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chr. 11p15 Gene Silver-Russell syndrome NGS Genetic Test

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chr. 11p15 Gene Silver-Russell syndrome NGS Genetic Test

Short Name: Silver-Russell Syndrome NGS Test

Also known as: SRS Genetic Test, chr. 11p15 Gene Analysis, Silver-Russell Syndrome DNA Test

chr. 11p15 Gene Silver-Russell syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

PediatricsPediatric🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr Pasupathy Arumugam

Dr Pasupathy Arumugam

Consultant Pathologist · Reg: 21521

Last reviewed: September 7, 2026

Overview

The purpose of this test is to identify genetic mutations in the chr. 11p15 gene that cause Silver-Russell syndrome, enabling accurate diagnosis and informed management for affected individuals.

Test Code
2822
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation required. Ensure genetic counseling is scheduled to discuss test implications and family history.

Method: Venipuncture or Saliva Collection

Step 2

Laboratory Analysis

A trained phlebotomist will collect a blood sample via venipuncture or a saliva sample using a collection kit.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bleeding. Resume normal activities immediately.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Schedule a genetic counseling session to discuss the test, implications, and family history.
2
During the Test:The test involves analyzing DNA from a blood or saliva sample using Next-generation sequencing (NGS) technology to detect mutations in the chr. 11p15 gene.
3
After the Test:Results will be available in 3-4 weeks. Follow up with your doctor for interpretation and next steps.

About This Test

Who Should Get This Test

The purpose of this test is to identify genetic mutations in the chr. 11p15 gene that cause Silver-Russell syndrome, enabling accurate diagnosis and informed management for affected individuals.

How to Prepare

  • Bring identification and prescription
  • Inform about any medications or health conditions
  • Follow instructions for saliva collection if applicable

Doctor's Notes

Reviewed by — MBBS, MD (Pathology) · Reg. No. 21521

"Early diagnosis through genetic testing is crucial for managing Silver-Russell syndrome and improving patient outcomes."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture or Saliva Collection

Sample Stability

Sample Rejection Criteria:
  • Hemolyzed sample
  • Insufficient volume
  • Incorrect labeling
  • Contaminated sample

Understanding Your Results

Results indicate whether pathogenic variants in the chr. 11p15 gene are detected, which are associated with Silver-Russell syndrome.
📊

Normal

No pathogenic variants detected. Clinical correlation recommended if symptoms persist.

📊

Abnormal

Pathogenic variant detected. Consistent with Silver-Russell syndrome. Genetic counseling and further management advised.

⚠️ When to Consult a Doctor:

If results are abnormal or if clinical symptoms of Silver-Russell syndrome persist, consult a geneticist or pediatrician for further evaluation and management.

Limitations

  • ⚠May not detect all types of genetic variants
  • ⚠Results require clinical correlation
  • ⚠False negatives or positives possible
  • ⚠Does not rule out other genetic disorders

Risks & Considerations

  • ●Minimal physical risk from blood draw
  • ●Potential psychological impact of results
  • ●Risk of incidental findings

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Incorrect sample handling

Frequently Asked Questions

What is Silver-Russell syndrome?
Silver-Russell syndrome is a rare genetic disorder characterized by growth failure, both before and after birth, and distinctive physical features such as a triangular face and curved fifth finger.
What causes Silver-Russell syndrome?
It is often caused by genetic changes, including deletions or duplications in the chr. 11p15 gene, which regulates growth and development.
How is Silver-Russell syndrome diagnosed?
Diagnosis involves clinical evaluation and genetic testing, such as NGS analysis of the chr. 11p15 gene, to confirm genetic mutations.
What is the chr. 11p15 gene?
The chr. 11p15 gene is a region on chromosome 11 involved in regulating growth; mutations here can lead to Silver-Russell syndrome.
What is NGS genetic testing?
Next-generation sequencing (NGS) is a advanced genetic testing method that analyzes multiple genes simultaneously to detect mutations associated with disorders like Silver-Russell syndrome.
How accurate is this test?
NGS genetic testing is highly accurate for detecting pathogenic variants in the chr. 11p15 gene, but results should be correlated with clinical findings.
What are the symptoms of Silver-Russell syndrome?
Common symptoms include low birth weight, poor growth, small head size, triangular face, curved spine, clinodactyly, prominent forehead, and delayed motor development.
Is this test painful?
The test involves a blood draw or saliva collection, which may cause minimal discomfort, but it is generally non-invasive and safe.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What if the test is positive?
A positive result indicates a pathogenic variant in the chr. 11p15 gene, confirming Silver-Russell syndrome. Genetic counseling and management plans should be discussed with a healthcare provider.
Can this test be done during pregnancy?
This test is typically for postnatal diagnosis. For prenatal testing, consult a genetic counselor for appropriate options like amniocentesis or CVS.
Is home collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across India, including major cities.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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