FISH - NSCLC (Non-Small Cell Lung Cancer) ALK1 & ROS1 Test
Short Name: FISH NSCLC ALK1 ROS1 Test
Also known as: ALK1 FISH Test, ROS1 FISH Test, NSCLC Genetic Panel, Fluorescence In Situ Hybridization for Lung Cancer
FISH - NSCLC (Non-Small Cell Lung Cancer) ALK1 & ROS1 Test test available at DNA Labs India for ₹16,000. Uses Fluorescence In Situ Hybridization (FISH) on Formalin fixed paraffin embedded tissue block samples. Results in Report available in 4 working days. Free home collection in 300+ cities across India.
🩺 Medically Reviewed By
Dr SHAILAJA RAGHUNATH MURDESHWAR
Consultant Physician · Reg: 8052
Last reviewed: September 7, 2026
Overview
The purpose of the FISH NSCLC ALK1 ROS1 test is to detect specific genetic rearrangements in the ALK1 and ROS1 genes within non-small cell lung cancer cells. Identifying these alterations is crucial for determining eligibility for targeted therapies, which can significantly enhance treatment efficacy and patient prognosis. This test supports personalized medicine by enabling oncologists to tailor treatment plans based on the genetic profile of the tumor.
- Test Code
- 586
- Price
- ₹16,000
- Sample Type
- Formalin fixed paraffin embedded tissue block
- Result Time
- Report available in 4 working days
- Fasting Required
- No
- Method
- Fluorescence In Situ Hybridization (FISH)
Sample Collection
Ensure the biopsy is performed by a qualified professional. Provide a duly filled Chromosome & FISH analysis Requisition Form (Form 17). No specific fasting or preparation is required for the patient.
Method: Biopsy collection
Laboratory Analysis
The biopsy procedure involves extracting tissue from the lung or suspected area. The sample must be handled carefully to maintain integrity for FISH analysis.
Report Delivery
The tissue block is preserved in formalin and embedded in paraffin for long-term stability. The sample is then shipped to the laboratory at room temperature.
Timeline: Report available in 4 working days
Patient Instructions
About This Test
Who Should Get This Test
The purpose of the FISH NSCLC ALK1 ROS1 test is to detect specific genetic rearrangements in the ALK1 and ROS1 genes within non-small cell lung cancer cells. Identifying these alterations is crucial for determining eligibility for targeted therapies, which can significantly enhance treatment efficacy and patient prognosis. This test supports personalized medicine by enabling oncologists to tailor treatment plans based on the genetic profile of the tumor.
How to Prepare
- Submit a formalin-fixed paraffin-embedded tissue block
- Ensure the block contains at least 10% tumor tissue
- Include a completed Chromosome & FISH analysis Requisition Form (Form 17)
- Ship the sample at room temperature to the laboratory
Doctor's Notes
Reviewed by Dr SHAILAJA RAGHUNATH MURDESHWAR — MBBS, MD (General Medicine) · Reg. No. 8052
"This FISH test is critical for identifying ALK1 and ROS1 rearrangements in NSCLC patients, enabling targeted therapies that significantly improve treatment outcomes and survival rates."
Last medically reviewed: September 7, 2026
Test Parameters & Specifications
Sample Stability
- Insufficient tumor content in the tissue block
- Missing or incomplete requisition form
- Improperly fixed or damaged sample
Understanding Your Results
Positive for ALK1 rearrangement
Indicates presence of ALK1 gene rearrangement; patient may be eligible for ALK-targeted therapies
Positive for ROS1 rearrangement
Indicates presence of ROS1 gene rearrangement; patient may be eligible for ROS1-targeted therapies
Negative for both rearrangements
No ALK1 or ROS1 rearrangements detected; consider alternative diagnostic or therapeutic approaches
Consult your oncologist if you experience persistent lung cancer symptoms such as cough, chest pain, or weight loss, or if you have been diagnosed with NSCLC and need genetic testing for treatment planning.
Limitations
- ⚠FISH may not detect all rare or novel rearrangements outside known variants
- ⚠Requires experienced personnel for accurate interpretation
- ⚠Limited to detecting rearrangements, not point mutations or other alterations
Risks & Considerations
- ●Risks associated with biopsy procedure, such as infection, bleeding, or pneumothorax
- ●Minimal laboratory-related risks during FISH analysis
Interfering Factors
- ●Poor tissue quality or insufficient tumor content
- ●Inadequate fixation or preservation of biopsy sample
- ●Technical errors in FISH probe application or interpretation
Compare With Similar Tests
| Test | FISH - NSCLC (Non-Small Cell Lung Cancer) ALK1 & ROS1 Test | PCR-based molecular tests | Next-generation sequencing (NGS) |
|---|---|---|---|
| Comparison | FISH - NSCLC (Non-Small Cell Lung Cancer) ALK1 & ROS1 Test |
Frequently Asked Questions
What is the FISH NSCLC ALK1 ROS1 test?
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Reference Laboratory Services
We serve as a reference laboratory for hospitals and clinics across India. Send samples from your facility with same-day pickup, priority processing, and results delivered through our online portal. Competitive institutional pricing available.
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