybridize with the neighboring centromeric and telomeric regions of each gene.
For EML4, the centromeric BAC clone was biotin-14-deoxycytidine triphosphate (dCTP) labeled RP11-368J11 and the telomeric BAC clone was digoxigenin-dUTP-labeled RP11-142M12.