Coxsackie A Antibody Panel Test
Short Name: Coxsackie A Ab Panel
Also known as: Coxsackie A Serology Test, Enterovirus A Antibody Panel, Coxsackie A Complement Fixation Test, Coxsackie Virus A Antibody Test
Coxsackie A Antibody Panel Test test available at DNA Labs India for ₹18,000. Uses Complement Fixation on Serum samples. Results in Reports are typically available 2-3 weeks after the laboratory receives the sample. Samples should be submitted by the 7th of the month for timely processing. Reports can be accessed via the online portal, email, or WhatsApp.. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr Kothari Ramesh Shantilal
Consultant Microbiologist · Reg: 27670
Last reviewed: September 7, 2026
Overview
The primary purpose of the Coxsackie A Antibody Panel Test is to confirm a clinical suspicion of Coxsackie A virus infection by detecting specific antibodies in the patient's blood. This test helps differentiate Coxsackie A infection from other viral illnesses with similar presentations, guides appropriate clinical management, and helps assess whether an infection is recent (IgM positive) or past (IgG positive). It is also valuable in epidemiological investigations and in evaluating patients with complications such as aseptic meningitis, encephalitis, or viral myocarditis where enteroviral aetiology is suspected.
- Test Code
- 367
- CPT Code
- 86658
- ICD Code
- B08.4
- Price
- ₹18,000
- Sample Type
- Serum
- Result Time
- Reports are typically available 2-3 weeks after the laboratory receives the sample. Samples should be submitted by the 7th of the month for timely processing. Reports can be accessed via the online portal, email, or WhatsApp.
- Fasting Required
- No
- Method
- Complement Fixation
Sample Collection
Ensure the Test Send Out Consent Form (Form 35) is duly filled and signed. Inform the phlebotomist about any current medications, recent vaccinations, or immunoglobulin therapy. No fasting is required for this test.
Method: Venipuncture
Laboratory Analysis
A standard venipuncture will be performed. Approximately 2 mL of blood will be collected into a Serum Separator Tube (SST). The procedure typically takes less than 5 minutes.
Report Delivery
Apply pressure to the venipuncture site for 3-5 minutes. Mild bruising may occur and is normal. Resume normal activities immediately. The sample will be processed and shipped to the reference laboratory under refrigerated or frozen conditions.
Timeline: Reports are typically available 2-3 weeks after the laboratory receives the sample. Samples should be submitted by the 7th of the month for timely processing. Reports can be accessed via the online portal, email, or WhatsApp.
Patient Instructions
About This Test
Who Should Get This Test
The primary purpose of the Coxsackie A Antibody Panel Test is to confirm a clinical suspicion of Coxsackie A virus infection by detecting specific antibodies in the patient's blood. This test helps differentiate Coxsackie A infection from other viral illnesses with similar presentations, guides appropriate clinical management, and helps assess whether an infection is recent (IgM positive) or past (IgG positive). It is also valuable in epidemiological investigations and in evaluating patients with complications such as aseptic meningitis, encephalitis, or viral myocarditis where enteroviral aetiology is suspected.
How to Prepare
- Duly filled Test Send Out Consent Form (Form 35) is mandatory before sample collection
- Collect 2 mL (1 mL min.) serum from 1 SST tube
- Ship sample refrigerated or frozen
- Label the sample correctly with patient details and date of collection
- Ensure sample reaches the laboratory within stability guidelines
- Sample should be submitted by the 7th of the month for timely report processing
Doctor's Notes
Reviewed by Dr Kothari Ramesh Shantilal — MBBS, MD (Microbiology) · Reg. No. 27670
"Coxsackie A virus infections are frequently encountered in clinical practice, especially in paediatric populations. Hand, foot, and mouth disease and herpangina are the most common presentations. While many infections are self-limiting, certain serotypes can cause serious complications including viral meningitis, encephalitis, and myocarditis. This antibody panel is particularly useful when clinical presentation is atypical or when there is a need to differentiate Coxsackie A from other enteroviral infections. I recommend this test for patients presenting with undifferentiated febrile illness accompanied by mucocutaneous manifestations suggestive of enteroviral aetiology."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Sample received without a duly filled Test Send Out Consent Form (Form 35)
- Hemolyzed, lipemic, or grossly contaminated samples
- Sample received beyond the specified stability period
- Incorrect sample type or insufficient sample volume
- Improperly labeled or unlabeled samples
Understanding Your Results
All titers < 1:8
Negative. No detectable antibodies to any of the Coxsackie A serotypes tested. This may indicate no prior exposure or testing performed too early in the course of infection. If clinical suspicion remains high, repeat testing with a convalescent sample after 2-4 weeks is recommended.
