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CRLF1 Gene Cold-induced sweating syndrome NGS Genetic Test

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CRLF1 Gene Cold-induced sweating syndrome NGS Genetic Test

Short Name: CRLF1 Gene CISS NGS Test

Also known as: Cold-Induced Sweating Syndrome, CRLF1-related disorder

CRLF1 Gene Cold-induced sweating syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks from sample receipt. Free home collection in 300+ cities across India.

PediatricsPediatric🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

To diagnose Cold-Induced Sweating Syndrome by detecting mutations in the CRLF1 gene using Next-Generation Sequencing (NGS) technology, aiding in clinical management and genetic counseling.

Test Code
5722
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks from sample receipt
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Clinical history of the patient and a genetic counseling session to draw a pedigree chart of family members affected with Cold-Induced Sweating Syndrome.

Method: Venipuncture

Step 2

Laboratory Analysis

Blood sample collected via venipuncture under sterile conditions.

Step 3

Report Delivery

Sample labeled and transported to the laboratory for NGS analysis.

Timeline: 3 to 4 weeks from sample receipt

Patient Instructions

1
Before the Test:Genetic counseling and clinical history review are recommended before testing.
2
During the Test:Next-Generation Sequencing (NGS) analysis is performed on the DNA sample to detect mutations in the CRLF1 gene.
3
After the Test:Results are reviewed by a geneticist and reported with interpretation guidance.

About This Test

Who Should Get This Test

To diagnose Cold-Induced Sweating Syndrome by detecting mutations in the CRLF1 gene using Next-Generation Sequencing (NGS) technology, aiding in clinical management and genetic counseling.

How to Prepare

  • Ensure proper patient identification
  • Use sterile collection equipment
  • Label sample with patient details and date
  • Store at ambient room temperature

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"This test is essential for diagnosing rare genetic disorders like CISS, enabling early intervention and family planning through genetic counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 mL
ContainerEDTA tube or FTA card
Collection MethodVenipuncture

Sample Stability

Blood sample stable at room temperature for 24 hours
Extracted DNA stable at -20°C for long-term storage
Sample Rejection Criteria:
  • Hemolyzed or clotted sample
  • Insufficient sample volume
  • Improper labeling or storage

Understanding Your Results

Results indicate the presence or absence of mutations in the CRLF1 gene associated with Cold-Induced Sweating Syndrome.
Positive: Pathogenic variant detected, consistent with CISS diagnosis
Negative: No pathogenic variants detected, CISS unlikely but clinical correlation needed
Variant of uncertain significance: Further testing or family studies recommended
⚠️ When to Consult a Doctor:

If symptoms of Cold-Induced Sweating Syndrome are present, or for genetic counseling and family planning after a positive result.

Limitations

  • ⚠May not detect all possible mutations in the CRLF1 gene
  • ⚠Requires genetic counseling for interpretation
  • ⚠Results should be correlated with clinical findings

Risks & Considerations

  • ●Minor bruising at blood draw site
  • ●Rare risk of infection
  • ●Fainting or dizziness during collection

Interfering Factors

  • ●Sample contamination
  • ●Improper sample storage or handling
  • ●Hemolyzed blood sample

Compare With Similar Tests

TestCRLF1 Gene Cold-induced sweating syndrome NGS Genetic TestWhole Exome SequencingNeurological Genetic Panel
ComparisonCRLF1 Gene Cold-induced sweating syndrome NGS Genetic Test

Frequently Asked Questions

What is Cold-Induced Sweating Syndrome?
Cold-Induced Sweating Syndrome (CISS) is a rare genetic disorder caused by mutations in the CRLF1 gene, leading to excessive sweating in cold temperatures and other neurological symptoms.
What causes CISS?
CISS is caused by mutations in the CRLF1 gene, which is inherited in an autosomal recessive pattern.
How is CISS diagnosed?
CISS is diagnosed through genetic testing, specifically Next-Generation Sequencing (NGS) of the CRLF1 gene, often confirmed with a blood sample.
What is the CRLF1 gene test?
The CRLF1 gene test is an NGS-based genetic test that detects mutations in the CRLF1 gene to diagnose Cold-Induced Sweating Syndrome.
How is the test performed?
The test involves collecting a blood sample, which is then analyzed using NGS technology to identify mutations in the CRLF1 gene.
What is the cost of the test?
The cost of the CRLF1 gene test at DNA Labs India is INR 20,000, including sample collection and analysis.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for online bookings across many cities in India.
Who should consider this test?
Individuals showing symptoms of CISS, such as excessive sweating in cold, delayed development, or family history of the disorder, should consider this test.
Are there any risks associated with the test?
The test involves a standard blood draw, which may cause minor bruising or discomfort; serious risks are minimal.
What do the results mean?
Positive results indicate a mutation in the CRLF1 gene, confirming CISS; negative results suggest no mutation, but clinical correlation is advised.
How can I prepare for the test?
No special preparation is needed, but genetic counseling is recommended before testing to understand implications and family history.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

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