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CRYM Gene Deafness, autosomal dominant type 40 NGS Genetic Test

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CRYM Gene Deafness, autosomal dominant type 40 NGS Genetic Test

Short Name: CRYM Gene Deafness NGS Test

Also known as: CRYM-related deafness, Autosomal Dominant Hearing Loss Type 40

CRYM Gene Deafness, autosomal dominant type 40 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS (Next-Generation Sequencing) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic TestPediatric to Adult🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to detect mutations in the CRYM gene to confirm a diagnosis of autosomal dominant deafness type 40, aiding in clinical management, genetic counseling, and family planning.

Test Code
2305
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS (Next-Generation Sequencing)
Step 1

Sample Collection

No specific preparation required. Inform the healthcare provider about any medications or medical conditions.

Method: Blood draw or saliva collection

Step 2

Laboratory Analysis

A blood sample will be drawn from a vein in the arm, or saliva may be collected using a kit.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Resume normal activities.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Consult with a genetic counselor to understand the test implications and provide family history.
2
During the Test:Sample collection via blood draw or saliva; process takes about 15-20 minutes.
3
After the Test:Results are reviewed by a geneticist and delivered online; follow-up counseling is advised.

About This Test

Who Should Get This Test

The purpose of this test is to detect mutations in the CRYM gene to confirm a diagnosis of autosomal dominant deafness type 40, aiding in clinical management, genetic counseling, and family planning.

How to Prepare

  • Fast for 8-12 hours if required for blood draw
  • Avoid eating or drinking before saliva collection
  • Ensure proper labeling of samples

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic testing for CRYM gene mutations aids in accurate diagnosis and management of progressive hearing loss in families with autosomal dominant deafness type 40."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs per collection method
ContainerSterile tube or FTA card
Collection MethodBlood draw or saliva collection

Sample Stability

Blood: Stable at room temperature for 24 hours
Extracted DNA: Stable refrigerated for longer periods
Sample Rejection Criteria:
  • Hemolyzed or clotted samples
  • Insufficient sample volume
  • Improperly labeled samples

Understanding Your Results

Results indicate whether pathogenic mutations in the CRYM gene are present, which are linked to autosomal dominant deafness type 40.
📊

Negative

No pathogenic variants detected; condition unlikely due to CRYM mutations.

📊

Positive

Pathogenic variant found; confirms diagnosis of autosomal dominant deafness type 40.

📊

Variant of uncertain significance

Further testing or genetic counseling recommended.

⚠️ When to Consult a Doctor:

Consult a geneticist or ENT specialist if you experience progressive hearing loss, have a family history of deafness, or receive a positive test result for genetic counseling and management.

Limitations

  • ⚠May not detect all rare genetic variants
  • ⚠Results require clinical correlation
  • ⚠Does not assess other genes involved in hearing loss

Risks & Considerations

  • ●Minor bruising at blood draw site
  • ●Very low risk of infection

Interfering Factors

  • ●Hemolyzed blood samples
  • ●Degraded DNA from improper storage

Compare With Similar Tests

TestCRYM Gene Deafness, autosomal dominant type 40 NGS Genetic TestGJB2 Gene TestSLC26A4 Gene TestComprehensive Hearing Loss PanelMITOCHONDRIAL DNA Mutation Test
ComparisonCRYM Gene Deafness, autosomal dominant type 40 NGS Genetic Test

Frequently Asked Questions

What is CRYM gene deafness?
CRYM gene deafness is an autosomal dominant type 40 genetic disorder causing progressive hearing loss due to mutations in the CRYM gene.
Who should consider this genetic test?
Individuals with progressive hearing loss, family history of deafness, or symptoms like tinnitus and balance issues.
How is the sample collected for this test?
Samples can be collected via blood draw or saliva, with home collection available.
What does a positive test result mean?
A positive result confirms mutations in the CRYM gene, diagnosing autosomal dominant deafness type 40.
Is genetic counseling recommended before testing?
Yes, genetic counseling helps understand implications and guides decision-making.
What is the cost of the CRYM Gene Deafness NGS Test?
The test costs INR 20,000, including kit, collection, and analysis.
How long does it take to get results?
Results are typically available within 3 to 4 weeks.
Are there any risks associated with the test?
Risks are minimal, such as bruising from blood draw, with no significant side effects.
Can this test detect other types of deafness?
No, it specifically targets CRYM gene mutations for autosomal dominant deafness type 40.
Is home sample collection available?
Yes, free home collection is offered for online bookings across India.
What should I do after receiving the results?
Consult a geneticist or ENT specialist for interpretation and management planning.
Is this test suitable for children?
Yes, it can be performed on individuals of all ages, including children with symptoms.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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