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CFHR4 Gene Hemolytic uremic syndrome NGS Genetic Test

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CFHR4 Gene Hemolytic uremic syndrome NGS Genetic Test

Short Name: CFHR4 HUS NGS Test

Also known as: CFHR4 Gene Test, HUS Genetic Test, Complement Factor H-Related 4 Gene Test

CFHR4 Gene Hemolytic uremic syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify mutations in the CFHR4 gene associated with Hemolytic Uremic Syndrome (HUS), aiding in diagnosis, treatment planning, and genetic counseling.

Test Code
5415
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Clinical history review and genetic counseling session recommended. No fasting required.

Method: Venipuncture or FTA Card Spot

Step 2

Laboratory Analysis

Blood sample collected via venipuncture into EDTA tube or one drop on FTA card by trained phlebotomist.

Step 3

Report Delivery

Sample labeled and transported to lab under ambient conditions for DNA extraction and NGS analysis.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Schedule a genetic counseling session to discuss family history and test implications.
2
During the Test:Blood sample collection takes about 10-15 minutes; minimal discomfort.
3
After the Test:Resume normal activities; await results in 3-4 weeks and follow up with genetic counselor.

About This Test

Who Should Get This Test

To identify mutations in the CFHR4 gene associated with Hemolytic Uremic Syndrome (HUS), aiding in diagnosis, treatment planning, and genetic counseling.

How to Prepare

  • Ensure proper identification and consent
  • Avoid hemolysis during blood draw
  • Store FTA card at room temperature

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic testing for CFHR4 mutations can guide targeted therapy in atypical HUS, improving patient outcomes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume3-5 mL Blood or as per FTA Card
ContainerEDTA Tube or FTA Card
Collection MethodVenipuncture or FTA Card Spot

Sample Stability

Blood in EDTA: Stable at 2-8°C for 72 hours
FTA Card: Stable at room temperature for up to 30 days
Sample Rejection Criteria:
  • Hemolyzed or clotted sample
  • Insufficient sample volume
  • Incorrect labeling or missing consent

Understanding Your Results

Results indicate the presence or absence of mutations in the CFHR4 gene linked to Hemolytic Uremic Syndrome.
📊

No pathogenic variant detected

Low genetic risk for HUS; consider other causes if symptoms persist.

📊

Pathogenic variant detected

High genetic risk for atypical HUS; recommend clinical evaluation and family screening.

📊

Variant of uncertain significance

Further testing or family studies may be needed for clarification.

⚠️ When to Consult a Doctor:

If symptoms of HUS are present, family history of HUS, or if genetic test results are positive or uncertain.

Limitations

  • ⚠May not detect all genetic variants or deep intronic mutations
  • ⚠Requires genetic counseling for interpretation
  • ⚠Not a standalone diagnostic; clinical correlation needed

Risks & Considerations

  • ●Minor bruising or pain at blood draw site
  • ●Very low risk of infection
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Contaminated or degraded DNA sample
  • ●Improper sample storage or handling
  • ●Recent blood transfusion

Compare With Similar Tests

TestCFHR4 Gene Hemolytic uremic syndrome NGS Genetic TestStool Culture for E. coliComplete Blood Count (CBC)Serum Creatinine TestComplement Factor H Test
ComparisonCFHR4 Gene Hemolytic uremic syndrome NGS Genetic TestDetects bacterial infection but not genetic causes.Assesses anemia and thrombocytopenia but not specific gene mutations.Evaluates kidney function but does not identify genetic etiology.Tests for other complement genes; CFHR4 is specific for this panel.

Frequently Asked Questions

What is the CFHR4 Gene HUS NGS Genetic Test?
It is a genetic test that uses Next-Generation Sequencing to detect mutations in the CFHR4 gene associated with Hemolytic Uremic Syndrome.
Who should consider this test?
Individuals with symptoms of HUS, family history of HUS, or those diagnosed with atypical HUS.
How is the test performed?
A blood sample or DNA extract is analyzed using NGS technology to identify CFHR4 gene mutations.
What is the cost of the test?
The test costs INR 20000, with home sample collection available at no extra charge.
Is home sample collection available?
Yes, free home collection is offered in many cities across India.
How long does it take to get results?
Results are typically available in 3 to 4 weeks.
What do the results mean?
Results indicate if a pathogenic CFHR4 mutation is present, which can confirm genetic HUS risk.
Are there any risks associated with the test?
Risks are minimal, such as bruising from blood draw; genetic counseling helps address psychological concerns.
How accurate is the NGS technology?
NGS is highly accurate for detecting gene mutations, but no test is 100% infallible.
Can this test diagnose all types of HUS?
No, it specifically detects genetic mutations in CFHR4; other causes like infection require different tests.
What should I do if the test is positive?
Consult a nephrologist or geneticist for further evaluation and treatment options.
Is genetic counseling necessary?
Yes, it is recommended to understand test implications, family risks, and next steps.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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