AML PANEL (Cytogenetics + FISH [AML/ETO, inv(16), PML/RARA, MLL]) Test
Short Name: AML Panel
Also known as: AML FISH Panel, Leukemia FISH Panel, AML Cytogenetics Panel
AML PANEL (Cytogenetics + FISH [AML/ETO, inv(16), PML/RARA, MLL]) Test test available at DNA Labs India for ₹18,000. Uses Cell Culture, Fluorescence In Situ Hybridization (FISH) on Bone marrow / Peripheral blood samples. Results in Results are typically available within 10 days after sample receipt.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of the AML Panel is to identify specific genetic abnormalities that aid in the diagnosis, risk stratification, and therapeutic management of Acute Myeloid Leukemia. It helps in distinguishing AML subtypes, predicting prognosis, and selecting targeted therapies. For example, detection of PML-RARA confirms APL and guides the use of differentiation therapy. The panel also assists in monitoring minimal residual disease and detecting relapse.
- Test Code
- 6032
- CPT Code
- 88237, 88271, 88275, 88291
- ICD Code
- C92.00
- Price
- ₹18,000
- Sample Type
- Bone marrow / Peripheral blood
- Result Time
- Results are typically available within 10 days after sample receipt.
- Fasting Required
- No
- Method
- Cell Culture, Fluorescence In Situ Hybridization (FISH)
Sample Collection
No special preparation required. Inform your doctor about any medications, especially anticoagulants or chemotherapy. A doctor's prescription is mandatory.
Method: Venipuncture or Bone Marrow Aspiration
Laboratory Analysis
Sample collection involves a bone marrow aspiration or blood draw. You may feel minor discomfort. The procedure is performed by trained personnel.
Report Delivery
Apply pressure to the puncture site to prevent bleeding. You can resume normal activities immediately. Report any unusual bleeding or infection at the site.
Timeline: Results are typically available within 10 days after sample receipt.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the AML Panel is to identify specific genetic abnormalities that aid in the diagnosis, risk stratification, and therapeutic management of Acute Myeloid Leukemia. It helps in distinguishing AML subtypes, predicting prognosis, and selecting targeted therapies. For example, detection of PML-RARA confirms APL and guides the use of differentiation therapy. The panel also assists in monitoring minimal residual disease and detecting relapse.
How to Prepare
- Bone marrow aspirate: collect in sodium heparin tube, transport at room temperature immediately
- Peripheral blood: collect 2 ml in sodium heparin vacutainer, transport on cool pack
- Label the sample with patient name, ID, and date of collection
- Do not refrigerate bone marrow samples; keep at room temperature
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"This panel is essential for risk stratification and targeted therapy selection in AML. Early detection of recurrent genetic abnormalities significantly impacts prognosis."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Clotted sample
- Hemolyzed sample
- Incorrect anticoagulant (e.g., EDTA instead of heparin)
- Sample received after 48 hours
- Unlabeled or mislabeled sample
Understanding Your Results
t(8;21) / AML1-ETO positive
Core-binding factor AML, favorable prognosis, high remission rate with high-dose cytarabine
inv(16) / CBFB-MYH11 positive
Core-binding factor AML, favorable prognosis, associated with myelomonocytic differentiation
t(15;17) / PML-RARA positive
Acute promyelocytic leukemia (APL), highly responsive to ATRA and arsenic trioxide, excellent prognosis
MLL (11q23) rearrangement positive
High-risk AML, often therapy-related, poor prognosis, may require allogeneic stem cell transplant
Normal karyotype and negative FISH
No recurrent genetic abnormality detected; further molecular testing may be needed for risk stratification
Consult your oncologist if you experience symptoms such as persistent fever, fatigue, easy bruising, bleeding, bone pain, or unexplained weight loss. Early diagnosis and treatment are critical for AML.
Limitations
- ⚠FISH only detects specific known rearrangements; other cryptic abnormalities may be missed
- ⚠Cytogenetic analysis requires viable cells; culture failure may occur
- ⚠Results should be interpreted in conjunction with morphology and clinical findings
- ⚠Not a screening test for general population; only for suspected AML
Risks & Considerations
- ●Bone marrow aspiration: rare risk of bleeding, infection, or discomfort
- ●Blood draw: minimal risk of bruising or hematoma
- ●FISH and cytogenetics have no direct risks to the patient
Interfering Factors
- ●Inadequate sample volume or poor quality DNA/RNA
- ●Delayed transport leading to cell degradation
- ●Recent blood transfusion (may dilute abnormal cells)
- ●Clotted sample (if anticoagulant not mixed properly)
- ●Prior chemotherapy or radiation may affect cytogenetic results
Compare With Similar Tests
| Test | AML PANEL (Cytogenetics + FISH [AML/ETO, inv(16), PML/RARA, MLL]) | AML Molecular Panel (NGS) | Flow Cytometry for AML | Conventional Cytogenetics only |
|---|---|---|---|---|
| Comparison | AML PANEL (Cytogenetics + FISH [AML/ETO, inv(16), PML/RARA, MLL]) | Detects gene mutations (e.g., FLT3, NPM1, CEBPA) in addition to chromosomal abnormalities. More comprehensive but higher cost and longer turnaround. | Immunophenotyping to identify blast lineage, but does not detect genetic abnormalities. | Karyotyping alone may miss small rearrangements; FISH adds sensitivity for specific translocations. |
Frequently Asked Questions
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Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
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