Genetic CLL PANEL (Cytogenetics + FISH [del(6q), del(11q), trisomy 12, del(13q), del(17p)]) DNA Test


Genetic CLL PANEL (Cytogenetics + FISH [del(6q), del(11q), trisomy 12, del(13q), del(17p)]) DNA Test

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Cost 21,000/- Rs

The analysis of chromosomal abnormalities in chronic lymphocytic leukemia is important at diagnosis, since it allows the identification of a malignant clone as well as helping in the differentiation of other lymphoproliferative disorders.

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In order to permit the detection of additional abnormalities; in the therapeutic decision, since the presence of del(17p) means resistance to treatment; in treatment monitoring as it allows the detection of residual disease or the diagnosis of transformation (Richter’s transformation). Cytogenetics offers prognostic information and a better understanding of the disease. The analysis can be made by conventional G banding karyotyping, which detects around one third of abnormal cases or by FISH, which increases the rate of abnormality detection to 82%. FISH together with other prognostic criteria (mutation status, ZAP-70, etc) has allowed a better prognostication. The most frequent abnormalities are: trisomy 12 (+12), with a median survival of 9 years; translocation or deletion of 13q (t/del(13q)) with favorable prognosis and median survival of 11 years; deletion or translocation of 11q22-23, with 6.6 years of median survival; deletion of short arm of chromosome 17, del(17p), with median survival of 2.5 years; and deletion of 6q, translocation of 14q, giving a total of around 60% of the total abnormalities. Considering the importance of cytogenetics and prognostic information, every chronic lymphocytic leukemia patient should undergo FISH and karyotype evaluations.
Reporting Time : 3 Days (From the day sample reaches our Lab)
Whole blood: Send in EDTA Tubes (Purple Top Vacutainer)
Blood Spots FTA Cards
Check Sample Buccal Swabs

At DNA Labs India, we are dedicated to quality DNA testing. We know that you need accurate, reliable results for such an important test, and we are committed to providing you with high quality DNA testing services. By choosing DNA Labs India, you will receive the highest quality, most conclusive results in the industry.

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