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ARNT2 Gene Webb-Dattani syndrome NGS Genetic Test

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ARNT2 Gene Webb-Dattani syndrome NGS Genetic Test

Short Name: ARNT2 NGS Test

Also known as: ARNT2 gene sequencing, Webb-Dattani syndrome genetic test

ARNT2 Gene Webb-Dattani syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS (Next Generation Sequencing)Pediatric🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this NGS genetic test is to confirm or rule out a diagnosis of Webb-Dattani syndrome by identifying pathogenic mutations in the ARNT2 gene. It aids in differentiating this condition from other similar genetic disorders, guiding clinical management, and enabling accurate genetic counseling for affected families.

Test Code
5983
CPT Code
81407
ICD Code
Q87.89
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

No fasting required. Please provide clinical history and any previous genetic test results. A genetic counseling session is recommended before the test.

Method: Venipuncture or FTA card

Step 2

Laboratory Analysis

Blood sample will be collected by a trained phlebotomist. For FTA card, a few drops of blood are placed on the card.

Step 3

Report Delivery

No special precautions. You can resume normal activities immediately.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:No special preparation. A genetic counseling session is recommended to discuss the implications of the test.
2
During the Test:A blood sample is drawn. The procedure is quick and minimally invasive.
3
After the Test:You can resume normal activities. Results are typically available in 3-4 weeks.

About This Test

Who Should Get This Test

The purpose of this NGS genetic test is to confirm or rule out a diagnosis of Webb-Dattani syndrome by identifying pathogenic mutations in the ARNT2 gene. It aids in differentiating this condition from other similar genetic disorders, guiding clinical management, and enabling accurate genetic counseling for affected families.

How to Prepare

  • Use EDTA vacutainer for blood collection
  • For FTA card, ensure proper drying and labeling
  • Transport sample at ambient temperature
  • Avoid hemolysis

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic diagnosis of Webb-Dattani syndrome is crucial for managing developmental delays and endocrine abnormalities. This NGS test provides a definitive answer, enabling timely intervention and family counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume2-3 ml blood
ContainerEDTA vacutainer
Collection MethodVenipuncture or FTA card

Sample Stability

Blood: 24 hours at room temperature
Extracted DNA: 1 week at 2-8°C
FTA card: stable for months at room temperature
Sample Rejection Criteria:
  • Hemolyzed or clotted blood sample
  • Insufficient quantity
  • Improper labeling
  • Sample received after prolonged transit (>48 hours) without proper storage

Understanding Your Results

The interpretation of the ARNT2 gene NGS test results should be performed by a qualified geneticist. The presence of a pathogenic or likely pathogenic variant confirms the diagnosis of Webb-Dattani syndrome. A negative result does not completely rule out the condition, as mutations may be missed by this technique.
📊

Pathogenic variant detected

Confirms diagnosis of Webb-Dattani syndrome. Genetic counseling recommended for family.

📊

Likely pathogenic variant detected

Highly suggestive of the condition; further segregation analysis may be helpful.

📊

Variant of uncertain significance (VUS)

Cannot determine clinical significance; additional testing or family studies may be needed.

📊

No pathogenic variant detected

Does not rule out the syndrome; consider other genetic causes or re-evaluation.

⚠️ When to Consult a Doctor:

Consult a pediatrician or geneticist if your child has unexplained short stature, developmental delays, or features suggestive of a genetic syndrome. Early diagnosis can significantly improve management.

Limitations

  • ⚠NGS may not detect large deletions/duplications or deep intronic variants
  • ⚠Variant of uncertain significance (VUS) may require further analysis
  • ⚠Test does not assess other genes associated with similar phenotypes
  • ⚠Results should be interpreted in the context of clinical findings

Risks & Considerations

  • ●Minimal risk of bruising or infection at the blood draw site
  • ●Psychological impact of genetic results
  • ●Potential for uncertain results (VUS)

Interfering Factors

  • ●Contaminated or degraded DNA sample
  • ●Insufficient sample quantity
  • ●Recent blood transfusion (within 2 weeks) may dilute DNA
  • ●Bone marrow transplant recipients may show mixed DNA

Compare With Similar Tests

TestARNT2 Gene Webb-Dattani syndrome NGS Genetic TestWhole Exome SequencingSanger Sequencing
ComparisonARNT2 Gene Webb-Dattani syndrome NGS Genetic TestWES analyzes all coding regions of genes, whereas this targeted NGS test focuses only on ARNT2. WES is more comprehensive but costlier and may yield incidental findings.Sanger is used for targeted single-gene sequencing but is less efficient for multiple genes. NGS is faster and more cost-effective for panel testing.

Frequently Asked Questions

What is Webb-Dattani syndrome?
Webb-Dattani syndrome is a rare genetic disorder caused by mutations in the ARNT2 gene, characterized by short stature, intellectual disability, developmental delays, and other features.
How is the ARNT2 gene test performed?
The test uses Next Generation Sequencing (NGS) on a blood sample or extracted DNA to identify mutations in the ARNT2 gene.
What is the cost of the ARNT2 gene test in India?
At DNA Labs India, the cost is INR 20,000, which includes genetic counseling and home sample collection.
Is fasting required for this test?
No, fasting is not required for this genetic test.
What is the turnaround time for results?
Results are typically available within 3 to 4 weeks after the sample is received.
Can this test be done on children?
Yes, this test is specifically designed for pediatric patients with symptoms suggestive of Webb-Dattani syndrome.
What sample types are accepted?
Blood, extracted DNA, or one drop of blood on an FTA card are accepted.
Is home sample collection available?
Yes, we offer free home sample collection across major cities in India for online bookings.
What does the test include?
The test includes NGS sequencing of the ARNT2 gene, a genetic counseling session, and a detailed report.
Are there any risks associated with the test?
The test is low-risk, with minimal discomfort from blood collection. Genetic results may have psychological implications.
Can this test detect all ARNT2 mutations?
NGS detects most mutations, but large deletions or deep intronic variants may not be identified. Further testing may be needed.
How should I prepare for the test?
No special preparation is needed. However, a genetic counseling session is recommended before the test.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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