Anti Cyclic Citrullinated Peptide (Anti CCP) Test
Short Name: Anti-CCP Test
Also known as: Anti-CCP Antibody Test, CCP Antibody Test, Anti-CCP IgG Test, Cyclic Citrullinated Peptide Antibody Test, ACPA Test
Anti Cyclic Citrullinated Peptide (Anti CCP) Test test available at DNA Labs India for ₹3,000. Uses Chemiluminescent Microparticle Immunoassay (CMIA) on Serum samples. Results in Same day to 24 hours. Free home collection in 300+ cities across India.
Overview
The Anti-CCP test is primarily used for the diagnosis and prognosis of rheumatoid arthritis. It aids clinicians in confirming an RA diagnosis when patients present with symptoms such as joint pain, swelling, and morning stiffness. The test is also used for prognostic assessment, as higher levels of anti-CCP antibodies are often associated with more severe and erosive forms of rheumatoid arthritis. Additionally, anti-CCP antibodies can sometimes be detected before the onset of clinical symptoms, making this test valuable for early detection and proactive management. The Anti-CCP test is typically ordered alongside the Rheumatoid Factor (RF) test, as using both together increases diagnostic accuracy for rheumatoid arthritis.
- Test Code
- 138
- CPT Code
- 86200
- ICD Code
- M05.9,M06.9
- Price
- ₹3,000
- Sample Type
- Serum
- Result Time
- Same day to 24 hours
- Fasting Required
- No
- Method
- Chemiluminescent Microparticle Immunoassay (CMIA)
Sample Collection
No special preparation such as fasting is required before the Anti-CCP test. Inform your healthcare provider about any medications, especially immunosuppressants or corticosteroids, as they may influence results. Stay hydrated and wear clothing with easy access to the inner elbow for blood draw.
Method: Venipuncture
Laboratory Analysis
A trained phlebotomist will collect approximately 2 mL of blood from a vein in your arm using a sterile needle and a Serum Separator Tube (SST). The procedure typically takes less than 5 minutes. You may feel a brief pinch during needle insertion. Home collection is available free of charge for online bookings.
Report Delivery
After blood collection, slight bruising or soreness at the puncture site is normal and usually resolves within 1-2 days. Apply gentle pressure with a cotton ball. Avoid heavy lifting with the affected arm for a few hours. No post-test restrictions apply. Your results will be available within 24 hours and can be accessed through the online portal, email, or WhatsApp.
Timeline: Same day to 24 hours
Patient Instructions
About This Test
Who Should Get This Test
The Anti-CCP test is primarily used for the diagnosis and prognosis of rheumatoid arthritis. It aids clinicians in confirming an RA diagnosis when patients present with symptoms such as joint pain, swelling, and morning stiffness. The test is also used for prognostic assessment, as higher levels of anti-CCP antibodies are often associated with more severe and erosive forms of rheumatoid arthritis. Additionally, anti-CCP antibodies can sometimes be detected before the onset of clinical symptoms, making this test valuable for early detection and proactive management. The Anti-CCP test is typically ordered alongside the Rheumatoid Factor (RF) test, as using both together increases diagnostic accuracy for rheumatoid arthritis.
How to Prepare
- No fasting required before the test
- Stay well hydrated before sample collection
- Inform the phlebotomist about any current medications or supplements
- Wear short-sleeved or loose-fitting clothing for easy arm access
- Remain seated for a few minutes after blood draw to avoid dizziness
Doctor's Notes
"Anti-CCP antibody testing is one of the most specific serological markers available for rheumatoid arthritis. A positive result, especially in combination with clinical symptoms such as joint stiffness, swelling, and pain, strongly supports an RA diagnosis. Early detection through Anti-CCP testing allows rheumatologists to initiate disease-modifying therapy promptly, which can significantly reduce joint damage and improve long-term outcomes. I recommend this test for any patient presenting with unexplained polyarthritis or morning stiffness lasting more than 30 minutes."
Test Parameters & Specifications
Sample Stability
- Hemolyzed samples
- Specimens collected in incorrect tube type (non-SST)
- Samples received at room temperature beyond 2 hours
- Insufficient sample volume (less than 1 mL serum)
- Unlabeled or mismatched samples
Understanding Your Results
< 20 U/mL
Anti-CCP antibodies are not detected. RA is less likely but cannot be completely ruled out in the presence of strong clinical symptoms.
20–39 U/mL
Low levels of anti-CCP antibodies detected. Correlate with clinical findings and other tests such as RF, ESR, and CRP.
40–59 U/mL
Moderate levels of anti-CCP antibodies. Strongly suggestive of rheumatoid arthritis. Evaluate for early erosive disease.
≥ 60 U/mL
High levels of anti-CCP antibodies. Highly specific for rheumatoid arthritis. Associated with more aggressive and erosive disease course.
Consult a rheumatologist if your Anti-CCP test result is positive, especially if you are experiencing joint pain, stiffness, swelling, or fatigue. A positive result warrants further clinical evaluation, including imaging studies and additional laboratory tests, to confirm the diagnosis and initiate appropriate treatment. Early consultation can help prevent joint damage and improve outcomes.
Limitations
- ⚠A negative Anti-CCP result does not completely rule out rheumatoid arthritis
- ⚠The test should not be used as the sole diagnostic criterion; clinical evaluation and additional tests are necessary
- ⚠Approximately 20-30% of RA patients may be seronegative for anti-CCP antibodies
- ⚠Anti-CCP antibodies may be present in other autoimmune conditions at low titers, though rarely
Risks & Considerations
- ●Minor bruising or pain at the needle site
- ●Slight risk of infection at the puncture site
- ●Rarely, fainting or dizziness during blood draw
Interfering Factors
- ●Hemolyzed or lipemic samples may affect results
- ●Recent blood transfusions could interfere with antibody detection
- ●Immunosuppressive therapy may reduce antibody levels
- ●Rheumatoid Factor (IgM) can cause false-positive results in some assay systems
Compare With Similar Tests
| Test | Anti Cyclic Citrullinated Peptide (Anti CCP) Test | |||||
|---|---|---|---|---|---|---|
| Comparison | Anti Cyclic Citrullinated Peptide (Anti CCP) Test |
Frequently Asked Questions
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