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CFHR5 Gene Hemolytic uremic syndrome NGS Genetic Test

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CFHR5 Gene Hemolytic uremic syndrome NGS Genetic Test

Also known as: CFHR5 Gene HUS Test, Hemolytic Uremic Syndrome Genetic Test

CFHR5 Gene Hemolytic uremic syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood, Extracted DNA, FTA Card samples. Results in 3-4 weeks. Free home collection in 300+ cities across India.

Next-Generation Sequencing (NGS)All Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

To diagnose genetic mutations in the CFHR5 gene that cause atypical Hemolytic Uremic Syndrome (HUS), enabling targeted treatment and family screening.

Test Code
5416
Price
₹20,000
Sample Type
Blood, Extracted DNA, FTA Card
Result Time
3-4 weeks
Fasting Required
Yes
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Provide clinical history and undergo genetic counseling. Fast if required.

Method: Venipuncture or Saliva Collection

Step 2

Laboratory Analysis

Blood sample drawn via venipuncture or saliva collected.

Step 3

Report Delivery

Sample sent to laboratory for NGS analysis.

Timeline: 3-4 weeks

Patient Instructions

1
Before the Test:Genetic counseling session and clinical history review.
2
During the Test:Sample collection and processing in the laboratory.
3
After the Test:Report generation, genetic counseling for result interpretation.

About This Test

Who Should Get This Test

To diagnose genetic mutations in the CFHR5 gene that cause atypical Hemolytic Uremic Syndrome (HUS), enabling targeted treatment and family screening.

How to Prepare

  • Fast for 8-12 hours if required
  • Bring valid ID and doctor's prescription
  • Avoid strenuous activity before sample collection

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Genetic testing for CFHR5 mutations is crucial for diagnosing atypical HUS and guiding treatment decisions, especially in patients with family history or unexplained kidney issues."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood, Extracted DNA, FTA Card
Collection MethodVenipuncture or Saliva Collection

Sample Stability

Blood: 24 hours at room temperature
Extracted DNA: stable for several days at 4°C
Sample Rejection Criteria:
  • Hemolyzed or clotted sample
  • Insufficient sample volume
  • Improperly labeled sample

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the CFHR5 gene associated with Hemolytic Uremic Syndrome.
Positive for pathogenic variant: Indicates genetic cause of HUS, requiring specialist management.
Negative for pathogenic variant: No CFHR5 mutations detected; consider other genetic or non-genetic causes.
Variant of uncertain significance: Further testing and family studies may be needed.
⚠️ When to Consult a Doctor:

If symptoms persist, family history of HUS, or after receiving positive test results, consult a nephrologist or geneticist.

Limitations

  • ⚠May not detect all genetic variants
  • ⚠Requires genetic counseling for interpretation
  • ⚠Results may have variants of uncertain significance

Risks & Considerations

  • ●Minimal risk from blood draw (bruising, infection)
  • ●Psychological impact of genetic results
  • ●Potential for uncertain findings

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Hemolyzed blood sample

Compare With Similar Tests

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ComparisonCFHR5 Gene Hemolytic uremic syndrome NGS Genetic Test

Frequently Asked Questions

What is the CFHR5 Gene Hemolytic Uremic Syndrome NGS Genetic Test?
It is a genetic test that uses Next-Generation Sequencing to detect mutations in the CFHR5 gene associated with atypical Hemolytic Uremic Syndrome (HUS).
Why is this test recommended?
It is recommended for individuals with symptoms of HUS, such as hematuria, anemia, and kidney failure, or with a family history of the condition, to identify genetic causes.
What are the symptoms of CFHR5-related HUS?
Symptoms include blood in urine, abdominal pain, diarrhea, fever, anemia, and kidney failure.
How is the test performed?
The test analyzes DNA from a blood or saliva sample using NGS technology to identify mutations in the CFHR5 gene.
What sample is required for the test?
A blood sample, extracted DNA, or one drop of blood on an FTA card is required.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What is the cost of the test?
The cost is INR 20,000, which includes the test, genetic counseling, and support.
Is the test covered by insurance?
This test may not be covered by insurance; it is recommended to check with your provider before scheduling.
What do the results mean?
Results can indicate positive for pathogenic variant, negative, or variant of uncertain significance, guiding diagnosis and treatment.
Are there any risks associated with the test?
Risks are minimal, such as bruising from blood draw, but psychological impact of results should be considered.
How can I prepare for the test?
Provide clinical history, undergo genetic counseling, and fast if required. Bring ID and prescription.
What should I do after receiving the results?
Consult a nephrologist or geneticist for interpretation and management, especially if positive or uncertain.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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