DPY19L2 Gene SPGF9 NGS Genetic Test
Also known as: SPGF9 Test, DPY19L2 Mutation Test, Globozoospermia Genetic Test
DPY19L2 Gene SPGF9 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SULOCHANA HEMCHANDRA HOLLA
Consultant Medical Geneticist · Reg: 8532
Last reviewed: September 7, 2026
Overview
The purpose of the DPY19L2 Gene SPGF9 NGS Genetic Test is to diagnose globozoospermia and identify genetic mutations in the DPY19L2 gene that cause male infertility. It aids in clinical decision-making, genetic counseling, and personalized treatment planning for affected individuals.
- Test Code
- 5555
- Price
- ₹20,000
- Sample Type
- Blood or Extracted DNA or One drop Blood on FTA Card
- Result Time
- 3 to 4 Weeks
- Fasting Required
- No
- Method
- NGS Technology
Sample Collection
No specific preparation is required. Ensure genetic counseling is completed and clinical history is provided.
Method: Venipuncture or FTA card collection
Laboratory Analysis
A blood sample will be drawn via venipuncture or a drop of blood collected on an FTA card by a trained phlebotomist.
Report Delivery
Apply pressure to the puncture site to prevent bleeding. Store the sample as instructed and transport to the laboratory promptly.
Timeline: 3 to 4 Weeks
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the DPY19L2 Gene SPGF9 NGS Genetic Test is to diagnose globozoospermia and identify genetic mutations in the DPY19L2 gene that cause male infertility. It aids in clinical decision-making, genetic counseling, and personalized treatment planning for affected individuals.
How to Prepare
- Fast for 8-12 hours if specified, though not typically required.
- Avoid strenuous activity before sample collection.
- Bring identification and test requisition form.
- Inform the collector of any medications or health conditions.
Doctor's Notes
Reviewed by Dr SULOCHANA HEMCHANDRA HOLLA — MBBS, MD (Medical Genetics) · Reg. No. 8532
"This test is crucial for diagnosing genetic causes of male infertility, such as globozoospermia, and guiding personalized treatment options."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Hemolyzed or clotted blood samples
- Insufficient sample volume
- Incorrect labeling or missing documentation
- Contaminated or degraded DNA samples
Understanding Your Results
Positive for pathogenic variant
Confirms diagnosis of globozoospermia due to DPY19L2 mutation. Genetic counseling and assisted reproductive options recommended.
Negative for pathogenic variant
No mutations detected in DPY19L2 gene. Consider other genetic or non-genetic causes of infertility.
Variant of uncertain significance (VUS)
Further testing or family studies may be needed for clinical correlation.
Consult a doctor if you experience persistent infertility, abnormal semen analysis results, or have a family history of genetic disorders. Discuss test results with a genetic specialist for personalized advice.
Limitations
- ⚠May not detect all rare variants or epigenetic changes
- ⚠Results require interpretation by a genetic specialist
- ⚠Does not assess other causes of male infertility beyond DPY19L2 mutations
- ⚠Turnaround time of 3-4 weeks may delay clinical decisions
Risks & Considerations
- ●Minor bruising or discomfort at the blood draw site
- ●Rare risk of infection
- ●No significant risks associated with genetic testing itself
Interfering Factors
- ●Sample contamination
- ●Degraded DNA quality
- ●Incorrect sample collection or storage
- ●Technical errors in NGS sequencing
Compare With Similar Tests
| Test | DPY19L2 Gene SPGF9 NGS Genetic Test | Y Chromosome Microdeletion Test | Karyotyping | Semen Analysis | Hormone Level Tests |
|---|---|---|---|---|---|
| Comparison | DPY19L2 Gene SPGF9 NGS Genetic Test | Focuses on Y chromosome deletions; DPY19L2 test specifically targets gene mutations. | Analyzes chromosome structure; DPY19L2 test uses NGS for detailed gene sequencing. | Assesses sperm count and morphology; DPY19L2 test identifies genetic causes. | Evaluates hormonal imbalances; DPY19L2 test is genetic-based. |
Frequently Asked Questions
What is the DPY19L2 gene?
What is globozoospermia?
How is the SPGF9 NGS Genetic Test performed?
What is the cost of the DPY19L2 Gene SPGF9 NGS Genetic Test?
Is the test covered by insurance?
How long does it take to get results?
What are the symptoms of globozoospermia?
Can globozoospermia be treated?
Who should take this test?
What is NGS technology?
Is home sample collection available?
What do the results mean?
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We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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