Angiotensin II Test
Short Name: Angiotensin II
Also known as: Angiotensin II Blood Test, Angiotensin II Level Test, Angiotensin II Serum Test, RAAS Angiotensin II Test
Angiotensin II Test test available at DNA Labs India for ₹13,000. Uses Radioimmunoassay on Plasma samples. Results in Samples are dispatched to the reference laboratory by the 7th of each month. Results are available 2-3 weeks after sample dispatch and can be accessed through the DNA Labs India online portal, email, or WhatsApp.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Ramarao Paidisetty
Consultant Biochemist · Reg: 21504
Last reviewed: September 7, 2026
Overview
The Angiotensin II test is primarily used to evaluate the function of the renin-angiotensin-aldosterone system (RAAS) and to help diagnose conditions related to abnormal blood pressure regulation and fluid-electrolyte balance. It assists physicians in identifying the underlying causes of resistant hypertension, differentiating between primary and secondary hypertension, assessing suspected renal artery stenosis, monitoring the effectiveness of RAAS-modulating medications such as ACE inhibitors and angiotensin II receptor blockers (ARBs), and evaluating electrolyte disturbances involving sodium and potassium. The test is also used in the investigation of renal function disorders and in the comprehensive assessment of cardiovascular health when RAAS dysfunction is clinically suspected.
- Test Code
- 133
- ICD Code
- I10
- Price
- ₹13,000
- Sample Type
- Plasma
- Result Time
- Samples are dispatched to the reference laboratory by the 7th of each month. Results are available 2-3 weeks after sample dispatch and can be accessed through the DNA Labs India online portal, email, or WhatsApp.
- Fasting Required
- No
- Method
- Radioimmunoassay
Sample Collection
Inform your physician about all medications you are currently taking, especially ACE inhibitors, ARBs, diuretics, beta-blockers, NSAIDs, or corticosteroids. Your doctor may advise temporarily discontinuing certain medications before the test. Maintain a controlled sodium diet as instructed. A duly filled Test Send Out Consent Form (Form 35) is mandatory. No routine fasting is required unless specifically advised by your physician.
Method: Venipuncture
Laboratory Analysis
A trained phlebotomist will collect approximately 2 mL of blood from a vein in your arm using a standard venipuncture technique. The blood is transferred into a Lavender Top (EDTA) tube. The patient's posture (supine or upright) at the time of collection should be documented, as it directly affects results.
Report Delivery
Apply gentle pressure to the puncture site with cotton or a bandage for a few minutes. Mild bruising at the site is normal and typically resolves on its own. Resume normal activities unless advised otherwise. The sample will be shipped refrigerated or frozen to the reference laboratory for analysis.
Timeline: Samples are dispatched to the reference laboratory by the 7th of each month. Results are available 2-3 weeks after sample dispatch and can be accessed through the DNA Labs India online portal, email, or WhatsApp.
Patient Instructions
About This Test
Who Should Get This Test
The Angiotensin II test is primarily used to evaluate the function of the renin-angiotensin-aldosterone system (RAAS) and to help diagnose conditions related to abnormal blood pressure regulation and fluid-electrolyte balance. It assists physicians in identifying the underlying causes of resistant hypertension, differentiating between primary and secondary hypertension, assessing suspected renal artery stenosis, monitoring the effectiveness of RAAS-modulating medications such as ACE inhibitors and angiotensin II receptor blockers (ARBs), and evaluating electrolyte disturbances involving sodium and potassium. The test is also used in the investigation of renal function disorders and in the comprehensive assessment of cardiovascular health when RAAS dysfunction is clinically suspected.
How to Prepare
- A duly filled Test Send Out Consent Form (Form 35) is mandatory before sample collection
- Inform the phlebotomist about your current posture status (supine or upright) for result interpretation
- Inform your physician about all current medications before sample collection
- Avoid strenuous physical activity for at least 30 minutes before sample collection
- Maintain a normal sodium diet for at least 3 days before the test unless otherwise directed
- Sample volume required: 2 mL (1 mL minimum) plasma collected in a Lavender Top (EDTA) tube
Doctor's Notes
Reviewed by Dr Ramarao Paidisetty — MBBS, MD (Biochemistry) · Reg. No. 21504
"The Angiotensin II test is an important diagnostic tool for evaluating the renin-angiotensin-aldosterone system (RAAS). It is particularly useful when investigating the underlying causes of resistant hypertension, suspected renal artery stenosis, or electrolyte imbalances. Elevated or suppressed Angiotensin II levels, when interpreted alongside renin and aldosterone values, can guide treatment decisions including the use of ACE inhibitors or ARBs. This test is typically ordered in conjunction with clinical assessment rather than as a standalone screening tool. Patients should consult their endocrinologist or treating physician to understand the implications of their results in the context of their overall health profile."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample collected in incorrect tube type (non-EDTA)
- Insufficient sample volume (less than 1 mL plasma)
- Sample not shipped under appropriate temperature conditions
- Missing or incomplete Test Send Out Consent Form (Form 35)
- Sample received beyond the stability window
- Hemolyzed or lipemic specimen
Understanding Your Results
High levels may indicate renovascular hypertension, renal artery stenosis, heart failure, cirrhosis with ascites, volume depletion, or a low-sodium diet. Elevated Angiotensin II stimulates aldosterone release, causing sodium retention and potassium loss.
