Genetic MM PANEL (Cytogenetics + FISH [del(11q), del(13q), IgH, del(17p)]) DNA Test


Genetic MM PANEL (Cytogenetics + FISH [del(11q), del(13q), IgH, del(17p)]) DNA Test

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Cost 21,000/- Rs

The importance of interphase fluorescence in situ hybridization DNA analysis as a predictive tool for survival in patients with chronic lymphocytic leukemia is well established.

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Importantly, in patients with del(13q) CLL, an unmutated immunoglobulin heavy-chain variable (IGHV) region mutational sequence predicts for rapid Rai stage disease progression,treatment initiation, and poor overall survival. In this article, the influence of IGHV mutational status on OS in patients with CLL harboring the poor prognostic FISH findings of del(11q) and del(17p) is analyzed.This report includes all patients who had IGHV sequence homology analysis performed and also had del(11q) or del (17p) detected by FISH evaluation during the clinical course of the disease. At our center, standard laboratory practice for patients with CLL is to perform interphase FISH DNA analysis and IGHV mutational status analysis however all evaluations are at physician discretion.