ALPL Gene Odontohypophosphatasia NGS Genetic Test
Short Name: ALPL Gene OH Test
Also known as: Odontohypophosphatasia NGS Test, ALPL Genetic Test, Hypophosphatasia Genetic Test
ALPL Gene Odontohypophosphatasia NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Results are typically available within 3 to 4 weeks after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the ALPL Gene Odontohypophosphatasia NGS Genetic Test is to identify mutations in the ALPL gene for the accurate diagnosis of Odontohypophosphatasia. This enables early intervention, personalized treatment plans, and genetic counseling for affected individuals and their families.
- Test Code
- 2191
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- Results are typically available within 3 to 4 weeks after sample receipt.
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
Obtain a detailed clinical history of the patient, including symptoms and family history. A genetic counseling session is recommended to draw a pedigree chart of affected family members.
Method: Blood draw or Saliva collection
Laboratory Analysis
Sample collection involves a simple blood draw or saliva collection, performed by a trained phlebotomist at home or in a clinic. Ensure proper labeling and handling of samples.
Report Delivery
Samples are sent to the laboratory for DNA extraction and NGS analysis. Results are compiled into a comprehensive report and delivered via the chosen method.
Timeline: Results are typically available within 3 to 4 weeks after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the ALPL Gene Odontohypophosphatasia NGS Genetic Test is to identify mutations in the ALPL gene for the accurate diagnosis of Odontohypophosphatasia. This enables early intervention, personalized treatment plans, and genetic counseling for affected individuals and their families.
How to Prepare
- Use sterile equipment for blood collection or provide saliva in a designated kit
- Label samples correctly with patient details
- Store samples at ambient temperature as specified
- Avoid contamination by following standard precautions
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Early genetic testing for ALPL gene mutations is crucial for timely diagnosis and management of Odontohypophosphatasia, helping to prevent complications and improve quality of life."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood samples
- Incorrectly labeled or insufficient sample volume
- Samples not stored as per guidelines
Understanding Your Results
Positive for pathogenic mutation
Confirms diagnosis of Odontohypophosphatasia; genetic counseling and management recommended
Negative for pathogenic mutation
No ALPL gene mutations detected; consider alternative diagnoses or additional testing
Variant of uncertain significance
Further evaluation and family studies may be needed for clarification
Consult a healthcare provider or geneticist if you or a family member experiences symptoms such as delayed tooth development, bone pain, fractures, or if there is a family history of Odontohypophosphatasia. Seek advice for result interpretation and management.
Limitations
- ⚠May not detect all possible genetic variants or mutations
- ⚠Results require interpretation by a geneticist or healthcare provider
- ⚠Does not replace clinical evaluation and other diagnostic tests
Risks & Considerations
- ●Minimal risk from blood draw, such as slight bruising or infection
- ●No significant risks from saliva collection
Interfering Factors
- ●Poor sample quality or insufficient DNA
- ●Contamination during sample collection or handling
- ●Recent blood transfusions may affect DNA analysis
Compare With Similar Tests
| Test | ALPL Gene Odontohypophosphatasia NGS Genetic Test | ALPL Gene Sanger Sequencing | Hypophosphatasia Biochemical Test | Whole Exome Sequencing | Prenatal Genetic Testing |
|---|---|---|---|---|---|
| Comparison | ALPL Gene Odontohypophosphatasia NGS Genetic Test |
Frequently Asked Questions
What is Odontohypophosphatasia?
Who should take the ALPL Gene Odontohypophosphatasia NGS Genetic Test?
How is the test performed?
What is the cost of the test?
Is home sample collection available?
How long does it take to get results?
What do positive results mean?
Are there any risks associated with the test?
Can the test detect all mutations?
Is genetic counseling required?
What is the sample type for the test?
How should I prepare for the test?
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Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
Your Data Privacy
Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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