COL11A2 Gene Deafness, autosomal dominant type 13 NGS Genetic Test
Short Name: COL11A2 Deafness Genetic Test
Also known as: DFNA13, Autosomal Dominant Deafness Type 13, COL11A2-related deafness
COL11A2 Gene Deafness, autosomal dominant type 13 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To diagnose autosomal dominant deafness type 13 (DFNA13) by detecting pathogenic mutations in the COL11A2 gene using NGS technology, enabling precise etiology identification, family risk assessment, and personalized clinical management.
- Test Code
- 2294
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- No
- Method
- Next Generation Sequencing (NGS)
Sample Collection
No special preparation required. Genetic counseling is recommended prior to testing.
Method: Venipuncture
Laboratory Analysis
A blood sample will be collected by a trained phlebotomist via venipuncture, typically taking 5-10 minutes.
Report Delivery
Apply gentle pressure to the puncture site with a cotton ball to prevent bruising. Avoid heavy lifting with the affected arm for a few hours.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
To diagnose autosomal dominant deafness type 13 (DFNA13) by detecting pathogenic mutations in the COL11A2 gene using NGS technology, enabling precise etiology identification, family risk assessment, and personalized clinical management.
How to Prepare
- Stay hydrated before sample collection
- Inform the technician about any medications or supplements
- Wear loose clothing for easy access to the arm
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"Genetic testing for COL11A2 mutations can confirm diagnosis and guide family counseling, enabling personalized management of hearing loss."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted samples
- Insufficient sample volume
- Samples without proper labeling
Understanding Your Results
Positive for pathogenic COL11A2 mutation
Confirms diagnosis of autosomal dominant deafness type 13; genetic counseling and family testing recommended.
Negative for pathogenic mutations
No COL11A2 mutation detected; consider other genetic or non-genetic causes of hearing loss.
Variant of Uncertain Significance (VUS)
Further clinical correlation and family studies needed; may require follow-up testing.
If you have a family history of deafness, experience progressive hearing loss, or symptoms like tinnitus, consult a geneticist or ENT specialist for evaluation and potential genetic testing.
Limitations
- ⚠Does not rule out all genetic causes of deafness
- ⚠Results may have variants of uncertain significance (VUS)
- ⚠Requires correlation with clinical and family history
Risks & Considerations
- ●Minimal risk from blood draw, such as pain, bruising, or infection
- ●Potential psychological impact of genetic results
Interfering Factors
- ●Sample contamination
- ●DNA degradation due to improper storage
- ●Technical errors in sequencing
Compare With Similar Tests
| Test | COL11A2 Gene Deafness, autosomal dominant type 13 NGS Genetic Test | GJB2 Gene Deafness Test | SLC26A4 Gene Test | Comprehensive Hearing Loss Panel | Whole Exome Sequencing (WES) |
|---|---|---|---|---|---|
| Comparison | COL11A2 Gene Deafness, autosomal dominant type 13 NGS Genetic Test | Targets a different gene (GJB2) commonly associated with autosomal recessive deafness. | Focuses on Pendred syndrome and enlarged vestibular aqueduct, a different type of hereditary hearing loss. | Screens multiple genes associated with hearing loss, broader than single-gene testing. | Analyzes all protein-coding genes, useful for undiagnosed cases but more expensive and complex. |
Frequently Asked Questions
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₹20,000Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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