Acetylcholinesterase Amniotic Fluid Test
Short Name: AChE Amniotic Fluid Test
Also known as: Amniotic Fluid Acetylcholinesterase Test, AChE Test for Neural Tube Defects
Acetylcholinesterase Amniotic Fluid Test test available at DNA Labs India for ₹13,000. Uses Gel Electrophoresis on Amniotic Fluid samples. Results in Results are typically available within 2-3 weeks after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The primary purpose of this test is to screen for and diagnose neural tube defects and chromosomal abnormalities like Down syndrome in the fetus. By measuring acetylcholinesterase levels in the amniotic fluid, healthcare providers can assess the risk of these conditions, especially in high-risk pregnancies. This enables early intervention, genetic counseling, and informed parental decision-making.
- Test Code
- 52
- Price
- ₹13,000
- Sample Type
- Amniotic Fluid
- Result Time
- Results are typically available within 2-3 weeks after sample collection.
- Fasting Required
- No
- Method
- Gel Electrophoresis
Sample Collection
Patient should be informed about the procedure, risks, and benefits. A duly filled Test Send Out Consent Form (Form 35) is mandatory. Fasting is not required, but hydration and rest are recommended prior to the procedure.
Method: Amniocentesis
Laboratory Analysis
The procedure is performed under ultrasound guidance. A thin needle is inserted through the abdomen into the amniotic sac to withdraw approximately 3 ml of amniotic fluid. The process takes about 15-30 minutes and may cause mild discomfort.
Report Delivery
Patients should rest for a short period post-procedure. Monitor for any signs of complications such as cramping, bleeding, or leakage of amniotic fluid. Avoid strenuous activities for 24 hours.
Timeline: Results are typically available within 2-3 weeks after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of this test is to screen for and diagnose neural tube defects and chromosomal abnormalities like Down syndrome in the fetus. By measuring acetylcholinesterase levels in the amniotic fluid, healthcare providers can assess the risk of these conditions, especially in high-risk pregnancies. This enables early intervention, genetic counseling, and informed parental decision-making.
How to Prepare
- Sample should be drawn between 13-24 weeks gestation
- Indicate gestational age, collection date, and clinical indications on the Test Request Form
- Include AFP and MoM results if available
- Duly filled Test Send Out Consent Form (Form 35) is mandatory
- Avoid blood contamination during collection
- Ship the sample refrigerated or frozen in a sterile screw capped vial
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"This test is essential for early detection of neural tube defects in high-risk pregnancies, enabling timely medical intervention and informed decision-making."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Blood-contaminated sample
- Sample collected outside 13-24 weeks gestation
- Insufficient sample volume (<1 ml)
- Missing or incomplete consent form
Understanding Your Results
Consult your doctor immediately if you experience severe abdominal pain, fever, heavy bleeding, or leakage of fluid from the vagina after the procedure. Also, seek medical advice for interpretation of test results and next steps.
Limitations
- ⚠Not a standalone diagnostic tool; may require confirmatory tests such as ultrasound or genetic counseling
- ⚠Cannot detect all birth defects or genetic disorders
- ⚠Results may be inconclusive in some cases, necessitating repeat testing
Risks & Considerations
- ●Risk of miscarriage (approximately 0.1-0.3%)
- ●Infection at the needle insertion site
- ●Leakage of amniotic fluid
- ●Mild cramping or discomfort
Interfering Factors
- ●Blood contamination of the amniotic fluid sample
- ●Improper sample storage or handling
- ●Timing of collection outside the recommended gestational age (13-24 weeks)
Compare With Similar Tests
| Test | Acetylcholinesterase Amniotic Fluid Test | Alpha-fetoprotein (AFP) Test | Ultrasound Scan | Chorionic Villus Sampling (CVS) | Non-invasive Prenatal Testing (NIPT) |
|---|---|---|---|---|---|
| Comparison | Acetylcholinesterase Amniotic Fluid Test | Screening test for neural tube defects; less specific than AChE test | Imaging technique to visualize fetal anatomy; can detect structural defects but not enzyme levels | Genetic test performed earlier in pregnancy; carries higher risk than amniocentesis | Blood test for chromosomal abnormalities; no risk of miscarriage but may not detect neural tube defects |
Frequently Asked Questions
What is the Acetylcholinesterase Amniotic Fluid Test?
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What are the risks of amniocentesis?
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Can the test detect all birth defects?
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Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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