(CA) Cyfra 21-1 Lung Cancer Marker Test
Short Name: CYFRA 21-1 Test
Also known as: CYFRA 21-1, Cytokeratin 19 Fragment
(CA) Cyfra 21-1 Lung Cancer Marker Test test available at DNA Labs India for ₹3,159. Uses Electrochemiluminescence on Serum samples. Results in Reports are typically available within 1 week after sample collection.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
To measure CYFRA 21-1 levels in the blood for aiding in the diagnosis, monitoring, and prognosis of lung cancer, especially non-small cell lung cancer.
- Test Code
- 5
- Price
- ₹3,159
- Sample Type
- Serum
- Result Time
- Reports are typically available within 1 week after sample collection.
- Fasting Required
- No
- Method
- Electrochemiluminescence
Sample Collection
No specific preparation required, but provide a brief clinical history including symptoms and medical background.
Method: Venipuncture
Laboratory Analysis
A blood sample will be drawn from a vein in your arm by a trained phlebotomist.
Report Delivery
Apply pressure to the puncture site to minimize bruising; resume normal activities immediately.
Timeline: Reports are typically available within 1 week after sample collection.
Patient Instructions
About This Test
Who Should Get This Test
To measure CYFRA 21-1 levels in the blood for aiding in the diagnosis, monitoring, and prognosis of lung cancer, especially non-small cell lung cancer.
How to Prepare
- Provide a brief clinical history to the healthcare provider
- Ensure the sample is labeled correctly with patient details
- Avoid strenuous activity immediately after blood draw
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Early detection of lung cancer through markers like CYFRA 21-1 can significantly improve treatment outcomes and patient survival rates."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient sample volume (less than 0.5 mL serum)
- Hemolyzed, lipemic, or contaminated samples
- Improper labeling or missing clinical information
- Sample stored beyond stability limits
Understanding Your Results
CYFRA 21-1 levels within the reference range (<3.3 ng/mL); lung cancer is less likely, but clinical correlation is essential if symptoms persist.
Level: Normal
Levels above reference range may suggest lung cancer or other conditions like benign lung disease; further diagnostic evaluation is recommended.
Level: Elevated
Highly elevated levels often associated with advanced lung cancer; monitor treatment response and recurrence.
Level: Significantly Elevated
If you experience symptoms such as persistent cough, chest pain, or unexplained weight loss, or if test results are abnormal, consult an oncologist or chest physician for further evaluation.
Limitations
- ⚠Not diagnostic on its own; requires correlation with clinical and imaging findings
- ⚠Can be elevated in benign conditions like pneumonia or fibrosis
- ⚠May have limited sensitivity for early-stage lung cancer
- ⚠Variability between laboratories in reference ranges
Risks & Considerations
- ●Minor bruising or swelling at the needle site
- ●Rare risk of infection or fainting during blood draw
Interfering Factors
- ●Hemolyzed or lipemic blood samples
- ●Presence of other cancers or benign lung diseases
- ●Renal impairment or certain medications
- ●Improper sample collection or storage
Compare With Similar Tests
| Test | (CA) Cyfra 21-1 Lung Cancer Marker Test | CEA (Carcinoembryonic Antigen) | NSE (Neuron-Specific Enolase) | ProGRP (Pro-Gastrin-Releasing Peptide) |
|---|---|---|---|---|
| Comparison | (CA) Cyfra 21-1 Lung Cancer Marker Test | CEA is a broader tumor marker used for various cancers, while CYFRA 21-1 is more specific for lung cancer, especially non-small cell types. | NSE is often elevated in small cell lung cancer, whereas CYFRA 21-1 is primarily associated with non-small cell lung cancer. | ProGRP is a marker for small cell lung cancer, complementing CYFRA 21-1 in comprehensive lung cancer assessment. |
Frequently Asked Questions
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