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DLL4 Gene Adams-Oliver syndrome type 6 NGS Genetic Test

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DLL4 Gene Adams-Oliver syndrome type 6 NGS Genetic Test

Short Name: DLL4 AOS Type 6 NGS Test

Also known as: Adams-Oliver Syndrome Type 6 Genetic Test, DLL4 Gene Mutation Analysis

DLL4 Gene Adams-Oliver syndrome type 6 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS (Next-Generation Sequencing) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

PediatricsPediatric🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

The purpose of this test is to diagnose Adams-Oliver Syndrome Type 6 by identifying pathogenic mutations in the DLL4 gene using NGS technology, enabling accurate clinical management and genetic counseling.

Test Code
5642
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
NGS (Next-Generation Sequencing)
Step 1

Sample Collection

No special preparation is required. Ensure proper identification and consent.

Method: Venipuncture or FTA Card

Step 2

Laboratory Analysis

A blood sample will be drawn by a trained phlebotomist using sterile equipment.

Step 3

Report Delivery

Apply pressure to the puncture site to stop bleeding. Keep the area clean.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Consult with a genetic counselor to discuss the test, implications, and family history.
2
During the Test:Sample collection followed by NGS analysis in the laboratory.
3
After the Test:Receive the report and discuss results with a healthcare provider for management planning.

About This Test

Who Should Get This Test

The purpose of this test is to diagnose Adams-Oliver Syndrome Type 6 by identifying pathogenic mutations in the DLL4 gene using NGS technology, enabling accurate clinical management and genetic counseling.

How to Prepare

  • Verify patient identity and test details
  • Use aseptic technique for blood collection
  • Label samples correctly with patient information
  • Store samples at appropriate temperature until transport

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"Genetic testing for DLL4 gene mutations is crucial for accurate diagnosis and management of Adams-Oliver Syndrome Type 6, enabling personalized care and family planning."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Collection MethodVenipuncture or FTA Card

Sample Stability

Blood samples stable for 48 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed or lipemic samples
  • Insufficient sample volume
  • Improperly labeled or contaminated samples

Understanding Your Results

Results from the DLL4 Gene Adams-Oliver Syndrome Type 6 NGS Genetic Test should be interpreted by a healthcare professional in the context of clinical findings and family history.
Positive Result: Pathogenic variant detected in the DLL4 gene, confirming diagnosis of Adams-Oliver Syndrome Type 6.
Negative Result: No pathogenic variants detected; clinical correlation is needed, and other genetic tests may be considered.
Variant of Uncertain Significance (VUS): Mutation detected but significance unknown; further testing and family studies may be required.
⚠️ When to Consult a Doctor:

Consult a doctor if symptoms of Adams-Oliver Syndrome are present, such as scalp defects or limb malformations, or if there is a family history of the condition.

Limitations

  • ⚠May not detect all possible mutations in the DLL4 gene
  • ⚠Results require interpretation by a qualified geneticist
  • ⚠Does not rule out other genetic causes of similar symptoms

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Psychological impact of genetic results; counseling is recommended

Interfering Factors

  • ●Sample contamination or degradation
  • ●Insufficient DNA quantity or quality
  • ●Hemolyzed blood samples

Compare With Similar Tests

TestDLL4 Gene Adams-Oliver syndrome type 6 NGS Genetic TestARID1A Gene Adams-Oliver Syndrome Type 1 NGS TestEOGT Gene Adams-Oliver Syndrome Type 5 NGS TestChromosomal Microarray AnalysisWhole Exome Sequencing
ComparisonDLL4 Gene Adams-Oliver syndrome type 6 NGS Genetic Test

Frequently Asked Questions

What is Adams-Oliver Syndrome?
Adams-Oliver Syndrome is a rare genetic disorder characterized by scalp defects, limb malformations, and sometimes heart defects, caused by mutations in genes like DLL4.
What causes Adams-Oliver Syndrome Type 6?
Type 6 is specifically caused by mutations in the DLL4 gene, which disrupts blood vessel development and leads to the syndrome's symptoms.
How is the DLL4 Gene NGS Genetic Test performed?
The test uses Next-Generation Sequencing to analyze the DLL4 gene from a blood or DNA sample, identifying mutations associated with the syndrome.
What are the symptoms of DLL4 Gene Adams-Oliver Syndrome Type 6?
Symptoms include missing or underdeveloped fingers/toes, scalp defects, skull abnormalities, heart defects, and developmental delays.
Is the genetic test painful?
The test involves a standard blood draw, which may cause minor discomfort but is generally not painful.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India.
What is the cost of the test?
The test costs INR 20000, with no additional charges for home collection.
Is genetic counseling provided?
Yes, a genetic counseling session is included to help interpret results and provide support.
Can the test be used for prenatal diagnosis?
This test is typically for postnatal diagnosis; prenatal testing may require different methods and consultation with a specialist.
What if the test result is negative?
A negative result means no pathogenic variants were detected in the DLL4 gene, but clinical evaluation is still necessary as other genetic causes may exist.
How accurate is the NGS Genetic Test?
NGS technology is highly accurate for detecting mutations, but results should be interpreted by a qualified geneticist in the context of clinical findings.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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