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CHST8 Gene Peeling skin syndrome type 3 NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

CHST8 Gene Peeling skin syndrome type 3 NGS Genetic Test

Short Name: CHST8 PSS3 NGS Test

Also known as: PSS3, Peeling Skin Syndrome Type 3, CHST8-related PSS

CHST8 Gene Peeling skin syndrome type 3 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks from sample receipt. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To detect mutations in the CHST8 gene for the diagnosis of Peeling Skin Syndrome Type 3.

Test Code
5106
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks from sample receipt
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

Genetic counseling is recommended before testing. Provide clinical history and family pedigree.

Method: Venipuncture or FTA Card collection

Step 2

Laboratory Analysis

A blood sample is collected via venipuncture or using an FTA card.

Step 3

Report Delivery

Sample is transported to the laboratory under appropriate conditions for analysis.

Timeline: 3 to 4 weeks from sample receipt

Patient Instructions

1
Before the Test:Schedule a genetic counseling session to discuss the test, implications, and family history.
2
During the Test:The test involves a simple blood draw, which takes a few minutes.
3
After the Test:Results will be available in 3 to 4 weeks. Follow up with your healthcare provider for interpretation.

About This Test

Who Should Get This Test

To detect mutations in the CHST8 gene for the diagnosis of Peeling Skin Syndrome Type 3.

How to Prepare

  • No fasting required
  • Bring valid ID and doctor's prescription
  • Ensure sample is properly labeled

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for CHST8 mutations is crucial for confirming Peeling Skin Syndrome Type 3 and guiding treatment strategies."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required
Collection MethodVenipuncture or FTA Card collection

Sample Stability

Blood sample stable at room temperature for up to 24 hours
FTA card samples stable for longer periods
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Insufficient sample volume
  • Improperly labeled samples

Understanding Your Results

The test results indicate whether pathogenic mutations in the CHST8 gene are present.
📊

Positive for pathogenic variant

Confirms diagnosis of Peeling Skin Syndrome Type 3. Genetic counseling advised.

📊

Negative for pathogenic variant

No mutations detected in CHST8 gene. Clinical correlation recommended.

📊

Variant of uncertain significance

Further testing or family studies may be required.

⚠️ When to Consult a Doctor:

Consult a dermatologist or geneticist if you experience persistent skin peeling, blisters, or other symptoms suggestive of PSS3.

Limitations

  • ⚠May not detect all types of mutations
  • ⚠Results require clinical correlation
  • ⚠Does not rule out other genetic disorders

Risks & Considerations

  • ●Minimal risk from blood draw: bruising, infection
  • ●Psychological impact of genetic results
  • ●Potential for genetic discrimination

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Technical errors in sequencing

Compare With Similar Tests

TestCHST8 Gene Peeling skin syndrome type 3 NGS Genetic TestSanger SequencingWhole Exome Sequencing
ComparisonCHST8 Gene Peeling skin syndrome type 3 NGS Genetic Test

Frequently Asked Questions

What is Peeling Skin Syndrome Type 3?
Peeling Skin Syndrome Type 3 (PSS3) is a rare genetic disorder that causes recurrent skin peeling due to mutations in the CHST8 gene.
How is PSS3 inherited?
PSS3 is inherited in an autosomal recessive pattern, meaning both parents must carry a mutated gene for the child to be affected.
What are the symptoms of PSS3?
Symptoms include recurrent skin peeling on hands and feet, redness, blisters, itching, pain, nail dystrophy, hair loss, and oral involvement.
How is PSS3 diagnosed?
Diagnosis is based on clinical presentation, family history, and genetic testing such as the CHST8 Gene NGS Genetic Test.
What is the CHST8 gene?
The CHST8 gene provides instructions for making an enzyme involved in skin cell adhesion; mutations lead to PSS3.
What is NGS genetic testing?
Next Generation Sequencing (NGS) is a high-throughput method that sequences multiple genes simultaneously to detect mutations accurately.
How accurate is the CHST8 gene test?
The NGS Genetic Test is highly accurate for identifying mutations in the CHST8 gene, confirming PSS3 diagnosis.
What is the cost of the test?
The CHST8 Gene Peeling Skin Syndrome Type 3 NGS Genetic Test costs INR 20000 at DNA Labs India.
Is home collection available?
Yes, free home sample collection is available for online bookings across many cities in India.
How long does it take to get results?
Results are typically available in 3 to 4 weeks from sample receipt.
What should I do if the test is positive?
If positive, consult a dermatologist or geneticist for management and genetic counseling for family planning.
Can PSS3 be treated?
There is no cure for PSS3, but symptoms can be managed with moisturizers, avoiding triggers, and supportive care.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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