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CLCN5 Gene Dent disease NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

CLCN5 Gene Dent disease NGS Genetic Test

Short Name: CLCN5 Gene Dent Disease Test

Also known as: Dent Disease Genetic Test, CLCN5 Mutation Analysis, Dent Disease NGS Panel

CLCN5 Gene Dent disease NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic TestMalePediatric and Adult🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To confirm diagnosis of Dent disease by detecting mutations in the CLCN5 gene using Next-Generation Sequencing, aiding in clinical management and genetic counseling.

Test Code
2586
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Genetic counseling is recommended. No special preparation such as fasting is required.

Method: Venipuncture or FTA Card

Step 2

Laboratory Analysis

A blood sample will be drawn by a trained phlebotomist using sterile equipment, or a drop of blood can be collected on an FTA card.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bleeding. Store samples as per instructions.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling session to discuss test implications, draw a pedigree chart, and obtain informed consent.
2
During the Test:Sample is processed in the laboratory using NGS technology to sequence the CLCN5 gene.
3
After the Test:Results are reviewed by a geneticist and reported with interpretation. Follow-up counseling is recommended.

About This Test

Who Should Get This Test

To confirm diagnosis of Dent disease by detecting mutations in the CLCN5 gene using Next-Generation Sequencing, aiding in clinical management and genetic counseling.

How to Prepare

  • Ensure proper patient identification and labeling
  • Use sterile collection tubes or FTA cards
  • Follow standard phlebotomy procedures
  • Transport samples at ambient room temperature

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic diagnosis of Dent disease allows for timely intervention to preserve kidney function and manage symptoms effectively."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or FTA Card

Sample Stability

Blood sample stable for 24 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed or lipemic samples
  • Insufficient sample volume
  • Improperly labeled or contaminated samples
  • Samples not stored correctly

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the CLCN5 gene, which is associated with Dent disease.
Positive result: Pathogenic mutation detected, consistent with Dent disease diagnosis
Negative result: No pathogenic mutation detected, but clinical suspicion remains, consider further testing or clinical evaluation
Variant of uncertain significance (VUS): Requires additional analysis, genetic counseling, and correlation with clinical data
⚠️ When to Consult a Doctor:

If symptoms such as frequent urination, kidney stones, or blood in urine persist or worsen, consult a nephrologist or geneticist for evaluation and management.

Limitations

  • ⚠May not detect all types of mutations or variants of uncertain significance
  • ⚠Requires interpretation by a qualified geneticist
  • ⚠Results should be correlated with clinical findings and family history

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Psychological impact of genetic results, requiring counseling
  • ●Potential for uncertain results, leading to further testing

Interfering Factors

  • ●Sample contamination
  • ●DNA degradation
  • ●Technical errors in sequencing
  • ●Hemolyzed or lipemic samples

Compare With Similar Tests

TestCLCN5 Gene Dent disease NGS Genetic Test
ComparisonCLCN5 Gene Dent disease NGS Genetic Test

Frequently Asked Questions

What is Dent disease?
Dent disease is a rare genetic disorder primarily affecting males, caused by mutations in the CLCN5 gene, leading to kidney damage, kidney stones, and impaired kidney function.
What causes Dent disease?
Dent disease is caused by mutations in the CLCN5 gene, which regulates ion balance in the kidneys. It is inherited in an X-linked recessive pattern.
What are the symptoms of Dent disease?
Symptoms include frequent urination, painful urination, blood in urine, kidney stones, weakness, fatigue, and difficulty concentrating. It can progress to chronic kidney disease.
How is Dent disease diagnosed?
Diagnosis involves physical exam, medical history, blood and urine tests, and genetic testing such as the CLCN5 Gene NGS Test to confirm mutations.
What is the CLCN5 Gene Dent Disease NGS Genetic Test?
It is a Next-Generation Sequencing test that analyzes the CLCN5 gene for mutations to diagnose Dent disease accurately.
How much does the test cost?
The test costs INR 20,000 in India, with free home sample collection available in many cities.
Is the test covered by insurance?
Some insurance plans may cover genetic testing, but coverage varies. Check with your insurance provider for details.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, free home sample collection is available for online bookings across India in numerous cities.
What should I do before the test?
Genetic counseling is recommended before testing. No fasting or special preparation is required.
What do the results mean?
A positive result indicates a mutation in the CLCN5 gene, confirming Dent disease. A negative result means no mutation was detected, but further evaluation may be needed.
Who should consider this test?
Individuals with symptoms of Dent disease, a family history of the disorder, or those with unexplained kidney issues should consider this test.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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