Genetic X & Y (Sex mismatch bone marrow transplant) DNA Test


Genetic X & Y (Sex mismatch bone marrow transplant) DNA Test

19867 reviews
5.00 out of 5

Cost 6,000/- Rs

A male with pre-B-cell acute lymphoblastic leukemia with cryptic BCR/ABL rearrangement underwent sex-mismatched allogeneic bone marrow transplantation.

Call: (079) 30925079
Y-chromosome-specific quantitative polymerase chain reaction and sex chromosome-specific interphase fluorescence in situ hybridization showed complete donor chimerism. Analysis of autosomal short tandem repeats BCR/ABL i-FISH test, and X-STR haplotype indicated relapse. Metaphase FISH and combined BCR/ABL and sex chromosome-specific i-FISH patterns revealed loss of the Y-chromosome and duplication of the X-chromosome in the host cells. Sex chromosome changes after allo-BMT can cause significant difficulties in chimerism analysis.