Single or multiple serotype titers ≥ 1:8 (single sample)
Borderline or positive. Elevated antibody titers may suggest current or past infection with the corresponding Coxsackie A serotype(s). A fourfold or greater rise in titer between acute and convalescent samples confirms recent active infection.
Fourfold or greater rise in titer between paired sera
Confirmed recent or active Coxsackie A virus infection. This result indicates seroconversion or a significant rise in antibody levels, strongly supporting a diagnosis of recent Coxsackie A infection caused by the identified serotype(s).
Elevated titer in single sample with compatible clinical presentation
Probable Coxsackie A infection. A single elevated titer in a patient with characteristic symptoms (HFMD, herpangina, meningitis) may be considered supportive of diagnosis, though paired sera confirmation is preferred.
Consult your doctor if you experience high fever with sore throat and oral blisters, a rash on the hands and feet, severe headache with neck stiffness, chest pain or difficulty breathing, or if your symptoms worsen despite supportive care. In children, watch for refusal to eat or drink due to mouth sores, high fever, or signs of dehydration. Seek immediate medical attention if there are signs of complications such as meningitis, encephalitis, or myocarditis.
Limitations
- ⚠Complement fixation testing does not distinguish between IgM and IgG antibodies separately; clinical correlation with timing of symptoms is necessary
- ⚠A single titer result cannot reliably differentiate between recent and past infection; paired sera (acute and convalescent) collected 2-4 weeks apart are recommended for definitive interpretation
- ⚠Cross-reactivity among enterovirus serotypes may reduce serotype specificity
- ⚠The test may not detect antibodies in immunocompromised or severely ill patients with impaired immune responses
- ⚠This is a send-out test; turnaround time is longer compared to in-house diagnostics
Risks & Considerations
- ●Minor bruising or discomfort at the venipuncture site
- ●Slight risk of infection at the blood collection site
- ●Rarely, lightheadedness or fainting during blood draw
- ●False-negative results if tested too early in the infection course
- ●Cross-reactivity with other enteroviruses may lead to ambiguous results
Interfering Factors
- ●Immunocompromised patients may produce lower or undetectable antibody levels
- ●Recent blood transfusions or immunoglobulin therapy may affect antibody results
- ●Early-stage infection (within first 5-7 days) may yield false-negative IgM results
- ●Cross-reactivity with other enteroviruses may lead to non-specific reactions
- ●Patients on immunosuppressive medications may have attenuated antibody responses
Compare With Similar Tests
| Test | Coxsackie A Antibody Panel Test | Coxsackie B Antibody Panel | Enterovirus PCR Test | Viral Meningitis Panel |
|---|---|---|---|---|
| Comparison | Coxsackie A Antibody Panel Test | The Coxsackie B panel detects antibodies to Coxsackie B serotypes (B1-B6), which are more commonly associated with myocarditis and pleurodynia. The A panel covers serotypes A2, A4, A7, A9, A10, and A16, which are more associated with HFMD and herpangina. | Enterovirus PCR detects viral RNA directly and can identify infection earlier than antibody tests (within 1-3 days of symptom onset). The antibody panel is useful when PCR is negative or unavailable, or to assess immune response. | A broader panel that tests for multiple causes of viral meningitis, including enteroviruses, HSV, and arboviruses. The Coxsackie A panel is specific to Coxsackie A serotypes only. |
Frequently Asked Questions
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