Skip to main content
DNA Labs India

Beta Thalassemia-HBB Full Gene Analysis (Couple) Test

DNA Labs India | ISO 9001:2015 Certified

Beta Thalassemia-HBB Full Gene Analysis (Couple) Test

Short Name: Beta Thalassemia HBB Couple

Also known as: HBB Gene Analysis for Couples, Beta Thalassemia Carrier Screening (Couple)

Beta Thalassemia-HBB Full Gene Analysis (Couple) Test test available at DNA Labs India for ₹0. Uses Sanger Sequencing on Peripheral Blood samples. Results in Reports are typically delivered within 8-10 business days after sample receipt.. Free home collection in 300+ cities across India.

Molecular GeneticsAdult🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

The purpose of this test is to determine whether either partner carries a mutation in the HBB gene that could cause beta thalassemia in their offspring. It provides critical information for genetic counseling and reproductive planning.

Test Code
6054
CPT Code
81405
ICD Code
D56.1
Sample Type
Peripheral Blood
Result Time
Reports are typically delivered within 8-10 business days after sample receipt.
Fasting Required
No
Method
Sanger Sequencing
Step 1

Sample Collection

No special preparation required. A doctor's prescription is recommended. Inform the lab if you have had a blood transfusion recently.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in your arm. The procedure takes a few minutes.

Step 3

Report Delivery

You may resume normal activities immediately. Apply pressure to the puncture site to prevent bruising.

Timeline: Reports are typically delivered within 8-10 business days after sample receipt.

Patient Instructions

1
Before the Test:No special preparation. Bring your doctor's prescription if available.
2
During the Test:Blood sample collection by trained phlebotomist.
3
After the Test:No restrictions. Results will be available in 8-10 days.

About This Test

Who Should Get This Test

The purpose of this test is to determine whether either partner carries a mutation in the HBB gene that could cause beta thalassemia in their offspring. It provides critical information for genetic counseling and reproductive planning.

How to Prepare

  • Use EDTA vacutainer (2 ml)
  • Transport at cool pack temperature
  • Avoid hemolysis

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"Carrier screening for beta thalassemia is crucial for couples planning a family. This test provides definitive information to guide reproductive decisions."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypePeripheral Blood
Sample Volume2 ml
ContainerEDTA Vacutainer
Collection MethodVenipuncture

Sample Stability

Whole blood: 24 hours at 2-8°C
Extracted DNA: stable for months at -20°C
Sample Rejection Criteria:
  • Clotted or hemolyzed sample
  • Incorrect anticoagulant
  • Sample not labeled properly

Understanding Your Results

The test identifies mutations in the HBB gene. If a pathogenic variant is found in one allele, the individual is a carrier (beta thalassemia trait). If both partners are carriers, there is a 25% risk of having an affected child.
📊

Negative

No increased risk of beta thalassemia in offspring

📊

Carrier

Carrier status; if both partners are carriers, 25% risk of affected child

📊

Affected

Individual has beta thalassemia major or intermedia

⚠️ When to Consult a Doctor:

Consult a genetic counselor or gynecologist if you are a carrier or if both partners are carriers to discuss reproductive options.

Limitations

  • ⚠This test detects mutations in the HBB gene only; other thalassemia types are not covered
  • ⚠Rare deep intronic or regulatory mutations may not be detected by Sanger sequencing
  • ⚠Results should be interpreted in conjunction with hematological parameters and family history

Risks & Considerations

  • ●Minimal risk of bruising or infection at puncture site
  • ●Rare possibility of fainting during blood draw

Interfering Factors

  • ●Recent blood transfusion (within 2 weeks) may dilute DNA
  • ●Bone marrow transplantation can affect results
  • ●Contaminated or hemolyzed samples

Compare With Similar Tests

TestBeta Thalassemia-HBB Full Gene Analysis (Couple)Hemoglobin ElectrophoresisHBB Gene Targeted Mutation AnalysisNext-Generation Sequencing (NGS) Thalassemia Panel
ComparisonBeta Thalassemia-HBB Full Gene Analysis (Couple)

Frequently Asked Questions

What is the cost of Beta Thalassemia-HBB Full Gene Analysis (Couple)?
The cost is INR 20000, which includes genetic counseling and home sample collection.
What is the sample type required for this test?
Peripheral blood (2 ml) collected in an EDTA vacutainer.
Is fasting required before the test?
No, fasting is not required.
How long does it take to get the results?
Reports are available within 8-10 days.
Who should consider this test?
Couples planning pregnancy, especially those with a family history of beta thalassemia or belonging to high-risk ethnic groups.
What does a positive result mean?
A positive result indicates that the individual is a carrier of a beta thalassemia mutation. If both partners are carriers, there is a 25% risk of having an affected child.
Is genetic counseling included?
Yes, the test includes genetic counseling with a certified genetic counselor.
Can this test be done without a doctor's prescription?
A doctor's prescription is recommended, but not mandatory for this test.
Is home sample collection available?
Yes, free home sample collection is available for online bookings across major cities in India.
What is the difference between this test and a single person HBB analysis?
This test analyzes both partners simultaneously, providing a comprehensive risk assessment for the couple.
Are there any risks associated with the test?
The test involves a simple blood draw with minimal risks like bruising or infection.
Does this test detect all types of thalassemia?
No, it specifically analyzes the HBB gene for beta thalassemia. Other types like alpha thalassemia require different tests.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

Related Tests

FISH - Postnatal Gender Confirmation Test

₹6,000

Microarray 60K (POC) + Couple Karyotyping

₹18,000

Peripheral Blood for High Resolution Couple Karyotyping

₹7,600

Pre-Implantation Genetic Disorder/PGD (Single Embryo)

₹27,000

Pre-Implantation Genetic Disorder/PGD (Single Embryo) with Maternal DNA Contamination Check

₹37,500

Pre-Implantation Genetic Disorder/PGD (Single Gene Disorder- Known Mutation)- Baseline

₹45,000
For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

Book Your Test

Enter your details and we'll connect you within 15 minutes.

🧬

Quick Connect

Enter your mobile number and we’ll connect you with the team.

+91

✅ Connecting you now...

🔒 Your number is used to respond to this request.