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CLCF1 Gene Cold-induced sweating syndrome type 2 NGS Genetic Test

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CLCF1 Gene Cold-induced sweating syndrome type 2 NGS Genetic Test

Short Name: CLCF1 Gene CISS2 NGS Test

Also known as: CISS2, Cold-induced sweating syndrome type 2

CLCF1 Gene Cold-induced sweating syndrome type 2 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Results are typically available within 2 weeks after sample receipt.. Free home collection in 300+ cities across India.

PediatricsPediatric🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to detect mutations in the CLCF1 gene to confirm a diagnosis of Cold-induced sweating syndrome type 2 (CISS2), enabling appropriate medical management, genetic counseling, and family planning guidance.

Test Code
5725
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Results are typically available within 2 weeks after sample receipt.
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation is required. Provide clinical history and undergo genetic counseling as recommended.

Method: Cheek swab or venipuncture

Step 2

Laboratory Analysis

A cheek swab or blood sample will be collected by a trained professional. The process is quick and minimally invasive.

Step 3

Report Delivery

Apply pressure to the puncture site if blood is drawn. Resume normal activities immediately.

Timeline: Results are typically available within 2 weeks after sample receipt.

Patient Instructions

1
Before the Test:Understand the test purpose, provide informed consent, and share family medical history during genetic counseling.
2
During the Test:Sample collection takes a few minutes. No special procedures are required during the test.
3
After the Test:Wait for results as per the turnaround time. Genetic counseling will be provided to discuss findings.

About This Test

Who Should Get This Test

The purpose of this test is to detect mutations in the CLCF1 gene to confirm a diagnosis of Cold-induced sweating syndrome type 2 (CISS2), enabling appropriate medical management, genetic counseling, and family planning guidance.

How to Prepare

  • Ensure the mouth is clean before cheek swab collection
  • For blood sample, avoid eating or drinking for 30 minutes prior if specified
  • Follow all instructions provided by the collection team

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic testing for CISS2 is crucial for timely intervention and management, especially in pediatric cases with suspected genetic disorders."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume2-5 mL for blood
ContainerEDTA tube or FTA card
Collection MethodCheek swab or venipuncture

Sample Stability

Blood sample stable for 48 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted blood sample
  • Insufficient sample volume
  • Incorrectly labeled or unlabeled samples

Understanding Your Results

Results indicate the presence or absence of mutations in the CLCF1 gene. A positive result confirms CISS2, while a negative result may require further clinical evaluation.
Positive: Pathogenic mutation detected, consistent with CISS2 diagnosis
Negative: No pathogenic variants found, but clinical correlation is advised
Variant of uncertain significance: Further testing or family studies may be needed
⚠️ When to Consult a Doctor:

Consult a geneticist or specialist if symptoms persist, worsen, or if there is a family history of similar conditions.

Limitations

  • ⚠May not detect all possible mutations in the CLCF1 gene
  • ⚠Results require interpretation by a genetic counselor or specialist
  • ⚠Does not rule out other genetic conditions with similar symptoms

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or discomfort
  • ●Cheek swab is non-invasive with no significant risks

Interfering Factors

  • ●Contaminated or degraded DNA sample
  • ●Improper sample storage or handling
  • ●Recent blood transfusion may affect results

Compare With Similar Tests

TestCLCF1 Gene Cold-induced sweating syndrome type 2 NGS Genetic TestNTRK1 Gene Congenital insensitivity to pain with anhidrosis NGS TestSCN9A Gene Erythromelalgia NGS Test
ComparisonCLCF1 Gene Cold-induced sweating syndrome type 2 NGS Genetic Test

Frequently Asked Questions

What is Cold-induced sweating syndrome type 2 (CISS2)?
CISS2 is a rare genetic disorder characterized by profuse sweating and fever-like symptoms triggered by cold exposure, caused by mutations in the CLCF1 gene.
What causes CISS2?
CISS2 is caused by mutations in the CLCF1 gene, which is involved in temperature regulation in the body.
How is the CLCF1 gene test performed?
The test uses next-generation sequencing (NGS) to analyze DNA from a cheek swab or blood sample for mutations in the CLCF1 gene.
What are the symptoms of CISS2?
Symptoms include profuse sweating in cold, fever-like episodes, abnormalities in teeth and nails, developmental delays, and seizures.
Who should get this test?
Individuals with symptoms of CISS2, a family history of the disorder, or those suspected of having a genetic condition based on clinical evaluation.
How long does it take to get results?
Results are typically available within 2 weeks after sample collection.
Is the test painful?
The test involves a cheek swab or blood draw, which may cause minimal discomfort but is generally not painful.
What if the test is positive?
A positive result confirms CISS2, and genetic counseling will be provided to discuss management options and family implications.
Can CISS2 be treated?
There is no cure, but symptoms can be managed with supportive care, and early diagnosis helps in planning appropriate interventions.
Is genetic counseling included?
Yes, DNA Labs India provides genetic counseling to help interpret results and guide next steps.
How accurate is the NGS test?
NGS technology offers high accuracy for detecting mutations, but results should be correlated with clinical findings.
What is the cost of the test?
The CLCF1 Gene CISS2 NGS Genetic Test costs INR 20,000 at DNA Labs India, with free home sample collection available.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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