Biopsy Muscle with Special Stains & IHC Test
Short Name: Muscle Biopsy with Special Stains & IHC
Also known as: Muscle Biopsy with Immunohistochemistry, Muscle Biopsy with Special Stains
Biopsy Muscle with Special Stains & IHC Test test available at DNA Labs India for ₹10,500. Uses Histopathology, Special stains, Immunohistochemistry (IHC) on Muscle tissue samples. Results in Reports are typically available within 10 days after the sample is received at the laboratory.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of this test is to diagnose muscle diseases by examining the microscopic structure of muscle tissue. It helps identify inflammation, degeneration, necrosis, and specific protein deficiencies that are characteristic of various myopathies. The results guide treatment planning and prognosis.
- Test Code
- 6064
- CPT Code
- 20200
- ICD Code
- M62.9
- Price
- ₹10,500
- Sample Type
- Muscle tissue
- Result Time
- Reports are typically available within 10 days after the sample is received at the laboratory.
- Fasting Required
- No
- Method
- Histopathology, Special stains, Immunohistochemistry (IHC)
Sample Collection
Inform your doctor about all medications you are taking, especially blood thinners. You may be advised to stop certain medications before the biopsy. No fasting is required. A doctor's prescription is mandatory.
Method: Surgical biopsy (open or needle) by a surgeon
Laboratory Analysis
The biopsy is performed under local anesthesia. A small incision is made to obtain a muscle tissue sample. The procedure is usually quick and causes minimal discomfort.
Report Delivery
You may experience mild soreness at the biopsy site. Keep the area clean and dry. Avoid strenuous activity for 24-48 hours. Follow your doctor's instructions for wound care.
Timeline: Reports are typically available within 10 days after the sample is received at the laboratory.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to diagnose muscle diseases by examining the microscopic structure of muscle tissue. It helps identify inflammation, degeneration, necrosis, and specific protein deficiencies that are characteristic of various myopathies. The results guide treatment planning and prognosis.
How to Prepare
- Tissue sample must be placed in a sterile container with saline-moistened gauze or 10% neutral buffered formalin
- Label the container with patient name, date, and site of biopsy
- Transport the sample to the laboratory as soon as possible
- Do not freeze the sample
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Muscle biopsy with special stains and IHC is a cornerstone in diagnosing neuromuscular disorders. It helps differentiate between inflammatory, dystrophic, and metabolic myopathies, guiding targeted therapy."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample not in appropriate fixative
- Sample frozen or dried out
- Inadequate tissue size
- Improper labeling
Understanding Your Results
Muscular dystrophy
Polymyositis
Dermatomyositis
Inclusion body myositis
Metabolic myopathy
Consult a doctor if you experience persistent muscle weakness, pain, or any symptoms suggestive of muscle disease. Early diagnosis can improve management and outcomes.
Limitations
- ⚠Biopsy may not be representative if the affected muscle is not sampled
- ⚠Some muscle diseases may show normal histology in early stages
- ⚠Interpretation requires correlation with clinical findings and other tests
- ⚠IHC may be inconclusive in rare genetic variants
Risks & Considerations
- ●Bleeding at the biopsy site
- ●Infection
- ●Bruising or swelling
- ●Nerve damage (rare)
- ●Allergic reaction to local anesthetic
Interfering Factors
- ●Recent intramuscular injections
- ●Electromyography (EMG) performed at the biopsy site
- ●Trauma or injury to the muscle
- ●Certain medications (e.g., statins, corticosteroids)
- ●Improper tissue handling or fixation
Compare With Similar Tests
| Test | Biopsy Muscle with Special Stains & IHC | Serum Creatine Kinase (CK) | Electromyography (EMG) | MRI of Muscle |
|---|---|---|---|---|
| Comparison | Biopsy Muscle with Special Stains & IHC | CK is a blood test that indicates muscle damage but is not specific. Muscle biopsy provides tissue diagnosis. | EMG assesses electrical activity of muscles and can identify abnormalities, but biopsy gives definitive histopathological diagnosis. | MRI can show muscle inflammation or fatty infiltration, but biopsy is needed for specific diagnosis. |
Frequently Asked Questions
What is the cost of Biopsy Muscle with Special Stains & IHC?
Is fasting required for this test?
How is the muscle biopsy sample collected?
What is the turnaround time for results?
Is home sample collection available?
What conditions can this test diagnose?
Do I need a doctor's prescription?
Are there any risks associated with the biopsy?
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Is the test covered by insurance?
What is the difference between special stains and IHC?
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