Genetic Del(13q) (MM, CLL) DNA Test


Genetic Del(13q) (MM, CLL) DNA Test

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Del(13q) in MM is rarely observed as a sole anomaly detected both in hyperdiploid and hypodiploid karyotypes, but with a higher incidence in hypodiploi forms consequently, according to some authors, the prognostic value of del(13q) should have to be related to the ploidy.

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Multiple myeloma (MM) is a monoclonal B-cell malignancy, which originates theoretically in lymph node germinal centers but locates and expands in bone marrow. It represents 10% of all the hematopoietic cancers, with a great variability in clinical presentation, response to therapy and survival duration. In more than 1/3 of cases, MM can be preceded by a phase of monoclonal gammopathy of uncertain significance.
Del(13q) is clearly underscored by karyotyping because a number of deletions are submicroscopic or only detected in interphase nuclei.