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APOL1 Gene Focal segmental glomerulosclerosis type 4, susceptibility to NGS Genetic Test

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APOL1 Gene Focal segmental glomerulosclerosis type 4, susceptibility to NGS Genetic Test

Short Name: APOL1 FSGS Type 4 NGS Test

Also known as: APOL1 Gene Mutation Test, FSGS Type 4 Genetic Test, APOL1 Susceptibility Test

APOL1 Gene Focal segmental glomerulosclerosis type 4, susceptibility to NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To detect mutations in the APOL1 gene that increase susceptibility to Focal Segmental Glomerulosclerosis Type 4, aiding in risk assessment, early diagnosis, and personalized management of kidney disease.

Test Code
5390
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation required. Genetic counseling recommended prior to testing.

Method: Venipuncture or Saliva Collection

Step 2

Laboratory Analysis

Sample collected via blood draw or saliva collection in a clinical or home setting.

Step 3

Report Delivery

Apply pressure to the puncture site if blood is drawn. Store sample as instructed.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Consult with a genetic counselor to discuss implications, provide informed consent, and draw a family pedigree chart.
2
During the Test:Sample collection is quick and non-invasive, involving a blood draw or saliva sample.
3
After the Test:Wait for results, which will be delivered online. Follow up with a healthcare provider for interpretation and next steps.

About This Test

Who Should Get This Test

To detect mutations in the APOL1 gene that increase susceptibility to Focal Segmental Glomerulosclerosis Type 4, aiding in risk assessment, early diagnosis, and personalized management of kidney disease.

How to Prepare

  • Ensure sample is collected in a sterile container
  • Avoid eating or drinking for 30 minutes before saliva collection
  • Label sample correctly with patient details

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This test is crucial for individuals with a family history of FSGS or kidney disease to assess genetic risk, guide preventive care, and inform treatment decisions."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs per requirement
Collection MethodVenipuncture or Saliva Collection

Sample Stability

Blood sample stable for 48 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed or contaminated sample
  • Insufficient sample volume
  • Improper labeling or storage

Understanding Your Results

Results indicate the presence or absence of mutations in the APOL1 gene associated with FSGS susceptibility.
📊

Positive for APOL1 mutation

Increased genetic risk for developing FSGS Type 4; clinical monitoring and preventive measures recommended.

📊

Negative for APOL1 mutation

No known genetic susceptibility detected; other causes of kidney symptoms should be investigated.

⚠️ When to Consult a Doctor:

If you experience symptoms like proteinuria, hematuria, edema, or have a family history of kidney disease, consult a nephrologist or genetic counselor.

Limitations

  • ⚠Test only detects known mutations in the APOL1 gene
  • ⚠Does not predict disease onset, severity, or progression
  • ⚠Results should be interpreted in conjunction with clinical findings

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Potential psychological impact from genetic results; counseling recommended

Interfering Factors

  • ●Sample contamination
  • ●Technical errors in sequencing
  • ●Degraded DNA sample

Compare With Similar Tests

TestAPOL1 Gene Focal segmental glomerulosclerosis type 4, susceptibility to NGS Genetic TestKidney BiopsyUrine Protein Test
ComparisonAPOL1 Gene Focal segmental glomerulosclerosis type 4, susceptibility to NGS Genetic Test

Frequently Asked Questions

What is the APOL1 Gene FSGS Type 4 NGS Genetic Test?
It is a genetic test that uses Next-Generation Sequencing to detect mutations in the APOL1 gene, which increase the risk of developing Focal Segmental Glomerulosclerosis Type 4, a kidney disorder.
Who should consider taking this test?
Individuals with a family history of FSGS, unexplained kidney symptoms like proteinuria or edema, or those with chronic kidney disease of unknown cause should consider this test.
How is the test performed?
The test involves collecting a blood or saliva sample, which is analyzed in a laboratory using NGS technology to identify APOL1 gene mutations.
What is the cost of the test in India?
The cost is INR 20,000, which includes sample collection, analysis, and report delivery.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
Is the test painful?
No, the test is non-invasive and painless, involving a simple blood draw or saliva collection.
What do the results mean?
A positive result indicates a genetic mutation increasing FSGS risk, while a negative result means no known mutation was detected. Results should be interpreted by a healthcare professional.
Can this test diagnose FSGS?
No, this test assesses genetic susceptibility. A definitive diagnosis of FSGS requires clinical evaluation, urine tests, and sometimes a kidney biopsy.
Is genetic counseling required before the test?
Yes, genetic counseling is recommended to understand the test implications, provide informed consent, and discuss family history.
What are the risks of the test?
Risks are minimal, such as bruising from blood draw. There may be psychological impacts from results, so counseling is advised.
How accurate is the test?
The test is highly accurate for detecting known APOL1 mutations using NGS technology, but it does not guarantee disease development.
What should I do if I test positive?
If positive, consult a nephrologist for regular monitoring, lifestyle modifications, and potential preventive treatments to manage kidney health.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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