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CFB Gene Hemolytic uremic syndrome NGS Genetic Test

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CFB Gene Hemolytic uremic syndrome NGS Genetic Test

Short Name: CFB Gene HUS NGS Test

Also known as: CFB Gene HUS Test, Complement Factor B Gene Test, Atypical HUS Genetic Test

CFB Gene Hemolytic uremic syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of the CFB Gene Hemolytic Uremic Syndrome NGS Genetic Test is to diagnose mutations in the CFB gene that cause atypical Hemolytic Uremic Syndrome, a condition leading to kidney failure. It helps in confirming the genetic basis of the disease, guiding treatment decisions, and assessing family risk.

Test Code
5410
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

No specific preparation required. Inform the lab about any medications or recent transfusions.

Method: Venipuncture

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in the arm using a sterile needle. For FTA card, a finger prick may be used.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bleeding. Resume normal activities immediately.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling session recommended to understand test implications and draw a family pedigree chart.
2
During the Test:Sample collection via blood draw or FTA card; procedure takes about 10-15 minutes.
3
After the Test:Results are analyzed in the lab; report delivered in 3-4 weeks. Follow-up counseling advised.

About This Test

Who Should Get This Test

The purpose of the CFB Gene Hemolytic Uremic Syndrome NGS Genetic Test is to diagnose mutations in the CFB gene that cause atypical Hemolytic Uremic Syndrome, a condition leading to kidney failure. It helps in confirming the genetic basis of the disease, guiding treatment decisions, and assessing family risk.

How to Prepare

  • Ensure the patient is relaxed and hydrated.
  • Use aseptic technique for blood collection.
  • Label the sample correctly with patient details.
  • Store the sample at ambient temperature if using FTA card.
  • Transport the sample to the lab within 24 hours.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for CFB gene mutations is essential for diagnosing atypical Hemolytic Uremic Syndrome and guiding personalized treatment. Consult a genetic counselor or nephrologist for comprehensive care."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 mL blood
ContainerEDTA tube or FTA card
Collection MethodVenipuncture

Sample Stability

Blood samples: Stable for 48 hours at 2-8°C
FTA card samples: Stable at room temperature for up to 1 month
Extracted DNA: Stable at -20°C for long-term storage
Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Insufficient sample volume
  • Incorrect labeling or missing patient information
  • Contaminated samples

Understanding Your Results

Results from the CFB Gene NGS Genetic Test indicate the presence or absence of mutations in the CFB gene. A positive result confirms a genetic predisposition to atypical HUS, while a negative result suggests no pathogenic variants in the analyzed regions.
Positive result: Pathogenic variant detected; recommend genetic counseling and clinical evaluation.
Negative result: No pathogenic variants; consider other genetic or environmental factors.
Variant of uncertain significance (VUS): Further testing or family studies may be needed.
Results should be correlated with clinical symptoms and family history.
⚠️ When to Consult a Doctor:

Consult a doctor immediately if you experience symptoms like bloody diarrhea, reduced urine output, or swelling. After testing, consult a genetic counselor or nephrologist to discuss results and management options.

Limitations

  • ⚠May not detect all genetic variants or novel mutations
  • ⚠Requires genetic counseling for interpretation
  • ⚠Results do not guarantee disease onset due to variable penetrance
  • ⚠Limited to CFB gene analysis; other genes involved in HUS are not covered

Risks & Considerations

  • ●Minimal physical risks from blood draw, such as bruising or infection
  • ●Psychological stress from test results
  • ●Potential for uncertain results requiring further investigation

Interfering Factors

  • ●Poor sample quality or contamination
  • ●Recent blood transfusions affecting DNA integrity
  • ●Inadequate sample volume or improper storage

Compare With Similar Tests

TestCFB Gene Hemolytic uremic syndrome NGS Genetic TestComplement Factor H Gene TestADAMTS13 Activity TestShiga Toxin Test
ComparisonCFB Gene Hemolytic uremic syndrome NGS Genetic Test

Frequently Asked Questions

What is the CFB Gene Hemolytic Uremic Syndrome NGS Genetic Test?
It is a genetic test that uses Next-Generation Sequencing to detect mutations in the CFB gene, which can cause atypical Hemolytic Uremic Syndrome, a rare kidney disorder.
How much does the test cost?
The test costs INR 20,000 at DNA Labs India, with free home sample collection available across India.
What are the symptoms of CFB gene-related HUS?
Symptoms include abdominal pain, bloody diarrhea, fever, vomiting, weakness, fatigue, swelling in arms or legs, decreased urine output, and high blood pressure.
How is the test performed?
A blood sample or extracted DNA is collected and analyzed using NGS technology to sequence the CFB gene for mutations.
What is the turnaround time for results?
Results are typically available within 3 to 4 weeks after sample collection.
Is fasting required before the test?
No, fasting is not required for this genetic test.
Who should consider this test?
Individuals with symptoms of HUS, a family history of atypical HUS, or unexplained kidney issues should consider this test.
What does a positive result mean?
A positive result indicates a pathogenic mutation in the CFB gene, confirming a genetic predisposition to atypical HUS. Genetic counseling is recommended.
Can the test detect all causes of HUS?
No, this test specifically targets the CFB gene. Other genetic or infectious causes may require different tests.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test in numerous cities across India.
What should I do after receiving the results?
Consult a genetic counselor or nephrologist to discuss the results, understand implications, and plan management or treatment.
Are there any risks associated with the test?
The test involves minimal physical risks from blood draw, but there may be psychological stress from results. Genetic counseling can help address concerns.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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