Genetic PML/RARA (AML - M3 [APML]) DNA Test


Genetic PML/RARA (AML - M3 [APML]) DNA Test

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Acute promyelocytic leukemia is a subtype of acute myeloid leukemia with distinct clinical and histopathologic features. Historically one of the most lethal forms of acute myeloid leukemia, APL leads to disseminated intravascular coagulation.

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The retinoic acid receptor alpha (RARA) gene on chromosome 17 with the PML gene on chromosome 15. A short or a long transcript isoform is produced, depending on the PML breakpoint; the short isoform has been linked to poor outcome, but this association remains controversial. Detection of the PML/RARA translocation is diagnostic for APL, although the diagnosis can also be based on morphology. The presence of this translocation is necessary for response to all-trans-retinoic acid and arsenic trioxide. Thus, the PML/RARA assay is useful for diagnosis and predicting treatment response. It is also helpful for monitoring therapeutic response and MRD and for detecting early relapse.