CDKN1B Gene Multiple endocrine neoplasia type 4 NGS Genetic Test
Short Name: CDKN1B MEN4 NGS Test
Also known as: MEN4 Genetic Test, CDKN1B Mutation Analysis, p27 Gene Test
CDKN1B Gene Multiple endocrine neoplasia type 4 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Pasupathy Arumugam
Consultant Pathologist · Reg: 21521
Last reviewed: September 7, 2026
Overview
The purpose of this test is to detect pathogenic mutations in the CDKN1B gene to diagnose Multiple Endocrine Neoplasia Type 4 (MEN4), assess genetic risk for endocrine tumors, guide clinical management, and facilitate family planning decisions.
- Test Code
- 2907
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- No
- Method
- Next-Generation Sequencing (NGS)
Sample Collection
No specific preparation is required. Ensure to provide clinical history and family pedigree during genetic counseling.
Method: Venipuncture
Laboratory Analysis
A blood sample will be collected via venipuncture, or a drop of blood on an FTA card may be used. The process is quick and minimally invasive.
Report Delivery
Apply pressure to the puncture site to prevent bleeding. Resume normal activities unless otherwise advised.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of this test is to detect pathogenic mutations in the CDKN1B gene to diagnose Multiple Endocrine Neoplasia Type 4 (MEN4), assess genetic risk for endocrine tumors, guide clinical management, and facilitate family planning decisions.
How to Prepare
- Schedule a home collection or visit a walk-in center
- Bring identification and prescription if available
- Inform the phlebotomist of any bleeding disorders or medications
- Ensure the sample is labeled correctly and transported promptly
Doctor's Notes
Reviewed by Dr Pasupathy Arumugam — MBBS, MD (Pathology) · Reg. No. 21521
"Early genetic testing for MEN4 can lead to timely interventions and better management of endocrine tumors, improving patient outcomes."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood samples
- Insufficient sample volume
- Incorrect labeling or missing patient information
- Contaminated or degraded samples
Understanding Your Results
Positive for pathogenic variant
Confirms diagnosis of MEN4; increased risk for endocrine tumors. Recommend regular surveillance and genetic counseling for family members.
Negative for pathogenic variant
No mutations detected in CDKN1B gene; however, clinical correlation is advised if symptoms persist. Consider other genetic tests if indicated.
Variant of uncertain significance (VUS)
Genetic variant found but clinical significance is unknown. Recommend follow-up testing and consultation with a genetic specialist.
Consult a doctor or genetic counselor if you have a family history of MEN4, experience symptoms of endocrine tumors, or receive a positive or uncertain test result for further evaluation and management.
Limitations
- ⚠May not detect all genetic variants, including deep intronic mutations
- ⚠Results require interpretation by a genetic specialist
- ⚠Does not rule out other genetic causes of endocrine tumors
- ⚠Turnaround time may vary based on laboratory workload
Risks & Considerations
- ●Minor bruising or discomfort at the blood draw site
- ●Very low risk of infection or bleeding
- ●Psychological impact of genetic results; counseling is provided
Interfering Factors
- ●Poor sample quality or insufficient DNA quantity
- ●Contamination during sample collection or processing
- ●Recent blood transfusions may affect DNA analysis
- ●Technical limitations in detecting all mutation types
Frequently Asked Questions
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₹20,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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Your medical data is protected under Indian law.
✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.
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