Skip to main content
DNA Labs India

CHRM3 Gene Prune belly syndrome NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

CHRM3 Gene Prune belly syndrome NGS Genetic Test

Short Name: CHRM3 PBS NGS Test

Also known as: Eagle-Barrett Syndrome, Triad Syndrome

CHRM3 Gene Prune belly syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic TestMalePediatric🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to diagnose Prune Belly Syndrome by identifying mutations in the CHRM3 gene, aiding in early intervention, treatment planning, and genetic counseling for affected individuals and families.

Test Code
2785
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation is required. Ensure the patient's clinical history and family pedigree are documented for genetic counseling.

Method: Venipuncture or finger-prick

Step 2

Laboratory Analysis

A blood sample will be collected via venipuncture or a finger-prick for FTA card. The process is quick and minimally invasive.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bleeding. Store the sample as instructed and transport to the lab promptly.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Provide clinical history and undergo genetic counseling. No fasting required.
2
During the Test:Blood sample collection via venipuncture or finger-prick. Procedure takes about 10-15 minutes.
3
After the Test:Resume normal activities. Monitor the puncture site for any discomfort.

About This Test

Who Should Get This Test

The purpose of this test is to diagnose Prune Belly Syndrome by identifying mutations in the CHRM3 gene, aiding in early intervention, treatment planning, and genetic counseling for affected individuals and families.

How to Prepare

  • Use sterile equipment for sample collection
  • Label the sample correctly with patient details
  • For blood on FTA card, ensure one drop is applied and dried properly
  • Maintain sample integrity during transport

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This test is essential for early diagnosis and management of Prune Belly Syndrome, allowing for timely intervention and genetic counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required for NGS analysis
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or finger-prick

Sample Stability

Blood: Stable for 24 hours at room temperature
Extracted DNA: Stable for years if stored at -20°C
FTA card: Stable for months at room temperature
Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Insufficient sample volume
  • Improperly labeled or contaminated samples
  • Samples older than stability period

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the CHRM3 gene. A positive result confirms a genetic basis for Prune Belly Syndrome, while a negative result may require further testing.
📊

Pathogenic variant detected

Confirms diagnosis of Prune Belly Syndrome due to CHRM3 mutation. Genetic counseling recommended.

📊

Variant of uncertain significance

Further clinical correlation and family studies needed.

📊

No pathogenic variant detected

Does not rule out PBS; consider other genetic or non-genetic causes.

📊

Carrier status

Individual carries one mutated copy; may not show symptoms but can pass to offspring.

⚠️ When to Consult a Doctor:

Consult a doctor if the test results are positive, if there are symptoms of Prune Belly Syndrome, or for genetic counseling and family planning.

Limitations

  • ⚠May not detect all genetic variants or mutations in the CHRM3 gene
  • ⚠Results require interpretation by a qualified geneticist
  • ⚠Does not rule out other genetic causes of Prune Belly Syndrome
  • ⚠Limited to known mutations in the CHRM3 gene based on current databases

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Psychological impact of genetic results; counseling available

Interfering Factors

  • ●Sample contamination during collection or handling
  • ●Degraded DNA due to improper storage
  • ●Hemolyzed or lipemic blood samples
  • ●Recent blood transfusions may affect DNA analysis

Frequently Asked Questions

What is the CHRM3 Gene Prune Belly Syndrome NGS Genetic Test?
It is a genetic test that uses next-generation sequencing to detect mutations in the CHRM3 gene associated with Prune Belly Syndrome.
Who should take this test?
Individuals with suspected Prune Belly Syndrome, family history of the disorder, or related symptoms like undescended testicles or urinary abnormalities.
What is the cost of the test?
The test costs INR 20,000, with home sample collection available across India.
How is the sample collected?
A blood sample is collected via venipuncture or a finger-prick for FTA card at home or in a lab.
Is fasting required before the test?
No, fasting is not required for this genetic test.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What does a positive result mean?
A positive result indicates a mutation in the CHRM3 gene, confirming a genetic cause for Prune Belly Syndrome. Genetic counseling is recommended.
Can this test detect all cases of Prune Belly Syndrome?
No, it specifically detects CHRM3 gene mutations. Other genetic or non-genetic causes may require additional testing.
Is the test accurate?
Yes, NGS technology provides high accuracy, but results should be interpreted by a qualified geneticist.
What are the risks of the test?
Risks are minimal, such as bruising from blood draw. Psychological support is available for result interpretation.
Do I need a doctor's referral for this test?
A referral is recommended for proper clinical correlation, but you can book directly through DNA Labs India.
Is home sample collection available?
Yes, free home sample collection is available for online bookings across many cities in India.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

Related Tests

Amino Acids Qualitative Two Dimensional Urine Test

₹1,439

Succinylacetone Urine Test

₹5,000

RXFP2 Gene Cryptorchidism NGS Genetic Test

₹20,000

EFNB1 Gene Craniofrontonasal syndrome NGS Genetic Test

₹20,000

MNX1 Gene Currarino syndrome NGS Genetic Test

₹20,000

FGFR1 Gene Craniosynostosis, FGFR1 related NGS Genetic Test

₹20,000
For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

Book Your Test

Enter your details and we'll connect you within 15 minutes.

🧬

Quick Connect

Enter your mobile number and we’ll connect you with the team.

+91

✅ Connecting you now...

🔒 Your number is used to respond to this request.