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DCDC2 Gene Deafness, autosomal recessive type 66 NGS Genetic Test

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DCDC2 Gene Deafness, autosomal recessive type 66 NGS Genetic Test

Short Name: DCDC2 Deafness NGS Test

Also known as: DFNB66, Autosomal Recessive Deafness 66

DCDC2 Gene Deafness, autosomal recessive type 66 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To identify pathogenic mutations in the DCDC2 gene associated with autosomal recessive deafness type 66, enabling definitive diagnosis, carrier detection, and informed genetic counseling.

Test Code
4749
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

No special preparation required. Provide detailed clinical history and family pedigree for genetic counseling.

Method: Venipuncture or finger prick

Step 2

Laboratory Analysis

A trained phlebotomist will collect a blood sample via venipuncture or a saliva sample as per instructions.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Resume normal activities unless otherwise advised.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Provide clinical history and undergo genetic counseling to understand implications.
2
During the Test:Sample collection is quick and minimally invasive, performed by a healthcare professional.
3
After the Test:Results are delivered in 3-4 weeks; follow up with a geneticist for interpretation.

About This Test

Who Should Get This Test

To identify pathogenic mutations in the DCDC2 gene associated with autosomal recessive deafness type 66, enabling definitive diagnosis, carrier detection, and informed genetic counseling.

How to Prepare

  • Fast for 4 hours if specified by the physician
  • Avoid strenuous physical activity before sample collection
  • Bring identification, doctor's prescription, and family history details
  • Ensure proper labeling of samples

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early genetic diagnosis of DCDC2 mutations can guide management and family counseling for hereditary deafness."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume3-5 ml blood
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or finger prick

Sample Stability

Blood samples are stable for 48 hours at room temperature
Extracted DNA can be stored at -20°C for longer periods
FTA card samples are stable at room temperature for extended durations
Sample Rejection Criteria:
  • Hemolyzed or clotted blood samples
  • Insufficient sample volume
  • Improperly labeled or contaminated samples
  • Samples without proper documentation

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the DCDC2 gene, guiding diagnosis and management of autosomal recessive deafness type 66.
Positive result: Pathogenic mutation detected, confirming diagnosis or carrier status
Negative result: No pathogenic variants found, but clinical correlation is advised
Variant of uncertain significance: Requires further analysis and genetic counseling
Carrier status: Individual carries one mutated copy, typically asymptomatic but can pass to offspring
⚠️ When to Consult a Doctor:

If you experience symptoms of hearing loss, have a family history of genetic deafness, or are planning a family with risk of hereditary conditions.

Limitations

  • ⚠May not detect all genetic variants or novel mutations
  • ⚠Requires genetic counseling for accurate interpretation
  • ⚠Not a screening test for all causes of deafness
  • ⚠Results may have variants of uncertain significance

Risks & Considerations

  • ●Minor bruising or discomfort at the blood draw site
  • ●Rare risk of infection at puncture site
  • ●Psychological impact of genetic results

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Hemolysis in blood sample
  • ●Improper storage conditions

Frequently Asked Questions

What is DCDC2 gene deafness?
DCDC2 gene deafness is a genetic condition caused by mutations in the DCDC2 gene, leading to autosomal recessive type 66 deafness, which affects the auditory system and causes hearing loss.
How is autosomal recessive type 66 inherited?
It is inherited in an autosomal recessive pattern, meaning an individual must inherit two mutated copies of the DCDC2 gene, one from each parent, to be affected.
What are the common symptoms of DCDC2 gene deafness?
Symptoms include difficulty hearing sounds, needing higher volume on devices, frequently asking for repetition, trouble understanding speech in noise, and gradual hearing loss.
How is the NGS genetic test performed?
The test uses Next-Generation Sequencing to analyze DNA from a blood or saliva sample, detecting mutations in the DCDC2 gene with high accuracy.
What is the cost of the DCDC2 gene deafness test in India?
The cost is INR 20000 at DNA Labs India, which includes sample collection, analysis, and report generation.
Is the test covered by insurance?
Coverage varies by insurance provider; it is advisable to check with your insurer directly. Genetic testing may not be routinely covered.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What does a positive test result mean?
A positive result indicates the presence of a pathogenic DCDC2 mutation, confirming diagnosis of deafness or carrier status, requiring genetic counseling.
Can carriers of DCDC2 mutations have symptoms?
Carriers usually do not show symptoms of deafness but can pass the mutation to their children, especially if both parents are carriers.
Is genetic counseling recommended before and after the test?
Yes, genetic counseling is highly recommended to understand the implications, interpret results, and discuss family planning options.
How accurate is the NGS genetic test for DCDC2 gene deafness?
NGS testing is highly accurate for detecting known mutations, but it may not identify all variants; clinical correlation is essential.
Where can I get this test done?
You can book the test at DNA Labs India with home sample collection available across major cities in India, including Mumbai, Delhi, Bangalore, and more.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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