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APOA2 Gene Hypercholesterolemia, familial, modifier of NGS Genetic Test

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APOA2 Gene Hypercholesterolemia, familial, modifier of NGS Genetic Test

Short Name: APOA2 Gene Hypercholesterolemia Modifier Test

Also known as: Apolipoprotein A-II Gene Test, APOA2 Mutation Analysis

APOA2 Gene Hypercholesterolemia, familial, modifier of NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks from sample receipt. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

To diagnose familial hypercholesterolemia by detecting pathogenic mutations in the APOA2 gene, enabling early intervention and risk management for cardiovascular diseases.

Test Code
2078
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks from sample receipt
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Provide detailed clinical and family history. Genetic counseling session recommended to discuss implications.

Method: Venipuncture or FTA card collection

Step 2

Laboratory Analysis

Standard blood draw using venipuncture or collection on FTA card by a trained professional.

Step 3

Report Delivery

Apply pressure to the puncture site. Store sample as per instructions for stability.

Timeline: 3 to 4 weeks from sample receipt

Patient Instructions

1
Before the Test:Genetic counseling to assess need and understand implications. No specific preparation required for sample collection.
2
During the Test:Blood sample drawn and sent to lab for NGS analysis of APOA2 gene.
3
After the Test:Results delivered via online portal, email, or WhatsApp. Follow-up counseling recommended for interpretation.

About This Test

Who Should Get This Test

To diagnose familial hypercholesterolemia by detecting pathogenic mutations in the APOA2 gene, enabling early intervention and risk management for cardiovascular diseases.

How to Prepare

  • Ensure patient provides informed consent
  • Collect sample using sterile technique
  • Label sample correctly with patient details
  • Transport sample to lab under appropriate conditions

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"Early genetic testing for APOA2 gene mutations can help in managing familial hypercholesterolemia and preventing cardiovascular complications through personalized treatment."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture or FTA card collection

Sample Stability

Blood: stable for 24-48 hours at room temperature
DNA: stable for several years if stored at -20°C
FTA card: stable for years at room temperature if dry
Sample Rejection Criteria:
  • Hemolyzed or clotted blood sample
  • Insufficient sample volume
  • Improperly labeled or unlabeled sample
  • Sample collected without proper consent

Understanding Your Results

Results indicate the presence or absence of mutations in the APOA2 gene associated with familial hypercholesterolemia. Positive results suggest increased genetic risk, while negative results indicate no detected mutations in this gene.
Positive for APOA2 mutation: Indicates genetic predisposition to hypercholesterolemia; recommend lifestyle changes, monitoring, and possible medication.
Negative for APOA2 mutation: No mutation detected in APOA2 gene; clinical symptoms may be due to other genetic or non-genetic factors.
Variant of Uncertain Significance (VUS): Further evaluation and family studies may be needed for interpretation.
⚠️ When to Consult a Doctor:

If test results are positive or if symptoms of hypercholesterolemia persist despite negative results. Also, consult for genetic counseling and family planning advice.

Limitations

  • ⚠Only detects mutations in the APOA2 gene; does not cover all genetic causes of hypercholesterolemia
  • ⚠Results require clinical correlation and genetic counseling
  • ⚠May not identify novel or rare variants of uncertain significance

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Psychological impact of genetic results, requiring counseling

Interfering Factors

  • ●Sample degradation or contamination
  • ●Improper sample collection or handling
  • ●Technical issues during NGS sequencing

Compare With Similar Tests

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ComparisonAPOA2 Gene Hypercholesterolemia, familial, modifier of NGS Genetic Test

Frequently Asked Questions

What is the APOA2 Gene Hypercholesterolemia NGS Genetic Test?
It is a genetic test using Next-Generation Sequencing to detect mutations in the APOA2 gene associated with familial hypercholesterolemia.
Who should consider taking this test?
Individuals with high LDL cholesterol, family history of hypercholesterolemia, or symptoms of cardiovascular disease.
What is the cost of the test at DNA Labs India?
The test costs INR 20,000, with home collection available across India.
How is the test performed?
A blood sample is collected and analyzed using NGS technology to identify APOA2 gene mutations.
What sample is required for the test?
Blood, extracted DNA, or one drop of blood on an FTA card.
How long does it take to get the results?
Results are typically available in 3 to 4 weeks.
Is the test accurate?
Yes, NGS technology provides high accuracy for detecting genetic mutations in the APOA2 gene.
What do the test results mean?
Results indicate if pathogenic mutations in the APOA2 gene are present, suggesting increased risk for hypercholesterolemia.
Can the test be done at home?
Yes, DNA Labs India offers free home sample collection for online bookings.
Is genetic counseling necessary before or after the test?
Yes, counseling is recommended to understand implications and interpret results.
What are the risks of the test?
Risks are minimal, primarily related to blood draw, but genetic results may have psychological impacts requiring professional support.
How can I book the test?
Book online through DNA Labs India's website or contact them via phone or WhatsApp for quick scheduling.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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