Skip to main content
DNA Labs India

CR1 Gene CR1 deficiency NGS Genetic Test

DNA Labs India | ISO 9001:2015 Certified

CR1 Gene CR1 deficiency NGS Genetic Test

Short Name: CR1 Deficiency NGS

Also known as: Complement Receptor 1 Deficiency Genetic Test, CR1 Gene Mutation Analysis, NGS for CR1 Deficiency

CR1 Gene CR1 deficiency NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports will be delivered within 3 to 4 weeks from the date of sample receipt.. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 3, 2026

Overview

To detect pathogenic mutations in the CR1 gene for the genetic confirmation of CR1 deficiency, supporting clinical diagnosis, management, and genetic counselling.

Test Code
3980
ICD Code
D84.1
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Reports will be delivered within 3 to 4 weeks from the date of sample receipt.
Fasting Required
No
Method
Next Generation Sequencing (NGS)
Step 1

Sample Collection

No specific preparation is needed. No fasting required. Kindly provide a detailed clinical history and list of medications. A genetic counselling session may be conducted before sample collection to draw a pedigree chart.

Method: Blood draw or FTA card spot

Step 2

Laboratory Analysis

A healthcare professional will draw a blood sample from your arm, or a few drops of blood may be collected on an FTA card. The procedure is quick and involves minimal discomfort.

Step 3

Report Delivery

You may resume normal activities immediately after sample collection. If you experience any dizziness or prolonged bleeding, inform the medical staff.

Timeline: Reports will be delivered within 3 to 4 weeks from the date of sample receipt.

Patient Instructions

1
Before the Test:No special preparation is required. Inform your doctor about any medications or blood transfusions in the past 3 months.
2
During the Test:A blood sample will be collected by venipuncture or via FTA card. The procedure takes about 5-10 minutes.
3
After the Test:You can resume normal activities. The sample will be sent to our NGS laboratory for analysis. Your report will be shared online via email/WhatsApp.

About This Test

Who Should Get This Test

To detect pathogenic mutations in the CR1 gene for the genetic confirmation of CR1 deficiency, supporting clinical diagnosis, management, and genetic counselling.

How to Prepare

  • No fasting required
  • Submit clinical history and medication list
  • Attend a genetic counselling session before testing
  • Home sample collection available - book online

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Genetic testing for CR1 deficiency is crucial for accurately diagnosing complement system disorders, enabling timely management of infections and associated autoimmune complications."

Last medically reviewed: September 3, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeNot Specified
ContainerEDTA tube or FTA Card
Collection MethodBlood draw or FTA card spot

Sample Stability

Blood sample stable for 72 hours at room temperature
Stable at 2-8°C for up to 7 days
Do not freeze whole blood
Sample Rejection Criteria:
  • Clotted sample
  • Unlabelled sample
  • Incomplete requisition form
  • Sample received in inappropriate transport medium

Understanding Your Results

The NGS genetic test for CR1 deficiency analyzes the CR1 gene for mutations. The result is reported as positive (pathogenic variant found), negative (no pathogenic variant), or a variant of uncertain significance (VUS).
Positive result: A pathogenic mutation in CR1 gene confirms the diagnosis of CR1 deficiency. Genetic counselling is recommended for family planning and management.
Negative result: No pathogenic variant detected. However, this does not completely rule out CR1 deficiency, especially in cases with strong clinical suspicion.
Variant of Uncertain Significance: A genetic change was found, but its impact is unknown. Further segration and functional studies may be needed.
⚠️ When to Consult a Doctor:

Consult a clinical geneticist or immunologist if you have recurrent infections, a family history of CR1 deficiency, or symptoms suggestive of an immune disorder with renal or hematological involvement.

Limitations

  • ⚠This test detects mutations in the CR1 gene only
  • ⚠It does not assess complement receptor 1 protein expression or function
  • ⚠Rare large deletion/duplication may not be identified by standard NGS sequencing

Risks & Considerations

  • ●Minimal pain or discomfort during blood draw
  • ●Small risk of bruising, bleeding, or hematoma at the puncture site
  • ●Rare risk of infection or vasovagal reaction

Interfering Factors

  • ●Recent blood transfusion may interfere with DNA analysis – notify your clinician
  • ●Clotted or hemolysed blood sample may reduce test accuracy

Frequently Asked Questions

What is CR1 deficiency?
CR1 deficiency is a rare genetic disorder caused by mutations in the CR1 gene, affecting the complement receptor 1 protein. This leads to impaired immune regulation, increased susceptibility to infections, and risk of autoimmune disorders.
What are the symptoms of CR1 deficiency?
Common symptoms include recurrent respiratory tract infections, anemia, reduced kidney function, increased risk of autoimmune disorders. Symptoms vary in severity based on the extent of deficiency.
How is CR1 deficiency diagnosed?
CR1 deficiency is diagnosed through genetic testing that analyzes the CR1 gene. It can be performed on a blood sample or FTA card. The test is recommended for individuals with suspicious symptoms or a family history.
What is the cost of the CR1 NGS genetic test in India?
The cost is approximately INR 20,000 at DNA Labs India. Discounted price may be available for online bookings, and free home sample collection is offered.
Is home sample collection available for this test?
Yes, DNA Labs India provides free home sample collection for online bookings for the CR1 NGS genetic test in major cities across India.
How long does the test take?
The turnaround time for the CR1 NGS genetic test is 3 to 4 weeks from the date of sample receipt.
What is the sample type required for the CR1 NGS test?
The sample can be blood, extracted DNA, or one drop of blood on an FTA card. For standard blood sample, an EDTA tube is typically used.
Do I need to fast before the test?
No, fasting is not required for this genetic test.
Can this test be done on children?
Yes, the test can be performed on individuals of any age, including children, when clinically indicated.
Will health insurance cover the cost?
Coverage depends on the insurance provider and policy. It is advised to check with your insurance provider before undergoing the test. Some schemes like PMJAY or private insurers might provide partial or full coverage.
What does a negative test result mean?
A negative result means no pathogenic mutation was detected in the CR1 gene. This reduces the likelihood of CR1 deficiency but does not entirely rule it out if clinical suspicion is high.
How do I book this test?
You can book online on the DNA Labs India website. Free home sample collection is available for online bookings. Alternatively, you can visit a nearby DNA Labs India collection center.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

Related Tests

ACAT1 Gene Methylacetoacetic aciduria NGS Genetic Test

₹20,000

SERHL2 Gene Serine hydrolase deficiency, SERHL2 related NGS Genetic Test

₹20,000

Comprehensive Ear Nose Throat Panel NGS Genetic Test

₹20,000

ATAC Sequencing

₹48,000

PTF1A Gene Pancreatic and cerebellar agenesis NGS Genetic Test

₹20,000

IARS2 Gene Cataracts, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia NGS Genetic Test

₹20,000
For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

Book Your Test

Enter your details and we'll connect you within 15 minutes.

🧬

Quick Connect

Enter your mobile number and we’ll connect you with the team.

+91

✅ Connecting you now...

🔒 Your number is used to respond to this request.