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FISH - Amnio One Probe: Trisomy 21 / Down Syndrome Test

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FISH - Amnio One Probe: Trisomy 21 / Down Syndrome Test

Short Name: FISH Trisomy 21 Test

Also known as: Trisomy 21 FISH Test, Amniocentesis FISH Probe

FISH - Amnio One Probe: Trisomy 21 / Down Syndrome Test test available at DNA Labs India for ₹4,500. Uses Fluorescence In Situ Hybridization (FISH) on Amniotic fluid samples. Results in Results are typically available within 4 days after sample collection.. Free home collection in 300+ cities across India.

DiagnosticFemalePrenatal🏠 Home Collection

✍️ Written By

🩺 Medically Reviewed By

Dr SULOCHANA HEMCHANDRA HOLLA

Dr SULOCHANA HEMCHANDRA HOLLA

Consultant Medical Geneticist · Reg: 8532

Last reviewed: September 7, 2026

Overview

To detect Trisomy 21 (Down Syndrome) in the fetus through prenatal screening, aiding in early diagnosis and management.

Test Code
570
Price
₹4,500
Sample Type
Amniotic fluid
Result Time
Results are typically available within 4 days after sample collection.
Fasting Required
No
Method
Fluorescence In Situ Hybridization (FISH)
Step 1

Sample Collection

Ensure gestation age is over 15 weeks. Complete and sign the required consent and requisition forms.

Method: Amniocentesis

Step 2

Laboratory Analysis

Amniocentesis procedure performed by a trained healthcare provider. Local anesthesia may be used.

Step 3

Report Delivery

Rest for a short period. Monitor for any signs of complications such as cramping or leakage.

Timeline: Results are typically available within 4 days after sample collection.

Patient Instructions

1
Before the Test:Consult your doctor to discuss the procedure, risks, and benefits. Ensure all forms are signed.
2
During the Test:The amniocentesis procedure takes about 30 minutes. You may feel slight discomfort.
3
After the Test:Avoid strenuous activity for 24 hours. Report any severe pain, fever, or fluid leakage to your doctor.

About This Test

Who Should Get This Test

To detect Trisomy 21 (Down Syndrome) in the fetus through prenatal screening, aiding in early diagnosis and management.

How to Prepare

  • Sample must be taken after 15 weeks of gestation.
  • Duly filled Prenatal Genetic Testing Consent Form (Form 18) is mandatory.
  • Chromosome & FISH analysis Requisition Form (Form 17) must be submitted.
  • Collect 10 mL of amniotic fluid in a sterile screw capped container.
  • Ship at 18-22°C. Do not freeze.

Doctor's Notes

Reviewed by — MBBS, MD (Medical Genetics) · Reg. No. 8532

"Early detection of Trisomy 21 through FISH testing allows for informed decision-making and early intervention, improving outcomes for the child."

Last medically reviewed: September 7, 2026

Test Parameters & Specifications

Sample TypeAmniotic fluid
Sample Volume10 mL (7 mL min.)
ContainerSterile screw capped container
Collection MethodAmniocentesis

Sample Stability

Room Temperature: 48 hours
Refrigerator: Not Applicable
Frozen: Not Applicable
Sample Rejection Criteria:
  • Sample in incorrect container
  • Sample volume less than 7 mL
  • Sample not stored at recommended temperature
  • Missing or incomplete forms

Understanding Your Results

Results indicate the presence or absence of an extra chromosome 21 in fetal cells.
Positive for Trisomy 21: Three copies of chromosome 21 detected, indicating Down Syndrome.
Negative for Trisomy 21: Two copies of chromosome 21 detected, normal result.
Inconclusive: Insufficient cells or technical issues; repeat test may be needed.
⚠️ When to Consult a Doctor:

If results are positive or if there are any concerns about the test procedure or fetal health, consult your gynecologist or genetic counselor immediately.

Limitations

  • ⚠Detects only Trisomy 21; does not screen for other chromosomal abnormalities
  • ⚠Requires confirmation with full chromosome analysis
  • ⚠Risk of false positive or false negative results
  • ⚠Invasive procedure with associated risks

Risks & Considerations

  • ●Risk of miscarriage (about 0.1-0.3%)
  • ●Infection at the puncture site
  • ●Bleeding or cramping
  • ●Leakage of amniotic fluid

Interfering Factors

  • ●Contaminated or insufficient amniotic fluid sample
  • ●Improper storage or transportation of sample
  • ●Maternal cell contamination

Compare With Similar Tests

TestFISH - Amnio One Probe: Trisomy 21 / Down Syndrome TestNIPT (Non-Invasive Prenatal Testing)Amniocentesis KaryotypeChorionic Villus Sampling (CVS)Ultrasound
ComparisonFISH - Amnio One Probe: Trisomy 21 / Down Syndrome Test

Frequently Asked Questions

What is the FISH - Amnio One Probe: Trisomy 21 / Down Syndrome Test?
It is a prenatal diagnostic test that uses Fluorescence In Situ Hybridization (FISH) to detect Trisomy 21 in fetal cells from amniotic fluid.
How is the test performed?
A sample of amniotic fluid is collected via amniocentesis after 15 weeks of gestation. The fluid is then analyzed in the lab using FISH technology.
What is the cost of this test in India?
The test costs INR 4500 at DNA Labs India, with free home sample collection available.
Is the test safe?
The test involves amniocentesis, which has a small risk of miscarriage (about 0.1-0.3%). It is performed by experienced professionals to minimize risks.
When can I undergo this test?
The test is recommended after 15 weeks of gestation. Consult your doctor for the best timing.
How accurate is the FISH test for Down Syndrome?
FISH is highly accurate for detecting Trisomy 21, but it is often used in conjunction with full chromosome analysis for confirmation.
What are the risks associated with amniocentesis?
Risks include miscarriage, infection, bleeding, and cramping. These are rare when performed by skilled practitioners.
How long does it take to receive results?
Results are typically available within 4 days after sample collection.
Can this test detect other chromosomal issues?
This specific FISH probe is designed for Trisomy 21. For broader screening, other tests like full karyotype or NIPT are recommended.
Do I need to fast before the test?
No, fasting is not required for this test.
What documents are needed for the test?
You need to provide a duly filled Prenatal Genetic Testing Consent Form (Form 18) and Chromosome & FISH analysis Requisition Form (Form 17).
Is home sample collection available for this test?
Yes, DNA Labs India offers free home sample collection for online bookings across many cities in India.
Worried about the process? Our certified phlebotomists collect thousands of samples every month across India. The process takes under 5 minutes and is virtually painless. Questions? Message us on WhatsApp — we're here 7 days a week.

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