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DNMT1 Gene Neuropathy sensor type 1E NGS Genetic Test

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DNMT1 Gene Neuropathy sensor type 1E NGS Genetic Test

Short Name: DNMT1 Neuropathy Type 1E NGS

Also known as: Hereditary Sensory Neuropathy Type 1E NGS Test, DNMT1 Gene Sequencing, DNMT1 Neuropathy Type 1E Genetic Test

DNMT1 Gene Neuropathy sensor type 1E NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in Reports are typically issued 3 to 4 weeks after the sample reaches the laboratory.. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To detect disease-causing variants in the DNMT1 gene in a person with suspected hereditary sensory neuropathy type 1E, confirm a clinical diagnosis, identify family members at risk, and support genetic counseling and family planning decisions.

Test Code
4430
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
Reports are typically issued 3 to 4 weeks after the sample reaches the laboratory.
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

A genetic counseling session is required before sample collection. The counselor will document clinical history and family pedigree. No fasting is required. Inform the laboratory about any blood transfusion or bone marrow transplant in the past 3 months.

Method: Peripheral venipuncture or dried blood spot

Step 2

Laboratory Analysis

A blood sample is collected from a vein in the arm, or a dried blood spot is placed on an FTA card. The sample is labelled and transported to the laboratory for NGS analysis.

Step 3

Report Delivery

You can resume normal activities immediately. The laboratory will process the sample and release the final report in 3 to 4 weeks.

Timeline: Reports are typically issued 3 to 4 weeks after the sample reaches the laboratory.

Patient Instructions

1
Before the Test:A genetic counseling session is required before sample collection. The counselor will document the clinical history and family pedigree. No fasting is required, and no change in routine medications is needed.
2
During the Test:A small blood sample is collected from a vein in the arm, or a blood spot is placed on an FTA card. The sample is sealed, labelled, and sent to the laboratory for NGS analysis.
3
After the Test:You can return to normal daily activities immediately. The laboratory will process the sample and release the final report within 3 to 4 weeks.

About This Test

Who Should Get This Test

To detect disease-causing variants in the DNMT1 gene in a person with suspected hereditary sensory neuropathy type 1E, confirm a clinical diagnosis, identify family members at risk, and support genetic counseling and family planning decisions.

How to Prepare

  • No fasting required
  • Genetic counseling session and signed consent are mandatory
  • Provide clinical details and family pedigree chart during counseling
  • Bring your prescription or clinician referral if available

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"The neurologist will correlate the genetic test result with clinical signs, nerve conduction studies, and imaging as needed. Genetic confirmation supports early intervention, surveillance, and family screening. For reproductive planning, a separate genetic counseling session is recommended to review recurrence risk and options."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 mL whole blood / extracted DNA / one drop blood on FTA card
ContainerEDTA vacutainer or FTA card
Collection MethodPeripheral venipuncture or dried blood spot

Sample Stability

Blood sample: stable for 24 to 48 hours at 2 to 8 degree Celsius
Extracted DNA: stable at -20 degree Celsius for long-term storage
FTA card blood spot: stable for several weeks at ambient temperature
Sample Rejection Criteria:
  • Mislabeled sample
  • Sample received without genetic counseling or consent
  • Hemolysed, clotted, or damaged blood sample
  • Insufficient blood, DNA, or FTA card sample quantity

Understanding Your Results

The molecular test report should be interpreted by a clinical geneticist in the context of the patient's clinical presentation, family history, and other relevant neurological investigations.
Pathogenic or likely pathogenic variant detected: indicates molecular confirmation of DNMT1 gene neuropathy sensor type 1E and supports a genetic risk discussion.
Variant of uncertain significance detected: current evidence is insufficient to classify the variant as disease-causing; additional family testing or further evaluation may be recommended.
No pathogenic variant detected: no reportable DNMT1 mutation was identified; this does not exclude all hereditary neuropathies, and a broader NGS panel may be considered.
Benign or likely benign variant detected: not considered related to the disease process.
⚠️ When to Consult a Doctor:

Consult a neurologist if you have persistent tingling, numbness, muscle weakness, or walking difficulty. A clinical geneticist may also be consulted if hereditary neuropathy is suspected or if you need reproductive risk assessment.

