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CFHR2 Gene Hemolytic uremic syndrome NGS Genetic Test

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CFHR2 Gene Hemolytic uremic syndrome NGS Genetic Test

Also known as: CFHR2 Gene HUS Test, Hemolytic Uremic Syndrome Genetic Test

CFHR2 Gene Hemolytic uremic syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To identify mutations or variants in the CFHR2 gene that may cause or increase the risk of Hemolytic Uremic Syndrome (HUS), facilitating early diagnosis, genetic counseling, and informed management strategies.

Test Code
5413
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Genetic counseling session to discuss test implications, clinical history review, and informed consent.

Method: Venipuncture

Step 2

Laboratory Analysis

Blood sample collection via venipuncture or use of FTA card for one drop of blood.

Step 3

Report Delivery

Sample is transported to the laboratory under ambient conditions for NGS analysis.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Schedule a genetic counseling session to understand the test, its implications, and provide informed consent.
2
During the Test:A blood sample will be collected from a vein in your arm or via a finger prick for FTA card.
3
After the Test:Wait for the report, which will be delivered in 3-4 weeks via online portal, email, or WhatsApp.

About This Test

Who Should Get This Test

To identify mutations or variants in the CFHR2 gene that may cause or increase the risk of Hemolytic Uremic Syndrome (HUS), facilitating early diagnosis, genetic counseling, and informed management strategies.

How to Prepare

  • Provide detailed clinical and family history
  • Ensure proper sample labeling and handling
  • No specific fasting required unless advised by physician

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Consult a nephrologist for HUS management and genetic counseling to understand test implications."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture

Sample Stability

Blood samples: Stable at room temperature for up to 48 hours
Extracted DNA: Stable at -20°C for long-term storage
Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Insufficient sample volume
  • Incorrect sample labeling or documentation

Understanding Your Results

Results indicate the presence or absence of mutations in the CFHR2 gene, which may be associated with Hemolytic Uremic Syndrome.
Positive Result: Pathogenic or likely pathogenic variant detected, indicating increased risk for HUS. Consult a nephrologist or genetic counselor for management.
Negative Result: No pathogenic variants detected in the CFHR2 gene. However, HUS may still occur due to other genetic or environmental factors.
Variant of Uncertain Significance (VUS): A genetic variant with unknown clinical significance. Further testing or family studies may be recommended.
Inconclusive Result: Technical issues or insufficient DNA. Repeat testing may be necessary.
⚠️ When to Consult a Doctor:

If symptoms of HUS such as abdominal pain, bloody diarrhea, low urine output, or jaundice are present, or if there is a family history of HUS or kidney disorders.

Limitations

  • ⚠May not detect all genetic causes of HUS, as other genes can be involved
  • ⚠Results require interpretation by a genetic specialist
  • ⚠Does not replace clinical diagnosis or other laboratory tests

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Psychological impact of genetic results on patient and family
  • ●Potential for insurance or discrimination issues based on genetic information

Interfering Factors

  • ●Degraded or insufficient DNA sample quality
  • ●Contamination during sample collection or processing
  • ●Technical limitations of NGS in detecting all variant types

Frequently Asked Questions

What is the CFHR2 gene?
The CFHR2 gene encodes a protein involved in regulating the complement system, which is part of the immune response. Mutations in this gene can contribute to Hemolytic Uremic Syndrome.
What is Hemolytic Uremic Syndrome (HUS)?
HUS is a rare condition characterized by destruction of red blood cells, low platelet count, and kidney damage, often leading to acute kidney failure.
Who should consider this genetic test?
Individuals with a family history of HUS, symptoms like abdominal pain or bloody diarrhea, or unexplained kidney issues should consider this test.
How is the CFHR2 Gene HUS NGS Test performed?
The test uses Next-Generation Sequencing (NGS) to analyze DNA from a blood sample for mutations in the CFHR2 gene.
What is the cost of the test in India?
The cost is INR 20000, which includes home sample collection in many cities across India.
Is fasting required before the test?
No, fasting is not required for this genetic test.
How long does it take to get the results?
Results are typically available in 3 to 4 weeks and can be accessed online, via email, or WhatsApp.
What do the test results mean?
Results indicate if pathogenic variants are detected in the CFHR2 gene, which may increase the risk for HUS. Interpretation should be done by a genetic specialist.
Is home sample collection available?
Yes, free home sample collection is available for online bookings in numerous cities across India.
What are the symptoms of HUS?
Symptoms include abdominal pain, bloody diarrhea, fever, fatigue, low urine output, jaundice, and bruising.
Can this test diagnose HUS?
This test identifies genetic mutations associated with HUS but should be used alongside clinical evaluation and other diagnostic tests for a complete diagnosis.
Who should I consult after getting the results?
Consult a nephrologist, hematologist, or genetic counselor to understand the implications and discuss management options.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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