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DNA Labs India

CLDN14 Gene Deafness, autosomal recessive type 29 NGS Genetic Test

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CLDN14 Gene Deafness, autosomal recessive type 29 NGS Genetic Test

Short Name: CLDN14 Deafness Test

Also known as: DFNB29, CLDN14-related hearing loss

CLDN14 Gene Deafness, autosomal recessive type 29 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3-4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify mutations in the CLDN14 gene that cause autosomal recessive deafness type 29, aiding in diagnosis and genetic counseling.

Test Code
2336
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3-4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Inform patient about test purpose and procedure. Ensure genetic counseling is arranged.

Method: Venipuncture

Step 2

Laboratory Analysis

Standard blood draw protocol using sterile technique.

Step 3

Report Delivery

Label sample correctly with patient details and transport to laboratory at recommended temperature.

Timeline: 3-4 weeks

Patient Instructions

1
Before the Test:Genetic counseling recommended to discuss implications and family history.
2
During the Test:Blood sample collection via venipuncture.
3
After the Test:Results will be discussed with a genetic counselor for interpretation and next steps.

About This Test

Who Should Get This Test

To identify mutations in the CLDN14 gene that cause autosomal recessive deafness type 29, aiding in diagnosis and genetic counseling.

How to Prepare

  • Fasting not required
  • Use EDTA tube for blood collection
  • Store sample at 2-8°C if not processed immediately
  • Ensure proper documentation

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for CLDN14 is vital for identifying carriers and affected individuals, enabling early intervention and family planning."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume3 ml
ContainerEDTA tube
Collection MethodVenipuncture

Sample Stability

Blood: 24 hours at room temperature
Extracted DNA: Stable for years at -20°C
Sample Rejection Criteria:
  • Hemolyzed sample
  • Incorrect sample type
  • Insufficient volume
  • Improper labeling

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the CLDN14 gene, which are associated with autosomal recessive deafness type 29.
Positive: Pathogenic mutation detected, confirm with clinical assessment and genetic counseling
Negative: No mutations found, but does not exclude other genetic causes; consider further testing
Variant of uncertain significance: Further testing or family studies recommended
⚠️ When to Consult a Doctor:

After receiving a positive result or if there are concerns about hearing loss or family history of deafness.

Limitations

  • ⚠May not detect all types of mutations
  • ⚠Results require clinical correlation
  • ⚠Does not rule out other genetic causes of deafness

Risks & Considerations

  • ●Minimal risk from blood draw: bruising, infection, or discomfort

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Insufficient sample volume

Compare With Similar Tests

TestCLDN14 Gene Deafness, autosomal recessive type 29 NGS Genetic TestGJB2 Gene Deafness TestSLC26A4 Gene AnalysisOTOF Gene SequencingComprehensive Hearing Loss Panel
ComparisonCLDN14 Gene Deafness, autosomal recessive type 29 NGS Genetic Test

Frequently Asked Questions

What is the CLDN14 gene deafness test?
It is a genetic test using NGS technology to detect mutations in the CLDN14 gene that cause autosomal recessive deafness type 29.
How is the test performed?
A blood sample is collected and analyzed using Next-Generation Sequencing to identify mutations in the CLDN14 gene.
What does a positive result mean?
A positive result indicates the presence of pathogenic mutations, confirming a diagnosis of CLDN14-related deafness, and may guide management and family planning.
Is the test painful?
The test involves a standard blood draw, which may cause minor discomfort or bruising, but is generally not painful.
How much does the test cost?
The test costs INR 20,000, which includes sample collection and analysis.
Is home collection available?
Yes, free home sample collection is available for online bookings across India in numerous cities.
What are the symptoms of CLDN14 gene deafness?
Symptoms include partial or complete hearing loss, which can be mild to severe, and may be accompanied by tinnitus.
Can the test be done for prenatal diagnosis?
Prenatal testing may be possible through specialized genetic counseling, but typically the test is recommended postnatally or for carrier screening.
How accurate is the NGS test?
NGS is highly accurate for detecting known and unknown mutations in the CLDN14 gene, providing reliable diagnostic results.
What is the turnaround time for results?
Results are typically available in 3 to 4 weeks after sample collection.
Is genetic counseling included?
Genetic counseling is recommended and can be arranged to discuss test results and implications.
Are there any risks associated with the test?
Risks are minimal, similar to a standard blood draw, including bruising or infection at the site.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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