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DOCK6 Gene Adams-Oliver syndrome type 2 NGS Genetic Test

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DOCK6 Gene Adams-Oliver syndrome type 2 NGS Genetic Test

Short Name: DOCK6 AOS Type 2 NGS Test

Also known as: Adams-Oliver Syndrome Type 2, AOS Type 2, DOCK6-related AOS

DOCK6 Gene Adams-Oliver syndrome type 2 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To detect mutations in the DOCK6 gene for definitive diagnosis of Adams-Oliver Syndrome Type 2, aiding in clinical management, carrier identification, and genetic counseling.

Test Code
4813
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

Clinical history of the patient and a genetic counseling session to draw a pedigree chart of affected family members are required.

Method: Venipuncture

Step 2

Laboratory Analysis

Blood sample collection via venipuncture or use of FTA card for one drop of blood.

Step 3

Report Delivery

Sample is transported to the laboratory under ambient conditions for NGS analysis.

Timeline: 3 to 4 weeks

Patient Instructions

1
Before the Test:Genetic counseling session and clinical evaluation to assess symptoms and family history.
2
During the Test:Blood sample collection is performed, which is a minimally invasive procedure.
3
After the Test:Wait for the report (3-4 weeks) and follow up with a genetic counselor for result interpretation and next steps.

About This Test

Who Should Get This Test

To detect mutations in the DOCK6 gene for definitive diagnosis of Adams-Oliver Syndrome Type 2, aiding in clinical management, carrier identification, and genetic counseling.

How to Prepare

  • Ensure proper identification and prescription
  • No fasting required
  • Collect sample in appropriate container (EDTA tube or FTA card)

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This test is essential for confirming Adams-Oliver Syndrome Type 2, guiding management, and informing family planning decisions."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample VolumeAs required
ContainerEDTA tube or FTA card
Collection MethodVenipuncture

Sample Stability

Blood sample stable at room temperature for 24 hours
Extracted DNA stable at -20°C for long-term storage
Sample Rejection Criteria:
  • Hemolyzed or clotted sample
  • Insufficient sample volume
  • Improper labeling or container

Understanding Your Results

Results indicate the presence or absence of pathogenic mutations in the DOCK6 gene, which is associated with Adams-Oliver Syndrome Type 2.
📊

Positive

Pathogenic variant detected in the DOCK6 gene, confirming diagnosis of AOS Type 2. Genetic counseling recommended.

📊

Negative

No pathogenic variants detected. Clinical correlation is advised, as other genetic or non-genetic causes may be present.

📊

Variant of uncertain significance

A genetic variant was found, but its clinical significance is unclear. Further testing and family studies may be needed.

⚠️ When to Consult a Doctor:

If symptoms of Adams-Oliver Syndrome are present, such as scalp defects, limb anomalies, or heart issues, or for family planning if there is a known family history.

Limitations

  • ⚠May not detect all possible mutations in the DOCK6 gene
  • ⚠Requires genetic counseling for accurate interpretation
  • ⚠Results should be correlated with clinical findings

Risks & Considerations

  • ●Minimal risk from blood draw (e.g., bruising, infection)
  • ●Psychological impact of genetic results
  • ●Potential for uncertain results requiring further testing

Interfering Factors

  • ●Sample contamination
  • ●Degraded DNA
  • ●Hemolyzed blood sample

Compare With Similar Tests

TestDOCK6 Gene Adams-Oliver syndrome type 2 NGS Genetic TestSanger Sequencing for DOCK6Whole Exome SequencingChromosomal MicroarrayCardiac Echocardiogram
ComparisonDOCK6 Gene Adams-Oliver syndrome type 2 NGS Genetic Test

Frequently Asked Questions

What is Adams-Oliver Syndrome Type 2?
Adams-Oliver Syndrome Type 2 is a rare genetic disorder caused by mutations in the DOCK6 gene, characterized by scalp defects, limb anomalies, and cardiovascular malformations.
What causes AOS Type 2?
AOS Type 2 is caused by mutations in the DOCK6 gene, which is involved in the development of the cardiovascular and nervous systems.
What are the symptoms of AOS Type 2?
Symptoms include scalp defects (e.g., hairless patches), limb anomalies (e.g., missing fingers), heart defects, intellectual disability, seizures, and eye abnormalities.
How is AOS Type 2 diagnosed?
Diagnosis involves clinical examination, echocardiogram for heart issues, and genetic testing to confirm mutations in the DOCK6 gene.
What is the DOCK6 gene?
The DOCK6 gene provides instructions for making a protein important for cell signaling and development, and mutations can lead to Adams-Oliver Syndrome.
What is NGS Genetic Testing?
Next-generation sequencing (NGS) is a technology that analyzes multiple genes simultaneously with high accuracy, used here to detect DOCK6 gene mutations.
How accurate is the NGS test for AOS Type 2?
The NGS test has high accuracy for detecting mutations in the DOCK6 gene, providing a definitive diagnosis when combined with clinical evaluation.
What is the cost of the test in India?
The cost of the DOCK6 Gene Adams-Oliver Syndrome Type 2 NGS Genetic Test is approximately INR 20,000 at DNA Labs India.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across many cities in India.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
Is genetic counseling provided?
Yes, a genetic counseling session is required before testing to draw a pedigree chart and discuss implications.
What should I do if the test is positive?
If positive, consult with a genetic counselor or healthcare provider for management options, family planning, and potential interventions.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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