COMT Gene Catechol-o-methyltransferase deficiency NGS Genetic Test
Short Name: COMT Deficiency NGS Test
Also known as: COMT deficiency test, Catechol-o-methyltransferase genetic test, COMT gene analysis
COMT Gene Catechol-o-methyltransferase deficiency NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
To diagnose Catechol-o-methyltransferase deficiency by detecting mutations in the COMT gene using NGS technology, enabling early intervention and personalized treatment plans.
- Test Code
- 4649
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- No
- Method
- NGS Technology
Sample Collection
No specific preparation required. Provide clinical history and undergo genetic counseling as per pre-test information.
Method: Venipuncture for blood samples; alternative methods for DNA or FTA card
Laboratory Analysis
A blood sample will be drawn via venipuncture, or alternative samples like extracted DNA or FTA card blood drop will be collected.
Report Delivery
Apply pressure to the puncture site to prevent bleeding. Resume normal activities unless otherwise advised.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
To diagnose Catechol-o-methyltransferase deficiency by detecting mutations in the COMT gene using NGS technology, enabling early intervention and personalized treatment plans.
How to Prepare
- Ensure proper identification and labeling of samples
- Follow aseptic techniques during collection
- Transport samples at ambient room temperature as specified
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This test is crucial for diagnosing COMT deficiency, which can impact mental health, metabolism, and reproductive outcomes. Early detection allows for personalized management strategies."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood samples
- Insufficient sample volume
- Improper labeling or documentation
Understanding Your Results
Pathogenic variant detected
Confirms diagnosis of COMT deficiency. Consult a geneticist for management and family screening.
No pathogenic variant detected
COMT deficiency unlikely based on this test. Consider other diagnoses if symptoms persist.
Variant of uncertain significance
Further testing or family studies may be needed. Genetic counseling recommended.
Consult a healthcare provider if you experience symptoms like depression, anxiety, focus issues, or have a family history of COMT deficiency. After receiving test results, seek genetic counseling for personalized advice.
Limitations
- ⚠May not detect all genetic variants or novel mutations
- ⚠Results require correlation with clinical symptoms and family history
- ⚠Does not assess other genes or conditions with similar symptoms
Risks & Considerations
- ●Minor bruising or discomfort at the blood draw site
- ●Rare risk of infection or fainting
- ●Psychological impact of genetic results; counseling provided
Interfering Factors
- ●Poor sample quality or insufficient DNA
- ●Contamination during sample collection or processing
- ●Recent blood transfusions may affect DNA analysis
Frequently Asked Questions
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Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.
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