Genetic FGFR3/IgH (MM) DNA Test


Genetic FGFR3/IgH (MM) DNA Test

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Cost 6,000/- Rs

The IGH/FGFR3 translocation probe is designed to detect the translocation between theFGFR3 gene located on 4p16 and the IGH gene located on 14q32 using fluorescence in situ hybridization

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Rearrangement of the FGFR3 and IGH genes is desginated as t(4;14) and it has been observed in multiple myeloma patients. Detection of the t(4;14) translocation is clinically relevant because it confers an aggressive phenotype with a poor prognosis and a rapid relapse after high-dose chemotherapy.