Clozapine Test
Also known as: Clozapine Level Test, Clozapine Monitoring Test, Antipsychotic Drug Monitoring
Clozapine Test test available at DNA Labs India for ₹12,000. Uses LC-MS/MS on Serum from Red Top (No Additive) tube samples. Results in Reports available after 2-3 weeks from sample collection date.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The purpose of the Clozapine Test is to monitor blood levels of clozapine and its metabolite norclozapine, ensuring the medication remains within a therapeutic range to effectively manage schizophrenia symptoms while minimizing the risk of adverse effects such as agranulocytosis, seizures, and metabolic disturbances. It assists in dosage adjustment, compliance verification, and early detection of potential toxicity.
- Test Code
- 333
- Price
- ₹12,000
- Sample Type
- Serum from Red Top (No Additive) tube
- Result Time
- Reports available after 2-3 weeks from sample collection date.
- Fasting Required
- No
- Method
- LC-MS/MS
Sample Collection
Recommended specimen: 0.5 to 1 hour before next oral dose at steady state. Duly filled Test Send Out Consent Form (Form 35) is mandatory. No fasting required, but timing relative to dose is critical.
Method: Venipuncture
Laboratory Analysis
Standard venipuncture procedure: blood is drawn from a vein into a red top tube without additives.
Report Delivery
Ship sample refrigerated or frozen. Ensure proper labeling and documentation as per laboratory guidelines.
Timeline: Reports available after 2-3 weeks from sample collection date.
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the Clozapine Test is to monitor blood levels of clozapine and its metabolite norclozapine, ensuring the medication remains within a therapeutic range to effectively manage schizophrenia symptoms while minimizing the risk of adverse effects such as agranulocytosis, seizures, and metabolic disturbances. It assists in dosage adjustment, compliance verification, and early detection of potential toxicity.
How to Prepare
- Collect 2 mL (minimum 1 mL) serum from 1 Red Top (No Additive) tube
- Do not use SST gel barrier tubes
- Draw blood 0.5 to 1 hour before next oral dose at steady state
- Complete and submit Test Send Out Consent Form (Form 35)
- Ship sample refrigerated or frozen to maintain stability
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"Regular monitoring of clozapine levels is essential to prevent life-threatening side effects such as agranulocytosis and to ensure therapeutic efficacy in schizophrenia management."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample in SST gel barrier tube
- Hemolyzed or insufficient sample volume
- Missing or incomplete consent form
- Improper sample timing or handling
Understanding Your Results
May indicate underdosing or non-compliance; consider dosage increase or adherence counseling
Level: Below therapeutic range
Indicates appropriate dosing; continue monitoring as scheduled
Level: Within therapeutic range
May indicate toxicity risk; consider dosage reduction and monitor for side effects
Level: Above therapeutic range
Consult your doctor if test results show levels outside the therapeutic range, or if you experience symptoms such as sore throat, fever, unusual bruising, seizures, or severe dizziness, which may indicate side effects of clozapine.
Limitations
- ⚠Not a diagnostic tool for schizophrenia; only for medication monitoring
- ⚠Results may vary based on individual metabolism and adherence
- ⚠Requires accurate timing of sample collection for reliable results
Risks & Considerations
- ●Minor bruising or soreness at the puncture site
- ●Rare risk of infection or excessive bleeding
- ●No significant risks associated with the test itself
Interfering Factors
- ●Other medications that affect clozapine metabolism
- ●Improper sample timing relative to dose
- ●Hemolyzed or lipemic samples
- ●Non-compliance with pre-test instructions
Compare With Similar Tests
| Test | Clozapine Test | Complete Blood Count (CBC) | Liver Function Test (LFT) | Other Antipsychotic Monitoring Tests |
|---|---|---|---|---|
| Comparison | Clozapine Test | Monitors for agranulocytosis, a serious side effect of clozapine, but does not measure drug levels | Assesses liver health affected by clozapine, complementary to drug level monitoring | Similar purpose for different medications; clozapine test is specific to clozapine and its metabolite |
Frequently Asked Questions
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