ALDH2 Gene Acute Alcohol sensitivity NGS Genetic Test
Short Name: ALDH2 Gene Test
Also known as: ALDH2 Mutation Test, Alcohol Sensitivity Genetic Test, Aldehyde Dehydrogenase 2 Gene Test
ALDH2 Gene Acute Alcohol sensitivity NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood samples. Results in Results are typically available within 3 to 4 weeks after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of this test is to detect genetic mutations in the ALDH2 gene that cause acute alcohol sensitivity, enabling diagnosis, risk assessment, and informed decision-making for individuals and healthcare providers.
- Test Code
- 1867
- Price
- ₹20,000
- Sample Type
- Blood
- Result Time
- Results are typically available within 3 to 4 weeks after sample collection.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No specific preparation required. Ensure proper identification and informed consent. Avoid alcohol consumption 24 hours before sample collection if advised by a physician.
Method: Venipuncture
Laboratory Analysis
A blood sample will be drawn by a trained phlebotomist using a sterile needle and syringe. The process typically takes 5-10 minutes.
Report Delivery
Apply pressure to the puncture site to prevent bruising. Resume normal activities. Keep the area clean and dry.
Timeline: Results are typically available within 3 to 4 weeks after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to detect genetic mutations in the ALDH2 gene that cause acute alcohol sensitivity, enabling diagnosis, risk assessment, and informed decision-making for individuals and healthcare providers.
How to Prepare
- Verify patient identity and consent
- Use aseptic technique to clean the puncture site
- Collect blood in an EDTA tube and mix gently
- Label the sample correctly with patient details
- Store at ambient temperature and transport to the lab within 24 hours
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing for ALDH2 mutations is crucial for identifying individuals at risk of alcohol-related complications. Early detection can guide lifestyle modifications and prevent adverse reactions."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted samples
- Insufficient sample volume
- Improperly labeled or unlabeled samples
- Samples collected in incorrect containers
Understanding Your Results
Wild-type (Normal)
No pathogenic variants detected; normal alcohol metabolism expected
Heterozygous for ALDH2*2
One mutated copy; partial enzyme deficiency, may experience mild to moderate symptoms
Homozygous for ALDH2*2
Two mutated copies; severe enzyme deficiency, high risk of acute alcohol sensitivity
Variant of Uncertain Significance (VUS)
Genetic variant found but clinical significance unknown; further testing or counseling recommended
Consult a healthcare provider if you experience symptoms like facial flushing, nausea, or rapid heartbeat after alcohol consumption, or if you have a family history of alcohol sensitivity. After receiving test results, genetic counseling is advised to understand implications and management options.
Limitations
- ⚠This test does not detect all possible ALDH2 variants or other genes involved in alcohol metabolism
- ⚠Results may not predict the severity of symptoms due to environmental and lifestyle factors
- ⚠Limited to genetic factors; does not account for non-genetic causes of alcohol sensitivity
- ⚠Interpretation requires genetic counseling for accurate clinical context
Risks & Considerations
- ●Minor bruising or discomfort at the blood draw site
- ●Very rare risk of infection or bleeding
- ●Emotional impact of genetic results; counseling recommended
Interfering Factors
- ●Sample contamination during collection or handling
- ●Insufficient DNA quantity or quality in the blood sample
- ●Previous blood transfusions or bone marrow transplants may affect results
- ●Technical errors in NGS sequencing or data analysis
Compare With Similar Tests
| Test | ALDH2 Gene Acute Alcohol sensitivity NGS Genetic Test | ALDH2 Enzyme Activity Assay | Alcohol Dehydrogenase (ADH) Genetic Test | Comprehensive Metabolic Panel | Ethanol Challenge Test |
|---|---|---|---|---|---|
| Comparison | ALDH2 Gene Acute Alcohol sensitivity NGS Genetic Test |
Frequently Asked Questions
What is the ALDH2 Gene Acute Alcohol Sensitivity Test?
Who should consider this test?
What are the common symptoms of acute alcohol sensitivity?
How is the test performed?
What is the cost of the test?
Is home sample collection available?
How long does it take to get results?
What do the test results indicate?
Are there any risks associated with the test?
Can the test detect all mutations related to alcohol sensitivity?
Is genetic counseling required after testing?
How can I book the test?
Related Tests
Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
Book Your Test
Enter your details and we'll connect you within 15 minutes.