Limitations

  • ⚠This test is specific to the DNMT1 gene and may not identify mutations in other genes causing neuropathy.
  • ⚠Large deletions, duplications, or deep intronic variants may not be detected by routine NGS.
  • ⚠A negative result does not exclude all hereditary or non-genetic causes of neuropathy.
  • ⚠Variants of uncertain significance may be reported; further family studies may be required.
  • ⚠Genetic testing cannot precisely predict symptom onset, severity, or disease progression in every individual.

Risks & Considerations

  • ●Minimal risk of bruising or bleeding at the venipuncture site
  • ●Mild discomfort during blood collection
  • ●No significant physical risk from dried blood spot collection on FTA card

Interfering Factors

  • ●Gross hemolysis or clot in the blood sample may affect DNA extraction quality.
  • ●Inadequate DNA quantity or degraded DNA can lead to inconclusive results.
  • ●Sample contamination during collection or handling may affect sequencing.
  • ●Prior bone marrow transplantation may alter blood-based genetic test results.
  • ●Large gene deletions or duplications may not be detected by standard NGS sequencing alone.

Compare With Similar Tests

TestDNMT1 Gene Neuropathy sensor type 1E NGS Genetic TestFocused DNMT1 gene NGS testHereditary neuropathy NGS panelSanger sequencing for known familial variant
ComparisonDNMT1 Gene Neuropathy sensor type 1E NGS Genetic Test

Frequently Asked Questions

What is DNMT1 gene neuropathy sensor type 1E?
DNMT1 gene neuropathy sensor type 1E is a rare hereditary sensory neuropathy caused by mutations in the DNMT1 gene. The gene normally helps regulate gene expression through an enzyme, and mutations can lead to progressive nerve damage.
What are the common symptoms of this condition?
Common symptoms include tingling or numbness in the hands and feet, muscle weakness, difficulty walking, and reduced sensation in the hands and feet. Symptoms may worsen over time.
What is NGS genetic testing?
NGS, or next-generation sequencing, is a high-throughput DNA sequencing method that can analyse multiple genes at the same time. It is accurate and efficient for detecting mutations in genes such as DNMT1.
How is this test performed?
A blood sample, extracted DNA sample, or one drop of blood on an FTA card is collected. The sample is sent to the laboratory, where the DNMT1 gene is analysed using NGS technology.
Do I need to fast before this genetic test?
No, fasting is not required for the DNMT1 Gene Neuropathy Sensor Type 1E NGS Genetic Test.
How long does it take to get the report?
The report is usually available in 3 to 4 weeks after the sample is received by the laboratory.
What is the price of this test?
The test costs Rs 20000. DNA Labs India offers free home sample collection for online bookings.
Is this test covered by insurance?
Insurance coverage depends on your specific health insurance policy and corporate scheme. It is recommended to check directly with your insurance provider.
Can this test be used for family planning?
Yes, the test result can help assess the risk of passing the mutation to children and can support reproductive planning decisions when interpreted with genetic counseling.
What does a negative result mean?
A negative result means no pathogenic DNMT1 mutation was detected in the analysed gene. It does not completely exclude other hereditary or non-genetic causes of neuropathy.
Why is genetic counseling recommended?
Genetic counseling helps explain the inheritance pattern, family risk, clinical implications, and reproductive options before and after testing.
Can this test detect all types of neuropathy?
No, this test is specific to DNMT1 gene neuropathy sensor type 1E. Other genetic or non-genetic causes of neuropathy may require a broader neuropathy panel or additional clinical evaluation.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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