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DSG1 Gene Keratosis palmoplantaris striata type 1 NGS Genetic Test

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DSG1 Gene Keratosis palmoplantaris striata type 1 NGS Genetic Test

Short Name: DSG1 Gene KPPS Type 1 NGS Test

Also known as: Striate Palmoplantar Keratoderma Type 1, KPPS Type 1

DSG1 Gene Keratosis palmoplantaris striata type 1 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses Next-Generation Sequencing (NGS) on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic TestAll Ages🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SHAILAJA RAGHUNATH MURDESHWAR

Dr SHAILAJA RAGHUNATH MURDESHWAR

Consultant Physician · Reg: 8052

Last reviewed: September 7, 2026

Overview

To diagnose Keratosis Palmoplantaris Striata Type 1 by identifying mutations in the DSG1 gene using next-generation sequencing.

Test Code
5044
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
Next-Generation Sequencing (NGS)
Step 1

Sample Collection

Genetic counseling session recommended. Provide clinical history and family pedigree.

Method: Venipuncture or Finger Prick

Step 2

Laboratory Analysis

Blood sample collected via venipuncture or finger prick.

Step 3

Report Delivery

Sample sent to lab for analysis. Report delivered in 3-4 weeks.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling and clinical history review.
2
During the Test:Sample collection and processing.
3
After the Test:Report generation and delivery.

About This Test

Who Should Get This Test

To diagnose Keratosis Palmoplantaris Striata Type 1 by identifying mutations in the DSG1 gene using next-generation sequencing.

How to Prepare

  • Avoid eating or drinking before blood collection if specified
  • Ensure proper labeling of sample
  • Use sterile equipment

Doctor's Notes

Reviewed by — MBBS, MD (General Medicine) · Reg. No. 8052

"Genetic testing is essential for accurate diagnosis and personalized management of hereditary skin disorders like KPPS Type 1."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 mL
ContainerEDTA Tube or FTA Card
Collection MethodVenipuncture or Finger Prick

Sample Stability

Room Temperature24 hours
Refrigerated7 days
Sample Rejection Criteria:
  • Hemolyzed sample
  • Insufficient sample volume
  • Incorrect sample type

Understanding Your Results

Results indicate the presence or absence of mutations in the DSG1 gene associated with KPPS Type 1.
📊

Mutation detected

Confirms diagnosis of KPPS Type 1. Genetic counseling and management recommended.

📊

No mutation detected

KPPS Type 1 unlikely. Consider other diagnoses or further testing.

⚠️ When to Consult a Doctor:

If symptoms persist or worsen, or if genetic test results are positive, consult a dermatologist or geneticist for management.

Limitations

  • ⚠May not detect all types of mutations
  • ⚠Results require genetic counseling
  • ⚠Not a substitute for clinical diagnosis

Risks & Considerations

  • ●Minimal risk from blood draw
  • ●Potential for inconclusive results

Interfering Factors

  • ●Contaminated DNA sample
  • ●Improper sample collection
  • ●Technical errors in sequencing

Compare With Similar Tests

TestDSG1 Gene Keratosis palmoplantaris striata type 1 NGS Genetic TestOther Palmoplantar Keratoderma Tests
ComparisonDSG1 Gene Keratosis palmoplantaris striata type 1 NGS Genetic Test

Frequently Asked Questions

What is the DSG1 Gene KPPS Type 1 NGS Genetic Test?
It is a genetic test that uses next-generation sequencing to identify mutations in the DSG1 gene, which causes Keratosis Palmoplantaris Striata Type 1.
How is the test performed?
A blood sample is collected and analyzed using NGS technology to detect mutations in the DSG1 gene.
What is the cost of the test?
The test costs INR 20,000 in India, with home sample collection available.
Is home sample collection available?
Yes, DNA Labs India offers free home sample collection for this test across India.
How long does it take to get results?
Results are typically available within 3 to 4 weeks after sample collection.
What are the symptoms of KPPS Type 1?
Symptoms include thick, scaly skin on palms and soles, thickened skin on fingers and toes, and cracked or bleeding skin.
How is KPPS Type 1 diagnosed?
Diagnosis is based on physical examination, family history, and genetic testing to confirm DSG1 gene mutations.
Is genetic testing necessary for diagnosis?
Yes, genetic testing is essential for accurate diagnosis and to rule out other conditions.
What does a positive result mean?
A positive result confirms the presence of a DSG1 gene mutation, indicating KPPS Type 1.
What does a negative result mean?
A negative result means no mutation was detected, making KPPS Type 1 unlikely.
Are there any risks associated with the test?
The test involves minimal risks from blood draw, such as bruising or infection, but these are rare.
How can I prepare for the test?
No special preparation is needed, but genetic counseling is recommended before testing.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

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✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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