Low levels may suggest primary aldosteronism (Conn's syndrome) where autonomous aldosterone production suppresses renin and angiotensin II, or may result from high-sodium diet, use of ACE inhibitors or ARBs, or certain rare genetic conditions affecting RAAS components.
Results within the reference range suggest normal RAAS function. However, clinical correlation is necessary as some conditions may present with normal Angiotensin II in the context of other abnormal findings.
Consult your physician or endocrinologist if your Angiotensin II test results are outside the normal reference range, if you experience persistent high blood pressure that does not respond to treatment, recurrent episodes of dizziness or fainting, unexplained electrolyte imbalances, excessive thirst, signs of dehydration, or symptoms suggestive of kidney dysfunction. Your doctor will evaluate the results in conjunction with other clinical findings and recommend appropriate management or further testing.
Limitations
- ⚠This is a send-out test; results are available only after 2-3 weeks from sample dispatch date (samples collected by the 7th of each month)
- ⚠Angiotensin II levels fluctuate based on posture, sodium intake, and time of day, making standardization of collection conditions critical
- ⚠Single measurement may not capture dynamic RAAS activity; clinical correlation is essential
- ⚠Reference ranges may vary between laboratories due to differences in assay methodology
- ⚠The test should be interpreted in conjunction with renin activity and aldosterone levels for comprehensive RAAS assessment
- ⚠A duly filled Test Send Out Consent Form (Form 35) is mandatory for sample processing
Risks & Considerations
- ●Minor bruising or hematoma at the venipuncture site
- ●Slight pain or discomfort during blood draw
- ●Rare risk of infection at the puncture site
- ●Lightheadedness or dizziness during or after blood collection
- ●No significant long-term risks associated with the test
Interfering Factors
- ●Medications such as ACE inhibitors, ARBs, diuretics, beta-blockers, NSAIDs, and corticosteroids can significantly alter Angiotensin II levels
- ●Sodium intake and dietary salt levels affect RAAS activity and test outcomes
- ●Patient posture during sample collection (supine vs. upright) influences results
- ●Pregnancy can physiologically elevate Angiotensin II levels
- ●Dehydration or volume depletion may cause falsely elevated results
- ●Recent blood transfusion or IV fluid administration may affect plasma composition
Compare With Similar Tests
| Test | Angiotensin II Test | Renin Activity Test | Aldosterone Test | Renin-Aldosterone Ratio (ARR) | Serum Electrolytes (Sodium and Potassium) |
|---|---|---|---|---|---|
| Comparison | Angiotensin II Test | The Renin Activity Test measures plasma renin activity (PRA), which reflects the rate at which angiotensinogen is converted to angiotensin I. While the Angiotensin II test measures the end-product hormone, the renin test evaluates the initiating enzyme activity. Both tests are complementary and often ordered together to assess the full RAAS pathway. | The Aldosterone Test measures aldosterone levels in blood or urine. Aldosterone is the downstream hormone stimulated by angiotensin II. While the Angiotensin II test evaluates the vasoconstrictive and signaling component of RAAS, the aldosterone test assesses the mineralocorticoid response. Both are used together to calculate the aldosterone-to-renin ratio (ARR) for primary aldosteronism screening. | The ARR is a calculated ratio used as a screening tool for primary aldosteronism. Unlike the standalone Angiotensin II test, ARR combines aldosterone and renin measurements to detect autonomous aldosterone production. The Angiotensin II test provides additional information about RAAS activity that complements ARR findings. | Serum electrolyte panels measure sodium and potassium levels directly. Elevated Angiotensin II typically promotes sodium retention and potassium excretion through aldosterone. Electrolyte testing is a routine first-line investigation that may prompt further RAAS-specific testing including the Angiotensin II test when abnormal patterns are detected. |
Frequently Asked Questions
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