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CARD14 Gene Pityriasis rubra pilaris NGS Genetic Test

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CARD14 Gene Pityriasis rubra pilaris NGS Genetic Test

Short Name: CARD14 PRP NGS Test

Also known as: CARD14 Gene Mutation Test, PRP Genetic Test, Pityriasis Rubra Pilaris Genetic Screening

CARD14 Gene Pityriasis rubra pilaris NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify mutations in the CARD14 gene associated with Pityriasis rubra pilaris (PRP), aiding in diagnosis, genetic counseling, and personalized treatment strategies.

Test Code
5111
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

No specific preparation required. Provide clinical history and undergo genetic counseling.

Method: Venipuncture or finger-prick

Step 2

Laboratory Analysis

Blood sample collected via venipuncture or saliva sample as per instructions.

Step 3

Report Delivery

Apply pressure to the puncture site. Store sample as directed.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling session to discuss implications and draw a pedigree chart.
2
During the Test:Sample collection and processing in the lab using NGS technology.
3
After the Test:Report generation and delivery; follow-up consultation advised.

About This Test

Who Should Get This Test

To identify mutations in the CARD14 gene associated with Pityriasis rubra pilaris (PRP), aiding in diagnosis, genetic counseling, and personalized treatment strategies.

How to Prepare

  • Fast for 4 hours if specified, though not required
  • Use sterile collection tubes
  • Label samples correctly
  • Transport at ambient temperature

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for CARD14 mutations is vital for confirming PRP diagnosis and can inform targeted therapies, especially in familial cases."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or finger-prick

Sample Stability

Blood: 48 hours at room temperature
Extracted DNA: Stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted blood sample
  • Insufficient sample volume
  • Contaminated or mislabeled samples

Understanding Your Results

Results indicate the presence or absence of mutations in the CARD14 gene. Positive results suggest a genetic predisposition to PRP, while negative results may not rule out other causes.
📊

Pathogenic variant detected

Confirms genetic basis for PRP; consider family screening and targeted therapy.

📊

No pathogenic variant detected

Genetic cause unlikely; explore other diagnostic avenues.

📊

Variant of uncertain significance

Further testing and clinical correlation recommended.

⚠️ When to Consult a Doctor:

Consult a dermatologist or geneticist if symptoms persist, results are positive, or for family planning advice.

Limitations

  • ⚠May not detect all genetic variants
  • ⚠Requires genetic counseling for interpretation
  • ⚠Not a standalone diagnostic tool; clinical correlation needed

Risks & Considerations

  • ●Minimal risk from blood draw (bruising, infection)
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Contaminated sample
  • ●Degraded DNA
  • ●Improper sample storage

Compare With Similar Tests

TestCARD14 Gene Pityriasis rubra pilaris NGS Genetic Test
ComparisonCARD14 Gene Pityriasis rubra pilaris NGS Genetic Test

Frequently Asked Questions

What is the CARD14 Gene PRP NGS Test?
It is a genetic test that uses Next-Generation Sequencing to identify mutations in the CARD14 gene associated with Pityriasis rubra pilaris (PRP).
Who should consider this test?
Individuals with suspected PRP, family history of PRP, unresponsive skin lesions, or those undergoing genetic counseling.
How is the test performed?
A small blood or saliva sample is collected and analyzed using NGS technology to detect CARD14 gene mutations.
What is the cost of the test?
The test costs INR 20,000, with free home sample collection available across India.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test in numerous cities across India.
What are the symptoms of PRP?
Symptoms include reddish-orange scaly patches, tiny bumps, dry skin, itching, joint pain, fever, and fatigue.
How is PRP diagnosed?
Diagnosis involves clinical evaluation by a dermatologist, skin biopsy, and genetic testing like the CARD14 NGS test.
What does a positive result mean?
A positive result indicates a mutation in the CARD14 gene, suggesting a genetic predisposition to PRP, which can guide treatment and family screening.
Are there any risks associated with the test?
Risks are minimal, primarily related to blood draw (e.g., bruising). Genetic results may have psychological implications.
Is the test covered by insurance?
Coverage varies; it is not typically covered by government schemes like PMJAY or CGHS, but private insurance may cover it depending on the policy.
How can I book the test?
You can book online through DNA Labs India's website or contact them via phone or WhatsApp for assistance.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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