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DSG4 Gene Hypotrichosis type 6 NGS Genetic Test

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DSG4 Gene Hypotrichosis type 6 NGS Genetic Test

Short Name: DSG4 Hypotrichosis Type 6 NGS Test

Also known as: Hypotrichosis type 6, DSG4-related hair loss

DSG4 Gene Hypotrichosis type 6 NGS Genetic Test test available at DNA Labs India for ₹20,000. Uses NGS Technology on Blood or Extracted DNA or One drop Blood on FTA Card samples. Results in 3 to 4 Weeks. Free home collection in 300+ cities across India.

NGS Genetic Test🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

The purpose of this test is to identify mutations in the DSG4 gene to diagnose Hypotrichosis Type 6, guide treatment decisions, and facilitate genetic counseling for affected individuals and families.

Test Code
4985
Price
₹20,000
Sample Type
Blood or Extracted DNA or One drop Blood on FTA Card
Result Time
3 to 4 Weeks
Fasting Required
No
Method
NGS Technology
Step 1

Sample Collection

No specific preparation required. Provide clinical history and family pedigree during genetic counseling.

Method: Venipuncture

Step 2

Laboratory Analysis

Blood sample collected via venipuncture by a trained phlebotomist. For FTA card, a single drop of blood is applied.

Step 3

Report Delivery

Apply pressure to the puncture site to prevent bruising. Store sample as per instructions for stability.

Timeline: 3 to 4 Weeks

Patient Instructions

1
Before the Test:Genetic counseling session to discuss symptoms, family history, and test implications.
2
During the Test:Blood sample collection; procedure is quick and minimally invasive.
3
After the Test:Results delivered in 3-4 weeks; follow-up with genetic counselor for interpretation.

About This Test

Who Should Get This Test

The purpose of this test is to identify mutations in the DSG4 gene to diagnose Hypotrichosis Type 6, guide treatment decisions, and facilitate genetic counseling for affected individuals and families.

How to Prepare

  • Ensure patient identification is accurate
  • Use sterile equipment for blood collection
  • Label samples correctly with patient details
  • Transport samples at ambient temperature unless specified

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"This test is essential for diagnosing hereditary hypotrichosis, guiding treatment, and informing family planning through genetic counseling."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeBlood or Extracted DNA or One drop Blood on FTA Card
Sample Volume5 ml blood
ContainerEDTA tube or FTA Card
Collection MethodVenipuncture

Sample Stability

Blood sample stable for 48 hours at room temperature
Extracted DNA stable for longer periods if stored properly
Sample Rejection Criteria:
  • Hemolyzed or clotted blood sample
  • Insufficient sample volume
  • Incorrect labeling or missing patient information

Understanding Your Results

Results indicate the presence or absence of pathogenic variants in the DSG4 gene. Positive results confirm diagnosis, while negative results may require further testing.
📊

Positive for pathogenic variant

Confirms diagnosis of DSG4 Gene Hypotrichosis Type 6. Genetic counseling recommended.

📊

Negative for pathogenic variant

No mutations detected in the DSG4 gene. Consider other genetic or non-genetic causes.

📊

Variant of uncertain significance

Further testing or family studies may be needed for clarification.

⚠️ When to Consult a Doctor:

Consult a geneticist or dermatologist if symptoms of hair loss or skin irritation persist, or for family planning guidance after a positive test result.

Limitations

  • ⚠May not detect all possible mutations in the DSG4 gene
  • ⚠Requires interpretation by a genetic counselor or specialist
  • ⚠Results may take several weeks due to complex analysis

Risks & Considerations

  • ●Minor bruising at puncture site
  • ●Rare risk of infection
  • ●Emotional impact of genetic results

Interfering Factors

  • ●Contaminated or degraded DNA sample
  • ●Hemolyzed blood sample
  • ●Improper sample storage or handling

Compare With Similar Tests

TestDSG4 Gene Hypotrichosis type 6 NGS Genetic TestComprehensive Hair Loss PanelSanger Sequencing for DSG4Skin BiopsyWhole Exome Sequencing
ComparisonDSG4 Gene Hypotrichosis type 6 NGS Genetic Test

Frequently Asked Questions

What is DSG4 Gene Hypotrichosis Type 6?
It is a rare genetic disorder caused by mutations in the DSG4 gene, leading to hair loss starting in infancy.
How is the test performed?
The test uses next-generation sequencing (NGS) to analyze the DSG4 gene from a blood or DNA sample.
What is the cost of the test?
The test costs INR 20,000 at DNA Labs India, with home collection available.
How long does it take to get results?
Results are typically available in 3 to 4 weeks after sample collection.
Is home sample collection available?
Yes, free home collection is offered for online bookings across India.
What are the symptoms of this condition?
Symptoms include sparse, thin, brittle hair, and sometimes skin irritation around hair follicles.
Who should get this test?
Individuals with unexplained hair loss from infancy, or those with a family history of hypotrichosis.
Is the test covered by insurance?
Coverage varies; check with your insurance provider. DNA Labs India offers competitive pricing.
What is the accuracy of the test?
NGS technology provides high accuracy for detecting pathogenic variants in the DSG4 gene.
Can this test be done on children?
Yes, the test can be performed on individuals of all ages, including infants.
What if the test is positive?
A positive result confirms the diagnosis, and genetic counseling will guide management and family planning.
How do I prepare for the test?
No special preparation is needed; provide clinical history during genetic counseling before sample collection.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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For Hospitals & Clinics

Reference Laboratory Services

We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.

LIMS Integration

Your Data Privacy

Your medical data is protected under Indian law.

✓ Stored in India: All patient records are stored on servers located in India. No data is transferred outside the country.

✓ DPDP Act Compliant: Under the Digital Personal Data Protection Act 2023, you can request deletion of your records at any time by contacting support.

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