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DNA Labs India

COL4A6 Gene Deafness, X-linked type 6 NGS Genetic Test

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COL4A6 Gene Deafness, X-linked type 6 NGS Genetic Test

Short Name: COL4A6 Deafness Test

Also known as: X-linked deafness type 6, COL4A6-related hearing loss

COL4A6 Gene Deafness, X-linked type 6 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify mutations in the COL4A6 gene responsible for X-linked type 6 deafness, aiding in accurate diagnosis, prognosis, and genetic counselling.

Test Code
2353
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation required. Sample collection by a healthcare professional is recommended.

Method: Venipuncture

Step 2

Laboratory Analysis

Blood will be drawn from a vein in the arm, or a drop of blood will be applied to an FTA card using sterile techniques.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Resume normal activities immediately.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counselling is recommended to understand test implications and family history.
2
During the Test:Sample collection as per protocol, followed by NGS analysis in a certified laboratory.
3
After the Test:Receive digital report and discuss results with a healthcare provider for management options.

About This Test

Who Should Get This Test

To identify mutations in the COL4A6 gene responsible for X-linked type 6 deafness, aiding in accurate diagnosis, prognosis, and genetic counselling.

How to Prepare

  • Sample collection at home or laboratory
  • Use sterile equipment and proper labeling
  • Ensure sample stability by following transport guidelines

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This NGS-based test provides precise identification of COL4A6 mutations, essential for diagnosis and genetic counselling in families with X-linked deafness."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture

Sample Stability

Blood samples stable at room temperature for 24 hours
Extracted DNA stable at -20°C for long-term storage
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Unlabeled or mislabeled specimens
  • Samples stored or transported incorrectly

Understanding Your Results

Results indicate whether a pathogenic variant in the COL4A6 gene is detected. A positive result confirms genetic deafness, while a negative result may require further testing or clinical evaluation.
Positive: Pathogenic variant detected – confirms diagnosis of COL4A6-related deafness
Negative: No variant detected – consider other genetic or non-genetic causes of hearing loss
Variant of uncertain significance – clinical correlation and genetic counselling recommended
⚠️ When to Consult a Doctor:

Consult a geneticist or ENT specialist if the test is positive, or if symptoms persist despite a negative result.

Limitations

  • ⚠Detects only variants in the COL4A6 gene; other causes of deafness may not be identified
  • ⚠Cannot determine the severity of hearing loss
  • ⚠Results may be uncertain for variants of unknown significance

Risks & Considerations

  • ●Minor bruising or discomfort at blood draw site
  • ●Very low risk of infection
  • ●Potential emotional impact of results

Interfering Factors

  • ●DNA degradation due to improper sample handling
  • ●Contamination with foreign DNA
  • ●Insufficient sample volume

Compare With Similar Tests

TestCOL4A6 Gene Deafness, X-linked type 6 NGS Genetic TestGJB2 Gene Deafness NGS TestSLC26A4 Gene Mutation Test
ComparisonCOL4A6 Gene Deafness, X-linked type 6 NGS Genetic Test

Frequently Asked Questions

What is COL4A6 Gene Deafness, X-linked type 6?
It is a genetic condition causing hearing loss due to mutations in the COL4A6 gene, inherited in an X-linked pattern.
Who should consider getting this test?
Individuals with unexplained hearing loss, family history of X-linked deafness, or those planning families with known history.
How is the NGS genetic test performed?
It involves sequencing DNA from a blood sample to detect mutations in the COL4A6 gene using advanced technology.
What samples are required for this test?
Blood, extracted DNA, or one drop of blood on an FTA card can be used.
Is fasting required before sample collection?
No, fasting is not required for this genetic test.
How long does it take to get the test results?
Results are typically available in 3 to 4 weeks after sample collection.
What does a positive test result mean?
A positive result confirms a mutation in the COL4A6 gene, indicating a genetic cause for deafness.
Can females be affected by X-linked deafness?
Females are usually carriers, but they may experience mild symptoms; males are primarily affected.
Is genetic counselling available with this test?
Yes, DNA Labs India provides genetic counselling to help interpret results and guide family planning.
What is the cost of the COL4A6 gene deafness test?
The test costs INR 20,000, with special discounts available for online bookings.
Is home sample collection available for this test?
Yes, free home sample collection is offered in numerous cities across India.
How accurate is the NGS genetic test for deafness?
NGS technology provides high accuracy in detecting genetic mutations, making it a reliable method for diagnosis.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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