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DLX3 Gene Trichodontoosseous syndrome NGS Genetic Test

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DLX3 Gene Trichodontoosseous syndrome NGS Genetic Test

Short Name: DLX3 Gene Test

Also known as: TDO Syndrome, Trichodontoosseous Syndrome

DLX3 Gene Trichodontoosseous syndrome NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

Next-Generation Sequencing (NGS)All Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to diagnose Trichodontoosseous syndrome by detecting mutations in the DLX3 gene using next-generation sequencing, aiding in clinical management and genetic counseling.

Test Code
5150
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Clinical history of the patient and a genetic counseling session to draw a pedigree chart of family members affected with Trichodontoosseous syndrome.

Method: Venipuncture or FTA card collection

Step 2

Laboratory Analysis

Standard blood collection procedure via venipuncture or FTA card collection.

Step 3

Report Delivery

Sample is sent to the laboratory for DNA extraction and NGS analysis.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical evaluation to assess symptoms and family history.
2
During the Test:Blood sample collection from a vein or using an FTA card.
3
After the Test:Wait for report delivery in 3 to 4 weeks and follow up with a genetic counselor for interpretation.

About This Test

Who Should Get This Test

The purpose of this test is to diagnose Trichodontoosseous syndrome by detecting mutations in the DLX3 gene using next-generation sequencing, aiding in clinical management and genetic counseling.

How to Prepare

  • No fasting required
  • Bring detailed clinical history and family pedigree
  • Genetic counseling session recommended prior to testing

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This test is essential for confirming Trichodontoosseous syndrome diagnosis, guiding treatment, and family planning counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required
ContainerEDTA tube or FTA card
Collection MethodVenipuncture or FTA card collection

Sample Stability

Blood sample stable for 48 hours at room temperature
FTA card stable for long-term storage at room temperature
Sample Rejection Criteria:
  • Hemolyzed or clotted sample
  • Insufficient sample volume
  • Incorrect sample container

Understanding Your Results

Results indicate the presence or absence of mutations in the DLX3 gene associated with Trichodontoosseous syndrome.
📊

Mutation Detected

Diagnosis of Trichodontoosseous syndrome is likely; clinical correlation and genetic counseling are advised.

📊

No Mutation Detected

Unlikely to have Trichodontoosseous syndrome, but other genetic or clinical factors should be considered.

⚠️ When to Consult a Doctor:

If symptoms such as delayed teeth eruption, abnormal tooth shape, or coarse hair are present, or if there is a family history of Trichodontoosseous syndrome.

Limitations

  • ⚠May not detect all possible mutations in the DLX3 gene
  • ⚠Requires correlation with clinical findings
  • ⚠Genetic counseling recommended for interpretation

Risks & Considerations

  • ●Minimal risk from blood draw, such as bruising or infection
  • ●Psychological impact of genetic diagnosis

Interfering Factors

  • ●Contaminated sample
  • ●Degraded DNA
  • ●Improper sample storage

Compare With Similar Tests

TestDLX3 Gene Trichodontoosseous syndrome NGS Genetic Test
ComparisonDLX3 Gene Trichodontoosseous syndrome NGS Genetic Test

Frequently Asked Questions

What is Trichodontoosseous syndrome?
Trichodontoosseous syndrome is a rare genetic disorder that affects the teeth, bones, and hair, caused by mutations in the DLX3 gene.
What causes Trichodontoosseous syndrome?
It is caused by mutations in the DLX3 gene, which provides instructions for a protein involved in the development of teeth, bones, and hair.
What are the symptoms of Trichodontoosseous syndrome?
Common symptoms include delayed eruption of teeth, abnormal tooth shape and size, weak enamel, irregular spacing of teeth, thickened bones in the skull and jaw, short stature, and coarse hair.
How is Trichodontoosseous syndrome diagnosed?
Diagnosis is typically through a genetic test, such as the DLX3 Gene NGS Genetic Test, which identifies mutations in the DLX3 gene.
What is the DLX3 Gene NGS Genetic Test?
It is a next-generation sequencing test that analyzes the DLX3 gene for mutations associated with Trichodontoosseous syndrome.
How much does the DLX3 Gene Test cost in India?
The cost is approximately INR 20000, which may vary by laboratory and location.
Is home sample collection available for this test?
Yes, free home sample collection is available for online bookings across many cities in India.
How long does it take to get the test results?
Results are typically delivered within 3 to 4 weeks after sample collection.
What sample is required for the test?
The test requires blood, extracted DNA, or one drop of blood on an FTA card.
Is fasting required before the test?
No, fasting is not required for this genetic test.
Can this test be done for children?
Yes, the test can be performed on individuals of all ages, including children, based on clinical indications.
What should I do if the test result is positive?
If a mutation is detected, consult a genetic counselor or healthcare provider for further evaluation, management, and family planning advice.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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