Biopsy Renal 3 Bottle (Paraffin, IF, and EM) Test
Short Name: Renal Biopsy 3 Bottle
Also known as: Kidney Biopsy 3 Bottle, Renal Biopsy with IF and EM
Biopsy Renal 3 Bottle (Paraffin, IF, and EM) Test test available at DNA Labs India for ₹16,500. Uses Histopathology, Immunofluorescence, Electron Microscopy on Tissue (Kidney biopsy) samples. Results in Preliminary light microscopy report may be available in 3-5 days. Final report including IF and EM may take up to 21 days.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Ramarao Paidisetty
Consultant Biochemist · Reg: 21504
Last reviewed: September 7, 2026
Overview
The purpose of this test is to diagnose the underlying cause of kidney dysfunction, assess the severity of kidney damage, guide treatment decisions, and monitor disease progression. It is often recommended when non-invasive tests (urine, blood) suggest significant renal pathology, or when a specific diagnosis is needed for conditions like nephrotic syndrome, acute kidney injury, or chronic kidney disease of unknown etiology.
- Test Code
- 6066
- CPT Code
- 50200
- ICD Code
- N00-N29
- Price
- ₹16,500
- Sample Type
- Tissue (Kidney biopsy)
- Result Time
- Preliminary light microscopy report may be available in 3-5 days. Final report including IF and EM may take up to 21 days.
- Fasting Required
- No
- Method
- Histopathology, Immunofluorescence, Electron Microscopy
Sample Collection
Inform your doctor about all medications, especially blood thinners (aspirin, warfarin, clopidogrel). You may be asked to stop them temporarily. Fasting is not required. A doctor's prescription is mandatory for this test.
Method: Ultrasound-guided percutaneous biopsy
Laboratory Analysis
You will lie on your stomach or side. The skin is cleaned and numbed with local anesthesia. Using ultrasound guidance, a thin needle is inserted through the skin into the kidney to obtain small tissue cores. You may feel pressure but not sharp pain. The procedure takes about 15-20 minutes.
Report Delivery
You will be observed for several hours to monitor for bleeding. Avoid strenuous activity and heavy lifting for at least 24-48 hours. Drink plenty of water to help flush out any blood. Report any severe pain, fever, or blood in urine to your doctor immediately.
Timeline: Preliminary light microscopy report may be available in 3-5 days. Final report including IF and EM may take up to 21 days.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to diagnose the underlying cause of kidney dysfunction, assess the severity of kidney damage, guide treatment decisions, and monitor disease progression. It is often recommended when non-invasive tests (urine, blood) suggest significant renal pathology, or when a specific diagnosis is needed for conditions like nephrotic syndrome, acute kidney injury, or chronic kidney disease of unknown etiology.
How to Prepare
- Ensure the three bottles are correctly labeled and contain the appropriate media
- Tissue should be placed in each bottle immediately after biopsy
- Samples must be transported to the laboratory at room temperature (do not refrigerate)
- Avoid freezing the samples
Doctor's Notes
Reviewed by Dr Ramarao Paidisetty — MBBS, MD (Biochemistry) · Reg. No. 21504
"A renal biopsy with three modalities (light microscopy, immunofluorescence, and electron microscopy) is essential for accurate diagnosis of glomerular diseases, guiding therapy and prognosis."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient tissue (less than 5 glomeruli)
- Incorrect fixative or media
- Sample leakage or contamination
- Improper labeling
- Delayed transport beyond stability period
Understanding Your Results
Minimal Change Disease
IgA Nephropathy
Membranous Nephropathy
Lupus Nephritis
Consult a nephrologist if you experience symptoms such as swelling, blood in urine, foamy urine, fatigue, or changes in urination. Early diagnosis and treatment can prevent progression to end-stage renal disease.
Limitations
- ⚠Sampling error: biopsy may miss focal lesions
- ⚠Interpretation requires specialized expertise
- ⚠EM processing may take longer (up to 21 days)
- ⚠Invasive procedure with inherent risks (bleeding, infection)
Risks & Considerations
- ●Bleeding (hematuria, perinephric hematoma)
- ●Infection
- ●Arteriovenous fistula
- ●Puncture of adjacent organs (rare)
- ●Pain at biopsy site
Interfering Factors
- ●Inadequate tissue sample (less than 5 glomeruli)
- ●Bleeding diathesis or anticoagulant therapy
- ●Uncontrolled hypertension
- ●Kidney infection or abscess
- ●Patient non-compliance during procedure
Compare With Similar Tests
| Test | Biopsy Renal 3 Bottle (Paraffin, IF, and EM) | Renal Biopsy (Paraffin only) | Renal Biopsy (Paraffin + IF) | Renal Biopsy (Paraffin + IF + EM) |
|---|---|---|---|---|
| Comparison | Biopsy Renal 3 Bottle (Paraffin, IF, and EM) |
Frequently Asked Questions
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